Simple exploration of 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various fields.

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(i)3-Hydroxy-4,6-dichloro-1,3-dihydro-3-(benzofuran-5-yl)indole-2-one2.25 g of magnesium for a Grignard reaction in 15 ml of anhydrous THF are placed in a round-bottomed flask equipped with a mechanical stirrer, and under a stream of nitrogen.A mixture of 13.6 g of 5-bromobenzofuran in 35 ml of anhydrous THF is then added.The mixture is stirred for one hour, followed by addition of a solution of 5 g of 4,6-dichloro-1H-indole-2,3-dione in 50 ml of anhydrous THF.The mixture is stirred at room temperature for 4 hours 30 minutes.Water is added and the resulting mixture is extracted with ethyl acetate.The organic phase is separated out, dried over Na2SO4, filtered and evaporated under vacuum.The residue is taken up in ethyl acetate and washed with 1N sodium hydroxide solution.The organic phase is dried over Na2SO4, filtered and evaporated under vacuum.The solid is taken up in ethyl ether and filtered off. 4.2 g of expected product are obtained., 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI; US2011/312972; (2011); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 23145-07-5

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3. Synthesis of benzofuran-5-sulfonyl chloride. Isopropyl iodide (15.0 mmol) was added dropwise to a suspension of iodine (0.12 mmol), magnesium (30.0 mmol) in tetrahydrofuran (25 mL). After 15 min, a solution of 5- bromobenzofuran (15.2 mmol) in tetrahydrofuran (25 mL) was added dropwise and the reaction mixture was heated at reflux for 1 h. The mixture was cooled to -30 0C and sulfonyl chloride was bubbled through the reaction mixture for 10 min. The mixture was maintained for 30 min whereupon sulfuryl chloride (15.1 mmol) was added dropwise while cooling to -30 to -40 0C. The resulting solution was maintained for an additional 10 min and was allowed to warm to rt. The insoluble solids were removed by filtration and the filtrate was concentrated. The residue was diluted with dichloromethane (150 mL), washed with brine (3 x 100 mL), dried (sodium sulfate), and concentrated. The residue was purified by Flash chromatography (100/1 to 50/1 petroleum ether/ethyl acetate) to provide benzofuran-5-sulfonyl chloride in 15percent yield as a white solid. Data: 1H NMR (CDCl3) delta 8.37 (s, IH), 8.00 (d, IH), 7.84 (s, IH), 7.44 (d, IH), 6.97 (s, IH). LC/MS (ES) m/z 286 [M+BnH-l]+., 23145-07-5

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; SCHUMACHER, Richard, A.; TEHIM, Ashok; XIE, Wenge; WO2010/24980; (2010); A1;,
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Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 16859-59-9

16859-59-9, As the paragraph descriping shows that 16859-59-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16859-59-9,3-Hydroxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of phthalaldehydic acid 2 (3 mmol) and furan 3 (2.7 mmol;3.3 mmol for 4ab) in acetic acid (8 mL for 4aa, ab?ad; 13 mL for 4ba, ea, fa;20 mL for 4ca, da; 25 mL for 4ga) at room temperature CuBr2 (1.35 mmol;0.27 mmol for 4ea; 0.54 mmol for 4ab) was added. The resulting reactionmixture was stirred for 24 h (18 h for 4aa; 48 h for 4fa) and after reactioncompletion (TLC) was poured into water (150 mL), neutralized with NaHCO3and extracted using DCM (3 40 mL). The combined organic extracts weredried over anhydrous Na2SO4, and the solvent was removed under vacuum.The residue was purified by flash chromatography over silica gel using DCM/petroleum ether (1:1.5, v/v then 2:1, v/v (1:3, v/v for 4ad; 1:6, v/v for 4ac) aseluent and recrystallized from DCM/petroleum ether to afford 3-(fur-2-yl)-3Hisobenzofuran-1-ones 4aa?ad.

16859-59-9, As the paragraph descriping shows that 16859-59-9 is playing an increasingly important role.

Reference£º
Article; Shcherbinin, Vitaly A.; Shpuntov, Pavel M.; Konshin, Valery V.; Butin, Alexander V.; Tetrahedron Letters; vol. 57; 13; (2016); p. 1473 – 1475;,
Benzofuran – Wikipedia
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Some tips on 17403-47-3

As the paragraph descriping shows that 17403-47-3 is playing an increasingly important role.

17403-47-3, 5-Nitro-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Preparation of 5-amino-2,3-dihydrobenzofuran [Show Image] The product (1 g, 6.1 mmol) obtained in Step 1, Raney Ni (0.1 g) and MeOH(10 mL) were used for hydrogenation at room temperature and hydrogen pressure of 50 PSI, until the reaction was finished. The catalyst was removed by filtration, the fitrate was concentrated under vacuum to obtain a product (800 mg, 97.2%)., 17403-47-3

As the paragraph descriping shows that 17403-47-3 is playing an increasingly important role.

Reference£º
Patent; Xuanzhu Pharma Co., Ltd.; EP2532665; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 28418-88-4

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28418-88-4,4-Iodoisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

(1-1) Production of N-(4-methyl-3-trifluoromethylisoxazol-5-yl)-3-iodophthalimide In 20 ml of acetic acid, 0.6 g of 3-iodophthalic anhydride and 0.44 g of 5-amino-4-methyl-3-trifluoromethyl-isoxazole were dissolved and reacted for 9 hours with heating under reflux. After completion of the reaction, the solvent was distilled off under reduced pressure, and the residue was dissolved in ethyl acetate, washed with dilute hydrochloric acid, saturated aqueous solution of sodium bicarbonate and saturated aqueous solution of sodium chloride, and then dried on sodium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography using a 3/1 mixture of hexane and ethyl acetate as an eluent to obtain 0.71 g of the objective product. Property: m.p. 105C; Yield: 69%

28418-88-4, 28418-88-4 4-Iodoisobenzofuran-1,3-dione 282071, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Nihon Nohyaku Co., Ltd.; EP1193254; (2002); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 16859-59-9

16859-59-9, The synthetic route of 16859-59-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16859-59-9,3-Hydroxyisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

General procedure: 3.3 Mmol (0.5 g) o-formylbenzoic acid or opianic acid (0.62 g.) was triturated with 2 mL of conc. H2SO4 until dissolution and then was added 0.7 g (3.6 mmol) sodium carbamoylmethyl thiosulfate, triturated again and left for 12 hours at r.t. The reaction mixture was treated with 25 mL of cold water. The solid product was filtered off, washed with water and dried.

16859-59-9, The synthetic route of 16859-59-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ukhin, L.Yu.; Akopova; Bicherov; Kuzmina; Morkovnik; Borodkin; Tetrahedron Letters; vol. 52; 42; (2011); p. 5444 – 5447;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 174775-48-5

The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 1-(2,3-dichlorophenyl) piperazine (entry 3) (5 g, 0.022 mol) in THF (25 mL) was added formamide (2.4 g, 0.054 mol).To the above mixture was added sodium methoxide (30% solution in methanol, 9.7 g, 0.054 mol) and stirred at room temperature for 6 h. The solvent was evaporated and the reaction mixture was diluted with water and extracted with dichloromethane (50 mL ¡Á 2). The dichloromethane layer was washed with 25 mL of dilute HCl and concentrated under reduced pressure to give the product (5.1 g, 92%)., 174775-48-5

The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Joseph, Sony; Das, Prasenjit; Srivastava, Bindu; Nizar, Hashim; Prasad, Mohan; Tetrahedron Letters; vol. 54; 8; (2013); p. 929 – 931;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 37418-88-5

The synthetic route of 37418-88-5 has been constantly updated, and we look forward to future research findings.

37418-88-5, 4-Hydroxyisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3-hydroxyphthalic anhydride (543 mg, 3.31 mmol), 4-methoxybenzylamine (0.43 mL, 3.31 mmol) and acetic acid (3 mL) was heated at 1000C for 4 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (760 mg, 81 percent). 1H NMR (DMSOd6) 11.03 (1 H, s), 7.61 (1H, dd), 7.28 (1 H, d), 7.23-7.19 (3H, m), 6.89-6.86 (2H, m), 4.63 (2H, s), 3.71 (3H, s). MS: [M-H+] 282., 37418-88-5

The synthetic route of 37418-88-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTEX THERAPEUTICS LIMITED; WO2008/44041; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 27550-59-0

27550-59-0, As the paragraph descriping shows that 27550-59-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27550-59-0,5-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

6th Stage: 4-[11-(acryloyl-methyl-amino)-undecyloxy]phthalic Acid (AAUPA) 4-hydroxyphthalic anhydride (6.70 g; 40.8 mmol), BHT (10 mg) and N-(11-bromoundecyl)-N-methyl acrylamide (13.00 g; 40.8 mmol) were dissolved in N,N-dimethylformamide (100 ml). Potassium carbonate (5.64 g; 40.8 mmol) was added. The yellow suspension was stirred at RT. Water (200 ml) was added to the reaction mixture after 20 d and the whole stirred for 1 h at RT. An oily white solid precipitated from the initially cloudy solution. The solvent was decanted off. The residue was dissolved in dilute aqueous Na2CO3 solution (5%; 100 ml). The milky/cloudy aqueous phase was washed with MtBE (5*100 ml). Diluted hydrochloric acid (2N, 100 ml) was added to the water phase (pH=1) and extraction with MtBE (8*100 ml) took place. The combined extracts were dried over Na2SO4, filtered and concentrated on the rotary evaporator. Chloroform (150 ml) was added to the residue and the whole stirred at RT. After 20 h the suspension was filtered. The filtration residue was washed with chloroform (50 ml) and discarded. The filtrate was concentrated on the rotary evaporator. The residue was dissolved in chloroform (50 ml). Acetonitrile (50 ml) was added. After 72 h storage at -18 C. the solvent was decanted off and the residue dried under a fine vacuum. 3.84 g (9.2 mmol; 22% yield) of a white solid was obtained (melting point: 95 C.), which dissolves very well e.g. in ethanol or acetone. 1H-NMR (DMSO-d6, 400 MHz): delta (2 isomers)=1.15-1.35 (m, 12H), 1.36-1.50 (m, 4H), 1.68-1.75 (m, 2H), 2.86 (s, 1.7H), 3.00 (s, 1.3H), 3.29-3.36 (m, 2H), 4.04 (t, 2H; J=6.4 Hz), 5.61-5.65 (m, 1H), 6.06-6.13 (m, 1H), 6.72 (dd, 1H; J=10.7 Hz, 16.9 Hz), 7.03-7.08 (m, 2H), 7.73 (d, 1H; J=8.4 Hz), 12.89 (br, 2H). 13C-NMR (DMSO-d6, 100 MHz): delta=24.3, 24.8, 25.2, 25.5, 27.3, 27.5, 27.6, 27.7, 27.8, 27.9, 32.2, 33.7, 45.8, 47.8, 66.9, 112.3, 114.2, 121.3, 125.6, 127.2, 127.6, 130.1, 136.0, 159.7, 164.0, 166.2, 168.1.

27550-59-0, As the paragraph descriping shows that 27550-59-0 is playing an increasingly important role.

Reference£º
Patent; IVOCLAR VIVADENT AG; BOCK, Thorsten; FISCHER, Urs Karl; LAMPARTH, Iris; MOSZNER, Norbert; RHEINBERGER, Volker; US2013/90404; (2013); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 4265-16-1

The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.

4265-16-1, Benzo[b]furan-2-carboxaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of benzofuran-2-carbaldehyde (3.0 g, 20.5 mmol) and hydroxylamine hydrochloride (2.1 g, 30.8 mmol) in dichloromethane was added triethylamine (3.1 g, 30.8 mmol) slowly at 0 C. The reaction mixture was allowed to stir at room temperature for 3 hours. Once complete by TLC analysis the reaction mixture was washed with water (2 x 20 mL) and brine before being dried over anhydrous sodium sulfate. After concentration, the crude product was purified by column chromatography [petroleum ether/ethyl acetate=15: l] to afford compound B- 104 (3.0 g, 91% yield) as a yellow solid. LCMS: (ES+) m/z (M+H)+ = 162.2, tR=0.605 and 0.653., 4265-16-1

The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem