271-89-6, Benzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
POCl3 (4.73 mL, 50.79 mmol) was slowly added to a solution of DMF (6.56 mL, 84.75 mmol) while the temperature was maintained below 40 C. Then, benzofuran 1 (2.00 g,16.93 mol) was added dropwise to this reaction mixture below 40 C, over a period of 15 min. The mixture was heated at 80 C for 24 h. The reaction mixture was then poured into ice-water and carefully quenched with a solution of sodium hydroxide. The organic material was separated, and the aqueous layer was extracted with ethyl acetate. It was washed with brine and dried over anhydrous magnesium sulfate. The filtrate was concentrated, and was purified on silica gel column (petroleum ether: EtOAc = 10:1) to give product 2 (2.27 g, 90%) as brown oil. 1H NMR (400 MHz,CDCl3): delta 9.83 (1H, s, COH), 7.75-7.70 (1H, m, H-4), 7.56-7.54 (2H, m, H-6,7), 7.46 (1H, s, H-3), 7.32-7.28 (1H, m, H-5). 13C NMR (100 MHz, CDCl3): delta 179.63 (COH), 156.03 (C-7a), 152.52 (C-2), 129.07 (C-3a), 126.51 (C-6), 124.05 (C-5), 123.58 (C-4), 117.93 (C-3), 112.44 (C-7).
271-89-6, As the paragraph descriping shows that 271-89-6 is playing an increasingly important role.
Reference£º
Article; Shi, Yi-Min; Yang, Li-Juan; Chen, Wen; Sun, Cheng-Jun; Xu, Xiao-Liang; Zhou, Shu-Ya; Zhang, Hong-Bin; Yang, Xiao-Dong; Letters in drug design and discovery; vol. 11; 8; (2014); p. 975 – 984;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem