Tag: M.W=300-400

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Further evidence for the involvement of kinin in anaphylactic shock in the rat.Related Products of 129-18-0.

Na phenylbutazone, soybean trypsin inhibitor, or the concomitant administration of ascorbic acid and mepyramine protected rats against anaphylactic shock at 10 days after sensitization but gave no protection against anaphylaxis at 20 days. During anaphylactic shock in rats at 10 days after sensitization, the plasma bradykinin and bradykininogen levels, as well as those in the intestinal lumen and peritoneal cavity, were markedly raised. The results support the hypothesis that there are 2 phases in anaphylaxis in the rat-an early phase in which bradykinin is a mediator and against which phenylbutazone or soybean trypsin inhibitor or the mixture of ascorbic acid and mepyramine, give protection, and a late phase which does not involve bradykinin.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about β-Lipoproteins: possible plasma transport proteins for basic drugs. Author is Vallner, J. J.; Chen, L..

The interactions between β-lipoprotein and drugs, as measured by difference spectrophotometry, apparently occurred at more than a single class of sites on the β-lipoprotein. β-Lipoprotein may act in conjunction with albumin in the plasma transport of basic or cationic drugs.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aarsen, P. N.; Zeegers, A. published the article 《Effects of histamine, 5-hydroxytryptamine, and bradykinin on the vascular system of isolated lungs of the guinea pig and the influence of phenylbutazone on these effects》. Keywords: histamine vasoconstriction; serotonin vasoconstriction; bradykinin vasoconstriction; phenylbutazone vasoconstriction.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).Application of 129-18-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

In isolated lungs of the guinea pig perfused through pulmonary artery repeated doses of histamine acid phosphate [51-74-1] progressively increased pulmonary arterial pressure and decreased fluctuations in tracheal pressure. Phenylbutazone Na [129-18-0] almost completely abolished the effect of histamine on the arterial pressure and suppressed the progression of the effect on tracheal pressure. The effects of 5-hydroxytryptamine creatinine sulfate [971-74-4] and bradykinin [58-82-2] did not show such progression. Further experiments indicated that repeated administration of histamine causes an accumulation of fluid in the lungs probably mainly in the interstitial spaces, which results in an inhibition of the tracheal pressure fluctuations. Phenylbutazone prevents this effect by suppressing the vasoconstrictor action of histamine without affecting the increased vascular permeability.

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Benzofuran – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 767291-67-8, is researched, Molecular C20H42N2, about Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines, the main research direction is enantioselective addition methyllithium aromatic imine diamine ligand.Computed Properties of C20H42N2.

A new tertiary pseudo C2-sym. diamine derived from (1S,2S)-(+)-pseudoephedrine was synthesized and tested in the enantioselective addition of methyllithium on different aromatic imines. A comparative study with a similar C2-sym. ligand derived from the cyclohexane diamine showed better reactivity and enantioselectivity up to 91%.

Compounds in my other articles are similar to this one((1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine)Computed Properties of C20H42N2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Kinetics of drug decomposition. Part 38. Hydrolysis and autoxidation of sodium phenylbutazone and aminophenazone in binary kinetic system, published in 1976, which mentions a compound: 129-18-0, Name is Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, Molecular C19H19N2NaO2, Reference of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide.

The kinetics of hydrolysis and autoxidation of Na phenylbutazone (Na I)(II) [129-18-0] and aminophenazone (III) [58-15-1] in binary sysytems (e.g., Rheumopyrin [8066-94-2] and Irgapyrin [8064-79-7]) was investigated in NH3-AcOH, Carmody and Wefford buffers at different buffer concentration, pH, ionic strengths, and temperature The degradation of II in the presence of III followed 1st order reaction kinetics. III degradation at low concentration (in buffers-Ph 7.13-10.0) was possible only under high excess O. High concentrations of II and III (15%) can be considered as a system stabilizing the degradation, which was regulated by the alk. character of II (pH = 8.6 to 15% II). The lack of effect of different kinds of buffers, ionic strength, and pH on the rate constant of II hydrolysis, qualified the process as a spontaneous reaction initiated by the attack of water mols. The degradation parameters of II in the presence of III, compared with those in its absence, confirm the stabilizing effect of III. In the autoxidation and hydrolysis reaction of II, the changes in the reaction rate depended on the pH. At pH 7.13, the degradation was 3 times faster than at pH 12.07. The activation energy values for the hydrolysis of II without III were lower by 19240 J/mole and for the autoxidation and hydrolysis by 2700 J/mole than those for III present in the reaction medium.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The effect of carboxylic acid esters on the experimental hyperkinesis elicited by nicotine》. Authors are Liberman, S. S..The article about the compound:Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-idecas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+]).Product Details of 129-18-0. Through the article, more information about this compound (cas:129-18-0) is conveyed.

A study was made of the presence of a central nicotinolytic activity in the esters of diphenylacetic acid and its derivatives, which enhanced the resistance to nicotine and lowered the hyperkinesis produced by nicotine. Sixteen compounds were investigated. The dimethylaminoethyl ester of diphenylacetic acid proved the most active. In doses of 25 mg./kg. of body weight this compound prevented the death of the animals from nicotine and lowered the nicotinic hyperkinase to a considerable degree. The esters of benzilic acid, 2-quinuclidylmethyl, 4-pyridylmethyl, and isopropylaminoethyl esters of diphenylacetic acid proved ineffective in preventing nicotinic hyperkinesis. The results of the experiments led the author to conclude that the substitution of a H atom by a methyl group in a hydrocarbon radical which unites phenyl radicals has no substantial effect on the nicotinolytic activity of the compounds; the substitution of a hydroxyl group completely negated the nicotinolytic activity of the compounds

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthetic Route of C19H19N2NaO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Effect of meseclazone and other non-steroidal antiinflammatory drugs on isolated tracheal chain tone. Author is Diamantis, William; Melton, John L.; Sofia, R. Duane; Ciofalo, Vincent B..

Concentration-dependent relaxation of the isolated guinea pig tracheal chain was produced by the following nonsteroidal antiinflammatory drugs: naproxen [22204-53-1] > ibuprofen [15687-27-1] > diflunisal [22494-42-4] > tolmetin [26171-23-3] ≃ fenoprofen [29679-58-1] ≃ indomethacin [53-86-1] > phenylbutazone Na [129-18-0] > meseclazone (I) [29053-27-8] > 5-chlorosalicylic acid [321-14-2] > aspirin [50-78-2]. All these drugs were less potent than isoproterenol-HCl. This relaxation may be related to inhibition of prostaglandin synthesis, but since the relative potencies of the drugs in the tracheal test did not necessarily correspond to those in inhibiting prostaglandin synthetase in other tissues, other factors may be involved.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (1S,2S)-N1,N2-Bis(3,3-dimethylbutyl)-N1,N2-dimethylcyclohexane-1,2-diamine, is researched, Molecular C20H42N2, CAS is 767291-67-8, about Effect of Ligand Structure on the Asymmetric Cyclization of Achiral Olefinic Organolithiums. Author is Mealy, Michael J.; Luderer, Matthew R.; Bailey, William F.; Sommer, Michael Bech.

The ability of a large and chem. diverse set of 30 chiral ligands to effect asym. cyclization of 2-(N,N-diallylamino)phenyllithium (I), derived from N,N-diallyl-2-bromoaniline by low-temperature lithium-bromine exchange, has been investigated in an attempt to elucidate the structural motifs required to provide high enantiofacial selectivity in the ring closure. Although none of the ligands examined in this study afforded 1-allyl-3-methylindoline in significantly higher ee than previously observed for the cyclization of I in the presence of the benchmark ligand (-)-sparteine, several ligands, structurally unrelated to sparteine and available in either enantiomeric form, were found to match the utility of (-)-sparteine in this chem.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Article, Experientia called Specificity of the blood pressure reflex induced by bradykinin, kallidin, and met-kallidin in cats, Author is Wiegershausen, Burkhard; Klausch, B., the main research direction is BLOOD PRESSURE KININS; KININS BLOOD PRESSURE; ACETYLCHOLINES BLOOD PRESSURE; KALLIDINS BLOOD PRESSURE; BRADYKININS BLOOD PRESSURE.Recommanded Product: 129-18-0.

The synthetic kinins, bradykinin acetate (3.1-6.2 × 10-9M), kallidin acetate (2.8-5.6 × 10-9M), and met-kallidin acetate (6.1-12.2 × 10-9M), and acetylcholine chloride (2.2-4.4 × 10-7M), administered via the femoral artery in an isolated hindlimb of a cat, elicited vasoconstriction, a systemic blood pressure reflex, a stimulation of respiration, and contraction of the nictitating membrane. Atropine blocked the reflex due to acetylcholine, but not the reactions of the kinins. Na phenylbutazone (1.2-2.4 × 10-5M) blocked the reflex reactions of acetylcholine and the kinins, as well as the vasoconstrictor effect of histamine-2HCl and the kinins in the isolated hindlimb.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application In Synthesis of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Study of two new non-steroid antiinflammatory drugs having a pyrazole structure (LM 22070 and LM 22102). Author is Mizoule, J.; Le Fur, G.; Uzan, A..

Two derivatives from a new heteroarylacetic series, LM 22102 (I) [50270-32-1] and LM 22070 (II) [50270-33-2], were selected on the basis of their antiinflammatory, analgesic, and antipyretic properties. In the mouse, I and II, resp., were 15 and 30 times less active than indomethacin ethanolamine salt [71227-27-5] in Koster’s test, but they were 9 and 13 times less toxic than the reference drugs. In contrast, they were very active in the rat and the guinea pig. I was as active as indomethacin in the various tests . In vitro, its inhibition of prostaglandin synthetase [9055-65-6] in guinea pig lung was more powerful than that of indomethacin. Like all potent nonsteroid antiinflammatory drugs I had ulcerogenic activity, similar to that of indomethacin, which accounted for its acute oral toxicity in the rat. The activities of II were either the same as (antipyretic action) or inferior to (analgesic and antiinflammatory activity and inhibition of prostaglandin synthetase) that of indomethacin, but were always superior to those of phenylbutazone sodium salt [129-18-0]. Its ulcerogenic activity and oral acute toxicity in the rat are 2.5- and 3-fold weaker than those of indomethacin, resp.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem