With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57319-65-0,6-Aminoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.
57319-65-0, To a suspension of 6-aminoisobenzofuran-1(3H)-one 4 (13.43 g, 90 mmol) in CH2Cl2 (200 mL) at 0 C was added 2,2,2-trichloroethyl carbonochloridate (18.23 mL, 135 mmol) followed by pyridine (17.79 mL, 180 mmol) and allowed to stir at room temperature for 1 h. TLC and HPLC shows reaction was complete. Filtered and washed with DCM (2×30 ml) to afford product 5 as white solid (17.03g, 58%). LCMS: [M+1] = 324. 1H NMR (400 MHz,Acetone-D6): delta 9.55 (brs, 1H), 8.16 (d, J = 2.0 Hz, 1H), 7.91 (dd, J = 8.0, 2.0 Hz, 1H), 7.64 (d, J = 8.0 Hz, 1H), 5.36 (s, 2H), 4.95 (s, 2H).
The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chowdari, Naidu S.; Pan, Chin; Rao, Chetana; Langley, David R.; Sivaprakasam, Prasanna; Sufi, Bilal; Derwin, Daniel; Wang, Yichong; Kwok, Eilene; Passmore, David; Rangan, Vangipuram S.; Deshpande, Shrikant; Cardarelli, Pina; Vite, Gregory; Gangwar, Sanjeev; Bioorganic and Medicinal Chemistry Letters; vol. 29; 3; (2019); p. 466 – 470;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem