Heterocyclic Building Block-benzofuran

7169-34-8, Benzofuran-3(2H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7169-34-8, General procedure: In the following syntheses, coumaranone (1.00 mmol) and aldehyde (1.00 mmol) were combined in a microwave vial. 1 mL of the deep eutectic solvent formed from a 1:2 molar ratio of choline chloride and urea was added. The tube was then microwaved at 90 C for 30 minutes. At this point, the reaction was allowed to cool to room temperature and partitioned between water and methylene chloride. The organic layer was separated and concentrated to dryness in vacuo to afford the desired aurone. Further purification was performed as noted.

7169-34-8 Benzofuran-3(2H)-one 23556, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Taylor, Kimberly M.; Taylor, Zachary E.; Handy, Scott T.; Tetrahedron Letters; vol. 58; 3; (2017); p. 240 – 241;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95333-17-8,Benzofuran-4-carbonitrile,as a common compound, the synthetic route is as follows.

In a 100 mL single-necked flask, benzofuran-4-carbonitrile C1-1e (1.1 g, 7.68 mmol), BOC anhydride (2.5 g, 11.52 mmol), methanol (50 mL), and 10% palladium carbon (2 g, containing 50 %water). The reaction mixture was purged with hydrogen for 5 minutes, vented three times with a hydrogen balloon, and stirred at 60 C. for 18 hours under a hydrogen balloon. The mixture was filtered through celite, washed with methanol (50 mL X 2), and the filtrate was concentrated under reduced pressure.Compound C1-1f (1.5 g, 79% yield) was obtained., 95333-17-8

Big data shows that 95333-17-8 is playing an increasingly important role.

Reference£º
Patent; Shanghai Qingyu Pharmaceutical Technology Co., Ltd.; Zou Bin; Ma Shichao; Wang Xiang; Zhang Zhongguo; (92 pag.)CN110563722; (2019); A;,
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Benzofuran | C8H6O – PubChem

64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2-benzofuran-l(3H)-one To a microwave tube containing a stir bar was added 5-bromo-2-benzofuran-l (3H)-one (0.10 g, 0.47 mmol), Bis(pinacolato)diboron (0.12 g, 0.47 mmol), bis(diphenylphosphino)palladium(II) (0.010 g, 0.014 mmol), potassium acetate (0.14 g, 1.4 mmol) and anhydrous toluene (10 mL). The resulting mixture was capped and heated at 80 C for 2 h. The reaction mixture was diluted with benzene and washed successively with water and brine. The organic layer was then dried (Na2S04), filtered, and concentrated. The resulting residue was purified by silica gel column chromatography (hexanes/EtOAc = 1/1) to provide 5- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2-benzofuran-l(3H)-one. LC/MS: [(M+l)]+ =261.

64169-34-2, The synthetic route of 64169-34-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
Benzofuran – Wikipedia
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271-89-6, Benzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

POCl3 (4.73 mL, 50.79 mmol) was slowly added to a solution of DMF (6.56 mL, 84.75 mmol) while the temperature was maintained below 40 C. Then, benzofuran 1 (2.00 g,16.93 mol) was added dropwise to this reaction mixture below 40 C, over a period of 15 min. The mixture was heated at 80 C for 24 h. The reaction mixture was then poured into ice-water and carefully quenched with a solution of sodium hydroxide. The organic material was separated, and the aqueous layer was extracted with ethyl acetate. It was washed with brine and dried over anhydrous magnesium sulfate. The filtrate was concentrated, and was purified on silica gel column (petroleum ether: EtOAc = 10:1) to give product 2 (2.27 g, 90%) as brown oil. 1H NMR (400 MHz,CDCl3): delta 9.83 (1H, s, COH), 7.75-7.70 (1H, m, H-4), 7.56-7.54 (2H, m, H-6,7), 7.46 (1H, s, H-3), 7.32-7.28 (1H, m, H-5). 13C NMR (100 MHz, CDCl3): delta 179.63 (COH), 156.03 (C-7a), 152.52 (C-2), 129.07 (C-3a), 126.51 (C-6), 124.05 (C-5), 123.58 (C-4), 117.93 (C-3), 112.44 (C-7).

271-89-6, As the paragraph descriping shows that 271-89-6 is playing an increasingly important role.

Reference£º
Article; Shi, Yi-Min; Yang, Li-Juan; Chen, Wen; Sun, Cheng-Jun; Xu, Xiao-Liang; Zhou, Shu-Ya; Zhang, Hong-Bin; Yang, Xiao-Dong; Letters in drug design and discovery; vol. 11; 8; (2014); p. 975 – 984;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35700-40-4,2,3-Dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.

Method A To an ice-cooled solution of 2,3-dihydrobenzo[b]furan-7-carboxylic acid (15a) (0.33 g, 2.0 mmol) in 3 ml of TFA there was added dropwise 0.6 ml of HNO3. At the end of 1 hour, the cooling bath was removed. After an additional 3 hours of stirring, the mixture was poured into ice-water. The precipitate was collected on a filter to give 0.22 g (52.6%) of crude 15k. This was recrystallized from ethyl acetate to provide 88 mg of acid 15k (21.4%), mp 249-251.5C.

35700-40-4, As the paragraph descriping shows that 35700-40-4 is playing an increasingly important role.

Reference£º
Patent; Erbamont Inc.; EP234872; (1991); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13391-28-1,5-Methoxybenzofuran,as a common compound, the synthetic route is as follows.

Step 5: BBr3 (2.6 mL, 13.5 mmol) was added dropwise to S22-4 (2.0 g, 13.Smmol) in DCM (20mL) at -60 C under N2. The solution was stirred at 0C for 2h. The mixture was poured into iceand adjusted the pH to 1213. The inorganic phase was extracted with DCM. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, filtrated and concentrated to provide a residue, which was purified by column chromatography to afford S22-5.

13391-28-1, The synthetic route of 13391-28-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LIANG, Gui-Bai; ZHOU, Changyou; WANG, Haisheng; HUO, Xianghong; WO2015/95261; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206347-30-0,7-Bromo-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

[1289] A first intermediate compound 4-(2,3-Dihydro-benzofuran-7-yl)-piperazine-1-carboxylic acid tert-butyl ester, was produced as follows: A solution of bis-(dibenzylideneacetone)palladium(0) (4.92 g, 0.16 mol) and toluene (2500 ml) was degassed with nitrogen for 15 minutes. (Note: Degassing was continued during each addition. Time between additions was 15 minutes.) Then added was tri-o-tolylphosphine (4.92 g, 0.16 mol) then sodium t-butoxide (53.8 g, 0.56 mol) then Boc-piperazine (86.8 g, 0.47 mol) then a solution of 7-bromo-2,3-dihydro-benzofuran (79.6 g, 0.40 mol, prepared according to Tetrahedron Lett. 1998, 39, 2219) in toluene (100 ml). The reaction mixture was stirred at reflux for 16 h. By TLC, all starting material had been consumed. The cooled reaction mixture was filtered over a pad of Celite. The filtrate was concentrated under reduced pressure and the residue was triturated with ethyl acetate in heptane (50%). The insoluble material was filtered off and that filtrate was concentrated under reduced pressure. The crude residue was purified by flash column chromatography using ethyl acetate in heptane (50%) to give 46.4 g (38% yield) of the first intermediate compound as a tan solid., 206347-30-0

As the paragraph descriping shows that 206347-30-0 is playing an increasingly important role.

Reference£º
Patent; Clark, Jerry D.; Davis, Jamie M.; Favor, David; Fay, Lorraine K.; Franklin, Lloyd; Henegar, Kevin E.; Johnson, Douglas S.; Nichelson, Brian J.; Ou, Ligong; Repine, Joseph Thomas; Walters, Michael A.; White, Andrew David; Zhu, Zhijian; US2005/43309; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.,7169-34-8

General procedure: To a solution of benzofuran-3(2H)-one derivative (2a,b,d, 1.2 mmol) in ethanol (5 ml) in the presence of corresponding benzaldehyde (1.3 mmol), aqueous solution of 5% HCl (1 ml) was added and the mixture was refluxed for 6-9 hours (controlled by TLC). After cooling in an ice bath, the solution was neutralized by adding a cold solution of 2% KOH to reach the pH of 5-6. The resulting yellow precipitate was filtered and recrystallized from diluted methanol to give the desired products.

As the paragraph descriping shows that 7169-34-8 is playing an increasingly important role.

Reference£º
Article; Roshanzamir, Khashayar; Kashani-Amin, Elaheh; Ebrahim-Habibi, Azadeh; Navidpour, Latifeh; Letters in drug design and discovery; vol. 16; 3; (2019); p. 333 – 340;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57319-65-0, 6-Aminoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57319-65-0

Example 16 3-(6-Amino-3H-isobenzofuran-1-ylidene)-5-chloro-1,3-dihydro-indol-2-one To a solution of 5-chlorooxindole (0.629 g, 3.78 mmol) in 10.0 mL monoglyme was added 7.51 mL sodium hexamethyldisilazane (1.0 M in THF) over 3 min. After stirring at room temperature for 8 min, a slurry of 6-aminophthalide (0.561 g, 3.78 mmol) in 4.0 mL of monoglyme was added in one portion. The mixture was stirred for 40 min and then quenched into 100 mL of 4% aqueous HCl solution. The yellow solid was filtered and then partitioned between EtOAc and saturated NaHCO3 (heated to dissolve the solid). The organic phase was washed with H2O, brine and then dried with Na2SO4. The solvent was removed in vacuo and the residue was triturated with MeOH to give the title compound (439 mg, 39%) as a yellow solid.

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Allergan Sales, LLC; US6541504; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

52010-22-7, 4-Chlorophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,52010-22-7

(a) 3-bromo-4-chloroisobenzofuran-1(3H)-one (100) 4-chloroisobenzofuran-1(3H)-one (10 g, 59.32 mmol), (E)-2,2′-(diazene-1,2-diyl)bis(2-methylpropanenitrile) (0.974 g, 5.93 mmol) and 1-bromopyrrolidine-2,5-dione (11.61 g, 65.25 mmol) were dissolved CCl4 (100 mL) and heated at reflux for 2 hours. The reaction was cooled and filtered, the filtrate was evaporated to the desired compound as a yellow gum (14.20 g, 97% yield); 1H NMR (400.132 MHz, CDCl3) delta 7.32 (1H, s), 7.61 (1H, t), 7.73 (1H, d), 7.88 (1H, d); m/z (LC-MS, ESI+), RT=2.28 (M+H not detected).

52010-22-7 4-Chlorophthalide 3040300, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; MENEAR, Keith Allan; Javaid, Muhammad Hashim; Gomez, Sylvie; Hummersone, Marc Geoffrey; Lence, Carlos Fenandez; Martin, Niall Morrison Barr; Rudge, David Alan; Roberts, Craig Anthony; Blades, Kevin; US2009/192156; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem