799766-13-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.799766-13-5,7-Bromo-4-methylbenzofuran,as a common compound, the synthetic route is as follows.
To a solution of 7-bromo-4-methylbenzofuran (9.61 g) in THF (228 mL) at -78 ¡ãC was slowly added 2.5 M nBuLi in hexanes (21.9 mL, 54.6 mmol, 1.2 equiv). The resultant reaction mixture was stirred for 1 h, then quenched by the addition of water. The mixture was allowed to warm to RT extracted with EtOAc. The organic extracts were dried over Na2SO4 and evaporated. The oily residue was heated at 80 ¡ãC in the presence of CaH2, then distilled under vacuum at 110 ¡ãC to afford the product as a clear oil(4.51 g, 75percent). ?H NMR (500 MHz, CDC13) (57.64 (d, I = 2.2 Hz, 1H), 7.40 (d, I = 7.8 Hz, 1H), 7.22 (dd, I = 8.2, 7.3 Hz, 1H), 7.06 (m, 1H), 6.81 (d, I = 2.2 Hz, 1H), 2.54 (s, 3H).
As the paragraph descriping shows that 799766-13-5 is playing an increasingly important role.
Reference£º
Patent; FORUM PHARMCEUTICALS INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; MCRINER, Andrew, J.; (451 pag.)WO2016/201168; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem