Heterocyclic Building Block-benzofuran

Novel bis(benzothiazole-oxime)-based Pd(II)-complex: synthesis, characterization, quantum chemical calculations, and catalytic significance in Suzuki-Miyaura and Heck-Mizoroki cross coupling reactions was written by Darweesh, Ahmed F.;Mansour, Ahmed M.;Elwahy, Ahmed H. M.. And the article was included in Monatshefte fuer Chemie in 2016.Application of 38220-75-6 This article mentions the following:

In the present work, a novel binuclear benzothiazole-oxime Pd(II) complex was synthesized, characterized (elemental anal., IR spectroscopy, thermogravimetric anal., UV-visible spectroscopy, NMR, and conductance measurements), and explored for its catalytic activity in Suzuki-Miyaura and Heck-Mizoroki cross-coupling reactions of different aryl- and heteroaryl halides with arylboronic acids and styrene, resp., using the microwave irradiation conditions. The electronic arrangement, type of hybridization, and nature of bonding in the Pd-complex were investigated by natural bond orbital anal. Time-dependent d. functional theory calculations were carried out to understand the electronic transitions in the related exptl. observations. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application of 38220-75-6).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application of 38220-75-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Derivatization of tranexamic acid for its rapid spectrofluorimetric determination in pure form and pharmaceutical formulations: Application in human plasma was written by Omar, Mahmoud A.;Anwer, Ebtehal F.;Nour El-Deen, Deena A. M.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2021.Reference of 38183-12-9 This article mentions the following:

An ingenious approach for determination of tranexamic acid spectrofluorimetrically has been developed. This experiment is very simple, sensitive and selective method for determination of tranexamic acid in pure form, pharmaceutical dosage forms and in spiked human plasma. All optimal conditions needed in our proposed experiment have been determined and validated precisely. This developed method based on the reaction between the primary amino group found in the chem. structure of tranexamic acid with the fluorescamine reagent in presence of borate buffer (pH 8.3) that result in the formation of fluorescence product measured at 473.5 nm after excitation at 392 nm. We notice that the linearity of the resulted calibration curve found to be (0.1-0.9μg/mL) with LOD and LOQ results were 0.0237 and 0.0719 resp. The validation of the developed method is according to the international council for Harmonization (ICH) guidelines indicating good accuracy and precision. Finally, the developed method has been applied for in vitro study of tranexamic acid by making spiked human plasma with a mean percentage recovery 99.430 ± 0.623 as well as in its pharmaceutical dosage forms tablets and ampoules. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Reference of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Reference of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Multimodal Cleavable Reporters versus Conventional Labels for Optical Quantification of Accessible Amino and Carboxy Groups on Nano- and Microparticles was written by Moser, Marko;Nirmalananthan, Nithiya;Behnke, Thomas;Geissler, Daniel;Resch-Genger, Ute. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2018.Application of 38183-12-9 This article mentions the following:

Many applications of nanometer- and micrometer-sized particles include their surface functionalization with linkers, sensor mols., and analyte recognition moieties like (bio)ligands. This requires knowledge of the chem. nature and number of surface groups accessible for subsequent coupling reactions. Particularly attractive for the quantification of these groups are spectrophotometric and fluorometric assays, which can be read out with simple instrumentation. In this respect, we present here a novel family of cleavable spectrophotometric and multimodal reporters for conjugatable amino and carboxyl surface groups on nano- and microparticles. This allows determination of particle-bound labels, unbound reporters in the supernatant, and reporters cleaved off from the particle surface, as well as the remaining thiol groups on particle, by spectrophotometry and inductively coupled optical emission spectrometry (³²S ICP-OES). Comparison of the performance of these cleavable reporters with conductometry and conventional labels, utilizing changes in intensity or color of absorption or emission, underlines the anal. potential of this versatile concept which elegantly circumvents signal distortions by scattering and encoding dyes and enables straightforward validation by method comparison. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Application of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Structural determinants of the stability of enzyme-responsive polyion complex nanoparticles targeting Pseudomonas aeruginosa’s elastase was written by Insua, Ignacio;Petit, Marion;Blackman, Lewis D.;Keogh, Robert;Pitto-Barry, Anais;O’Reilly, Rachel K.;Peacock, Anna F. A.;Krachler, Anne Marie;Fernandez-Trillo, Francisco. And the article was included in ChemNanoMat in 2018.SDS of cas: 38183-12-9 This article mentions the following:

Here, we report how the stability of polyion complex (PIC) particles containing Pseudomonas aeruginosa’s elastase (LasB) degradable peptides and antimicrobial poly(ethylene imine) is significantly improved by careful design of the peptide component. Three LasB-degradable peptides are reported herein, all of them carrying the LasB-degradable sequence -GLA- and for which the number of anionic amino acids and cysteine units per peptide were systematically varied. Our results suggest that while net charge and potential to cross-link via disulfide bond formation do not have a predictable effect on the ability of LasB to degrade these peptides, a significant effect of these two parameters on particle preparation and stability is observed A range of techniques has been used to characterize these new materials and demonstrates that increasing the charge and crosslinking potential of the peptides results in PIC particles with better stability in physiol. conditions and upon storage. These results highlight the importance of mol. design for the preparation of PIC particles and should underpin the future development of these materials for responsive drug delivery. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9SDS of cas: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Spectrofluorometric determination of alogliptin an antidiabetic drug in pure and tablet form using fluorescamine, a fluorogenic agent: application to content uniformity test was written by Derayea, Sayed M.;Gahlan, Ahmed A.;Omar, Mahmoud A.;Saleh, Gamal A.;Haredy, Ahmed M.. And the article was included in Luminescence in 2020.Related Products of 38183-12-9 This article mentions the following:

Alogliptin is an antidiabetic drug that belongs to a group called dipeptidyl peptidase-4 enzyme inhibitors. As the drug contains a primary amino group in its structure, it readily reacts with fluorescamine in slightly alk. medium (borate buffer, pH 8.8) to form a highly fluorescent product. Emission of this product was measured at 477 nm (λex = 387 nm). The linear range between the fluorescence intensity and the drug concentration was 0.1-0.5μg ml-1 with a good correlation coefficient (0.9986). Limits of detection and quantitation were 22 and 72 ng ml-1, resp. Guidelines of the International Conference for Harmonisation were followed to validate the developed method with acceptable results. Alogliptin content was determined successfully in its com. dosage form using the fluorescamine method with good recovery (98.60-101.26%). The method has excellent levels of accuracy and precision compared with the reported method as assessed using Student’s t-test and Fisher’s exact test. The method was applied successfully for the content uniformity test with high recovery and low relative standard deviation. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Related Products of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and biological activities of pyrazolinobenzofuro[3,2-d]pyridimidines was written by Basawaraj, Raga;Goled, S. N.;Khandre, Omakar;Sangapure, S. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2011.Name: 3-Aminobenzofuran-2-carboxamide This article mentions the following:

2-(2,4,6-Trimethoxyphenyl/α-naphthyl)-4-hydrazinobenzofuro[3,2-d]pyrimidines 5,6 were prepared by nucleophilic substitution of 2-(trimethoxyphenyl/α-naphthyl)-4-chlorobenzofuro[3,2-d]pyrimidines 3,4 with N₂H₄.H₂O in MeOH. The reaction of 2-substituted 4-hydrazinobenzofuro[3,2-d]pyrimidines 5,6 with Ac₂CH₂, NCCH₂CO₂Et, or AcCH₂CO₂Et in NaOEt furnished pyrazolyl- and pyrazolinylbenzofuro[3,2-d]pyrimidines. These compounds exhibited antimicrobial and anti-inflammatory activity. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Name: 3-Aminobenzofuran-2-carboxamide).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: 3-Aminobenzofuran-2-carboxamide

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of some biologically active 2&2,2-disubstituted 1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines and their reactions was written by Basavaraja, K. M.;Patil, V. M.;Agasimundin, Y. S.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2007.SDS of cas: 54802-10-7 This article mentions the following:

The condensation of 3-amino-2-carboxamide (I) with various aldehydes in the presence of hydrochloric acid gave the corresponding 2-aryl-1,2,3,4-tetrahydro-4-oxobenzofuro[3,2-d]pyrimidines II (X = O; R¹ = H; R² = Ph, 4-NO₂C₆H₄, 4-MeOC₆H₄, furyl). Compound I was converted into the required intermediate thiocarboxamide by the reaction with phosphorus pentasulfide in anhyd pyridine. The acid-catalyzed condensation of the thiocarboxamide with various ketones afforded the anticipated 2,2-dialkyl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R¹ = R² = Me; R¹ = Me, R² = Et; R¹ = R² = Et; R¹ = Me, R² = iBu), and with various aromatic aldehydes under similar conditions furnished the resp. 2-aryl-1,2,3,4-tetrahydro-4-thiobenzofuro[3,2-d]pyrimidines II (X = S; R¹ = H; R² = Ph, 4-NO₂C₆H₄, 4-MeOC₆H₄, furyl) in good yields. The methylation of the tetrahydrothiobenzofuro[3,2-d]pyrimidines led to the formation of a product which was found to be identical with 3-aminobenzofuran-2-carbonitrile, which has already been prepared in this laboratory Compounds II (X = S; R¹ = R² = Me; R¹ = Me, R² = Et; R¹ = R² = Et; R¹ = Me, R² = iBu; R¹ = H, R² = 4-OMeC₆H₄) underwent displacement by morpholine or piperidine to produce the resp. derivatives III (X = CH₂ or O). The synthesis of 1,2,3,4-tetrahydro-2-oxo-4-thiobenzofuro[3,2-d]pyrimidine (IV) and displacement of the mercapto group to produce the corresponding cyclic amine-substituted compounds was also investigated. The structures of all the compounds were well supported by spectral and anal. data. Some of the compounds exhibited moderate to appreciable antibacterial activity against S. aureus and E. coli. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7SDS of cas: 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Correction: A convenient, bio-inspired approach to the synthesis of multi-functional, stable fluorescent silica nanoparticles using poly(ethylene-imine) [Erratum to document cited in CA168:250087] was written by Bauer, Christina A.;Chi, Gregory;Likens, Olivia Q.;Brown, Sandra E.. And the article was included in Nanoscale in 2017.Category: benzofurans This article mentions the following:

The middle initial of the last author is incorrect in the published article. The correct name is “Sandra E. Brown” and the corrected list of authors for this paper is as shown. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Category: benzofurans).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem