799766-13-5 | Heterocyclic Building Block-benzofuran

Simple exploration of 7-Bromo-4-methylbenzofuran

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C9H7BrO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 799766-13-5, in my other articles.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C9H7BrO, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 799766-13-5, Name is 7-Bromo-4-methylbenzofuran, molecular formula is C9H7BrO

The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N+-O- or CR3; Y is N, N+-O- or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3569O – PubChem

Analyzing the synthesis route of 799766-13-5

799766-13-5 7-Bromo-4-methylbenzofuran 21071800, abenzofuran compound, is more and more widely used in various fields.

799766-13-5, 7-Bromo-4-methylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,799766-13-5

A mixture of 4-methoxyphenylboronic acid (1.51 g, 9.95 mmol), Na2C03 (10.66 ml 2 N aqueous, 21.32 mmol), Pd (PPh3) 4 (0.411 g, 0.355 mmol), 7-bromo-4- methylbenzofuran (1.5 g, 7.11 mmol), and ethylene glycol dimethyl ether (75 ml) was heated to reflux overnight. The reaction was cooled, diluted with EtOAc and the layers separated. The organic layer was dried over anhydrous NA2S04, passed through a silica plug and concentrated. Column chromatography (10percent EtOAc/hexanes) afforded 1.59 g (94percent) product as a white waxy solid: mp 39-40 ¡ãC ; LH NMR (300 MHz, DMSO-d6) : 8 2. 51 (3H, s), 7.07 (2H, d, J = 8. 8 HZ), 7.08 (1H, d, J = 2. 3 HZ), 7.13 (1H, d, J = 7. 7 Hz), 7.37 (IH, d, J 7. 6HZ), 7.79 (2H, d, J = 8. 8 HZ), 8.04 (1H, d, J = 2. 2 HZ) ; MS (ESI) M/Z 239 ([M+H]+). Anal. for C16H1402 : Calc’d: C: 80. 65 H: 5.92 Found: C: 80. 89 H: 5.85

799766-13-5 7-Bromo-4-methylbenzofuran 21071800, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; WYETH; WO2004/103941; (2004); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 799766-13-5

As the paragraph descriping shows that 799766-13-5 is playing an increasingly important role.

799766-13-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.799766-13-5,7-Bromo-4-methylbenzofuran,as a common compound, the synthetic route is as follows.

To a solution of 7-bromo-4-methylbenzofuran (9.61 g) in THF (228 mL) at -78 ¡ãC was slowly added 2.5 M nBuLi in hexanes (21.9 mL, 54.6 mmol, 1.2 equiv). The resultant reaction mixture was stirred for 1 h, then quenched by the addition of water. The mixture was allowed to warm to RT extracted with EtOAc. The organic extracts were dried over Na2SO4 and evaporated. The oily residue was heated at 80 ¡ãC in the presence of CaH2, then distilled under vacuum at 110 ¡ãC to afford the product as a clear oil(4.51 g, 75percent). ?H NMR (500 MHz, CDC13) (57.64 (d, I = 2.2 Hz, 1H), 7.40 (d, I = 7.8 Hz, 1H), 7.22 (dd, I = 8.2, 7.3 Hz, 1H), 7.06 (m, 1H), 6.81 (d, I = 2.2 Hz, 1H), 2.54 (s, 3H).

As the paragraph descriping shows that 799766-13-5 is playing an increasingly important role.

Reference£º
Patent; FORUM PHARMCEUTICALS INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; MCRINER, Andrew, J.; (451 pag.)WO2016/201168; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem