Tag: M.W=300-400

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine( cas:767291-67-8 ) is researched.Synthetic Route of C20H42N2.Barker, Graeme; McGrath, Julia L.; Klapars, Artis; Stead, Darren; Zhou, George; Campos, Kevin R.; O’Brien, Peter published the article 《Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc Pyrrolidine: In Situ React IR Spectroscopic Monitoring, Scope, and Synthetic Applications》 about this compound( cas:767291-67-8 ) in Journal of Organic Chemistry. Keywords: palladium catalyst enantioselective arylation BOC pyrrolidine IR spectroscopy. Let’s learn more about this compound (cas:767291-67-8).

A comprehensive study of the enantioselective Pd-catalyzed α-arylation of N-Boc pyrrolidine, e.g. I, has been carried out. The protocol involves deprotonation of N-Boc pyrrolidine using s-BuLi/(-)-sparteine in TBME or Et2O at -78 °C, transmetalation with ZnCl2 and Negishi coupling using Pd(OAc)2, t-Bu3P-HBF4 and the aryl bromide. This paper reports several new features including in situ React IR spectroscopic monitoring of the process; use of (-)-sparteine and the (+)-sparteine surrogate to access products with opposite configuration; development of a catalytic asym. lithiation-Negishi coupling reaction; extension to a wide range of heteroaromatic bromides; total synthesis of (R)-crispine A, (S)-nicotine and (S)-SIB-1508Y via short synthetic routes; and examples of α-vinylation of N-Boc pyrrolidine using vinyl bromides exemplified by the total synthesis of naturally occurring (+)-maackiamine (thus establishing its configuration as (R)). In this way, the full scope and limitations of the methodol. are delineated.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Acute renal insufficiency following the therapeutic application of phenylbutazone》. Authors are Streicher, E..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Electric Literature of C19H19N2NaO2. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Normal renal function was restored by means of extracorporeal dialysis in 4 cases of acute renal insufficiency apparently resulting from the administration of the phenylbutazone-containing drugs, Butazolidine, Delta-butazolidin, Irgapyrine, and Tomanol. A review was given of this and other side-reactions resulting from the administration of this class of drug. 71 references.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Five years’ experience with the evaluation of diuretic agents. Author is Swartz, Charles; Seller, Robert; Fuchs, Morton; Brest, Albert N.; Moyer, John H..

Evaluation of 12 diuretics and 2 combinations of diuretics in normal hospitalized patients permitted only separation of drugs into a few overlapping categories of potency. The combination of a mercurial and a thiazide caused significantly greater Na excretion than any other drug used alone. No single diuretic was significantly more potent than all the others.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effect of 6-azauridine on the contractile responses of the isolated ileum of the guinea pig to drugs and to coaxial stimulation》. Authors are Seferna, I.; Lukomskaya, N.; Kadlec, O.; Janku, I..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Through the article, more information about this compound (cas:129-18-0) is conveyed.

Small concentrations of 6-azauridine augmented the contractions of the isolated guinea pig ileum to acetylcholine, nicotine, histamine, barium chloride, and coaxial stimulation. High concentrations partially inhibited all the responses. After prolonged contact with high concentrations of 6-azauridine, the antispasmogenic effect persisted long after washing out the compound The acetylcholine output did not change under these conditions. Comparison of the actions of 6-azauridine with those of papaverine is made and the possible mechanisms of action are discussed.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Anti-inflammatory drug actions on allergic responses in guinea-pig skin, the main research direction is allergy inflammation inhibitor; immunosuppressant inflammation inhibitor.Application of 129-18-0.

Five non-steroidal anti-inflammatory drugs (NSAIDs) (indomethacin [53-86-1], naproxen [22204-53-1], meclofenamic acid [644-62-2], feprazone Na salt [69227-53-8] and phenylbutazone Na salt [129-18-0] and three glucocorticosteroids (dexamethasone Na phosphate [2392-39-4], hydrocortisone Na phosphate [6000-74-4] and prednisolone Na phosphate [125-02-0]) were tested as local inhibitors of increased vascular permeability in guinea-pig skin. Lesions were induced by histamine or by antigen to evoke type I (passive cutaneous anaphylaxis), type III (reverse passive Arthus) and type IV (delayed hypersensitivity) allergic reactions. NSAIDs and glucocorticosteroids caused either weak, inconsistent inhibition or slight, high-dose inhibition of the response to histamine. None of the drugs tested showed significant inhibition of the type IV response. The NSAIDs caused dose-related inhibition of both type I and type III responses whereas glucocorticosteroids were ineffective. Maximum inhibition with the NSAIDs was never greater than 50-60%. Feprazone, meclofenamic acid and indomethacin were the most potent inhibitors of histamine, PCA, and Arthus responses, resp. The possible significance of the effects of these antiinflammatory agents on vascular permeability is discussed.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The carrageenin-induced abscess as a new test for antiinflammatory activity of steroids and nonsteroids》. Authors are Benitz, K. F.; Hall, L. M..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Electric Literature of C19H19N2NaO2. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The exptl. abscesses were produced by single injections of 0.5 ml. 2% aqueous solution of carrageenin (I) subcutaneously 25-30 mm. rostral of the tail root of female rats. The I abscesses did not alter the behavior of the rats or their body weight The action of drugs against I-induced irritation was determined by giving 1/2 the dose intraperitoneally or orally immediately after the I and the remaining 1/2 approx. 6 hrs. later. The rats were sacrificed 24 hrs. after the I injections and a “”tail pouch”” containing the abscess dissected out for weighing. Antiinflammatory effects were found (decrease in the weight of abscess produced) for Na salicylate, phenylbutazone as the Na salt (II), II plus aminopyrine, hydrocortisone, prednisolone, and triamcinolone. There were differences in the activity of the different drugs and drug combinations but the dose, response curves were essentially linear in each case. The results demonstrated the general utility of the I injection method, and I offered some advantages (discussed) over HCHO or turpentine as an irritation-producing agent. The I did not produce necroses. Possible misleading results due to the so-called counter-irritant effect could be considerably decreased by oral administration of the drugs. The results are interpreted in relation to previous reports on tests for agents which inhibit inflammations. 30 references.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Farmaco, Edizione Scientifica called Pharmacology of p-hydroxypropiophenone sulfate, Author is Setnikar, I.; Murmann, W., which mentions a compound: 129-18-0, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2, Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The Na salt has low toxicity in acute and chronic application. It is well tolerated when injected locally in not too concentrated solutions It does not inhibit the pituitary secretion of adrenocorticotropin in the normal animal or in stress of variable severity. It neither inhibits the secretion of somatotropic hormone nor has any influence on the normal growth. It does, however, inhibit the secretion of gonadotropin by the pituitary if this secretion is abnormally high. It also inhibits thyrotropic hyperfunction of the hypophysis if a hyperfunction exists. The antigonadotropic and antithyrotropic action does not occur peripherally, but it has a central point of attack either on the hypophysis or on the centers that govern this gland. The effect on the pituitary is not caused by an estrogenic effect.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: C19H19N2NaO2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Antigranuloma and thymolytic activity of certain drugs. Author is Silvestrini, B.; Lisciani, R.; Scorza Barcellona, P..

The possibility that the antigranuloma action of corticosteroids is mediated by the thymus gland was studied in intact, thymectomized, and adrenalectomized rats having granulomas induced by cotton-pellet implantation. In intact rats, s.c. injected cortisone acetate (I) (30 and 50 mg./kg.) inhibited body weight increases and reduced the weights of the granuloma, thymus gland, and spleen. The effects of I were dose dependent; at 5 mg./kg., s.c. body growth and granuloma were inhibited, whereas an oral dose of 50 mg./kg. inhibited the granuloma and reduced the weights of the thymus gland and spleen. Na phenylbutazone and benzydamine-HCl selectively inhibited granuloma, but even doses of 50 mg./kg., s.c., and 80 mg./kg., orally, of Na phenylbutazone and up to 500 mg./kg., orally, of benzydamine-HCl did not significantly reduce thymus and spleen weights Testosterone (10 and 50 mg./kg., s.c.) reduced the weight of the thymus gland at the lower dosage and at the higher dose reduced that of the granuloma. Morphine sulfate (5 and 20 mg./kg.) inhibited the granuloma, thymus, and thyroid gland weights and increased that of the adrenal gland. In the adrenalectomized rats, I and testosterone exhibited biol. activity, whereas morphine sulfate was inactive. In thymectomized animals, the granuloma, body, and internal organ weights were similar to those of controls and I was still active. 18 references.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The composite expectorant Expectin》. Authors are Soltesz, Jeno; Bako, Sandor.The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Category: benzofurans. Through the article, more information about this compound (cas:129-18-0) is conveyed.

The use of raw glycyrrhizin (I) improves the quality of the preparation Expectin (II). II is prepared from extracts of primrose root and thyme herbage by the addition of I. No reduction in the hemolytic index was discovered after 1 1/2 years.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Journal of Thermal Analysis and Calorimetry called Synthesis, spectral characterization and thermal studies of zirconyl complexes of biologically active molecules, Author is Jisha, K. R.; Suma, S.; Sudarsanakumar, M. R., the main research direction is zirconyl hippuric acid phenylbutazone chloro hydroxo preparation thermolysis; pyrazolidinedione butylphenyl zirconyl chloro hydroxo preparation thermolysis; second harmonic generation zirconyl hippuric acid chloro hydroxo.Application of 129-18-0.

Zirconyl complexes of hippuric acid (C9H9NO3, hipH) and monophenylbutazone (4-butyl-1-phenyl-3,5-pyrazolidinedione, MPB) were prepared using ZrOCl2·8H2O and ZrO(NO3)3·xH2O and characterized by elemental anal., molar conductance measurement and IR, UV-Vis and NMR spectral methods. Thermal decomposition behavior was studied by thermogravimetry. The second harmonic generation (SHG) conversion efficiency of hippuric acid complexes was also studied.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem