Brief introduction of 767291-67-8

This literature about this compound(767291-67-8)Synthetic Route of C20H42N2has given us a lot of inspiration, and I hope that the research on this compound((1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine) can be further advanced. Maybe we can get more compounds in a similar way.

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine( cas:767291-67-8 ) is researched.Synthetic Route of C20H42N2.Barker, Graeme; McGrath, Julia L.; Klapars, Artis; Stead, Darren; Zhou, George; Campos, Kevin R.; O’Brien, Peter published the article 《Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc Pyrrolidine: In Situ React IR Spectroscopic Monitoring, Scope, and Synthetic Applications》 about this compound( cas:767291-67-8 ) in Journal of Organic Chemistry. Keywords: palladium catalyst enantioselective arylation BOC pyrrolidine IR spectroscopy. Let’s learn more about this compound (cas:767291-67-8).

A comprehensive study of the enantioselective Pd-catalyzed α-arylation of N-Boc pyrrolidine, e.g. I, has been carried out. The protocol involves deprotonation of N-Boc pyrrolidine using s-BuLi/(-)-sparteine in TBME or Et2O at -78 °C, transmetalation with ZnCl2 and Negishi coupling using Pd(OAc)2, t-Bu3P-HBF4 and the aryl bromide. This paper reports several new features including in situ React IR spectroscopic monitoring of the process; use of (-)-sparteine and the (+)-sparteine surrogate to access products with opposite configuration; development of a catalytic asym. lithiation-Negishi coupling reaction; extension to a wide range of heteroaromatic bromides; total synthesis of (R)-crispine A, (S)-nicotine and (S)-SIB-1508Y via short synthetic routes; and examples of α-vinylation of N-Boc pyrrolidine using vinyl bromides exemplified by the total synthesis of naturally occurring (+)-maackiamine (thus establishing its configuration as (R)). In this way, the full scope and limitations of the methodol. are delineated.

This literature about this compound(767291-67-8)Synthetic Route of C20H42N2has given us a lot of inspiration, and I hope that the research on this compound((1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem