Tag: M.W:100-200

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 90866-33-4, is researched, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3Journal, Cuihua Xuebao called Effective method for controlling the stereoselectivity in asymmetric reduction of β-oxo ester with yeast cells, Author is Yang, Zhonghua; Yao, Shanjing, the main research direction is oxoester asym reduction Saccharomyces enzyme inhibitor; stereoselective reduction oxoester Saccharomyces enzyme inhibitor.Quality Control of (R)-Ethyl 4-chloro-3-hydroxybutanoate.

Using the reduction of Et 4-chloro-3-oxobutanoate (COBE) to enantiomeric pure Et 4-chloro-3-hydroxybutanoate (CHBE) as the model reaction, the method for controlling the stereoselectivity of reduction of β-oxo esters by pretreatment of the yeast was studied. The primary technique was pretreatment of the yeast cells with enzyme inhibitors, such as allyl alc. and allyl bromide, for a period before asym. transformation of COBE. It was found that the stereoselectivity of the reduction reaction could be controlled to produce S-CHBE when the yeast cells were pretreated with allyl alc. The ee of S-CHBE was improved with increasing the concentration of allyl alc. and the pretreatment time. 95% for ee of S-CHBE could be reached when allyl alc. was 1 g/L and pretreatment time was 2 h. On the contrary, the pretreatment with allyl bromide could turn the stereoselectivity of this reduction reaction from S-CHBE to R-CHBE. Also the inhibitor concentration and pretreatment time had pos. effect on ee of R-CHBE. And the ee of R-CHBE could reach to 98 % when an appropriate condition was applied.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate(SMILESS: O=C(OCC)C[C@@H](O)CCl,cas:90866-33-4) is researched.Computed Properties of CAgF3O3S. The article 《Synthesis of ethyl (R)-4-chloro-3-hydroxybutanoate with recombinant Escherichia coli cells expressing (S)-specific secondary alcohol dehydrogenase》 in relation to this compound, is published in Bioscience, Biotechnology, and Biochemistry. Let’s take a look at the latest research on this compound (cas:90866-33-4).

The synthesis of Et (R)-4-chloro-3-hydroxybutanoate ((R)-ECHB) from Et 4-chloroacetoacetate was studied using whole recombinant cells of Escherichia coli expressing a secondary alc. dehydrogenase of Candida parasilosis. Using 2-propanol as an energy source to regenerate NADH, the yield of (R)-ECHB reached 36.6 g/l (more than 99% ee, 95.2% conversion yield) without addition of NADH to the reaction mixture

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Benzofuran – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Garcia-Urdiales, Eduardo; Rebolledo, Francisca; Gotor, Vicente researched the compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ).Name: (R)-Ethyl 4-chloro-3-hydroxybutanoate.They published the article 《Enzymatic ammonolysis of ethyl (±)-4-chloro-3-hydroxybutanoate. Chemoenzymatic syntheses of both enantiomers of pyrrolidin-3-ol and 5-(chloromethyl)-1,3-oxazolidin-2-one》 about this compound( cas:90866-33-4 ) in Tetrahedron: Asymmetry. Keywords: enzymic ammonolysis ethyl chlorohydroxybutanoate; chemoenzymic preparation pyrrolidinol chloromethyloxazolidinone enantiomer; lipase B catalysis ammonolysis kinetic resolution. We’ll tell you more about this compound (cas:90866-33-4).

Lipase B from Candida antarctica efficiently catalyzed the kinetic resolution of Et (±)-4-chloro-3-hydroxybutanoate through an ammonolysis reaction. With this methodol., both enantiomers of 4-chloro-3-hydroxybutanamide were prepared and converted into pyrrolidin-3-ol and 5-(chloromethyl)-1,3-oxazolidin-2-one by simple processes consisting of a reduction reaction and a Hofmann rearrangement, resp.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Isoquinolin-3-ol(SMILESS: OC1=CC2=C(C=N1)C=CC=C2,cas:134434-31-4) is researched.Safety of 1-(Bromomethyl)-4-ethylbenzene. The article 《Slow excited state phototautomerization in 3-hydroxyisoquinoline》 in relation to this compound, is published in Photochemical & Photobiological Sciences. Let’s take a look at the latest research on this compound (cas:134434-31-4).

In the present work we report the spectral and photophys. properties of 3-hydroxyisoquinoline in various protic/aprotic solvents. Our steady state and time resolved fluorescence data indicates that in the monomer form of 3HIQ phototautomerization can take place in the excited state through excited state intramol. proton, while as per earlier suggestions phototautomerization in 3HIQ occurs in dimer or complex (in the presence of acetic acid) form. Moreover, we find rather slow tautomerization (occurring on the nanosecond scale). It is found that proton transfer occurs both in the ground as well as excited states and is controlled by the polarity of the solvent.

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Benzofuran – Wikipedia,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about High-level expression of recombinant glucose dehydrogenase and its application in NADPH regeneration, the main research direction is recombinant glucose dehydrogenase NADPH regeneration Bacillus NADPH.Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate.

Two glucose dehydrogenase (E.C. 1.1.1.47) genes, gdh223 and gdh151, were cloned from Bacillus megaterium AS1.223 and AS1.151, and were inserted into pQE30 to construct the expression vectors, pQE30-gdh223 and pQE30-gdh151, resp. The transformant Escherichia coli M15 with pQE30-gdh223 gave a much higher glucose dehydrogenase activity than that with the plasmid pQE30-gdh151. Thus it was used to optimize the expression of glucose dehydrogenase. An approx. tenfold increase in GDH activity was achieved by the optimization of culture and induction conditions, and the highest productivity of glucose dehydrogenase (58.7 U/mL) was attained. The recombinant glucose dehydrogenase produced by E. coli M15 (pQE30-gdh223) was then used to regenerate NADPH. NADPH was efficiently regenerated in vivo and in vitro when 0.1 M glucose was supplemented concomitantly in the reaction system. Finally, this coenzyme-regenerating system was coupled with a NADPH-dependent bioreduction for efficient synthesis of Et (R)-4-chloro-3-hydroxybutanoate from Et 4-chloro-3-oxobutanoate.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Name: 6-Fluoronicotinonitrile. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination.

Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations was the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alc. adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alc. substituent (R), tetramethylammonium fluoride tert-amyl alc. (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80°C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles was demonstrated.

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Benzofuran – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 90866-33-4, is researched, Molecular C6H11ClO3, about Synthesis of optically active ethyl 4-chloro-3-hydroxybutanoate by microbial reduction, the main research direction is chlorohydroxybutanoate manufacture Candida.COA of Formula: C6H11ClO3.

Some 400 yeast strains were examined for the ability to reduce Et 4-chloroacetoacetate (COBE) to Et 4-chloro-3-hydroxybutyrate (CHBE) by using acetone-dried cells in the presence of a coenzyme-recycling system in water/n-Bu acetate. Some of the yeast strains reduced COBE to (S)-CHBE. Heating of acetone-dried cells of the selected yeast strains increased the optical purity of the product. There may be several enzymes that can reduce COBE stereo-selectively in the same yeast cells. The cultured broth of Candida magnoliae accumulated 90 g/L (S)-CHBE (96.6% enantiomeric excess, e.e.) in the presence of glucose, NADP and glucose dehydrogenase in Bu acetate. When these cells were heated, the stereoselectivity of the reduction increased to 99% e.e. (S)-CHBE is one of the useful chiral building blocks applicable to the synthesis of some pharmaceuticals.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate(SMILESS: O=C(OCC)C[C@@H](O)CCl,cas:90866-33-4) is researched.Related Products of 1762-34-1. The article 《Chiral alcohol production by NADH-dependent phenylacetaldehyde reductase coupled with in situ regeneration of NADH》 in relation to this compound, is published in European Journal of Biochemistry. Let’s take a look at the latest research on this compound (cas:90866-33-4).

Phenylacetaldehyde reductase (PAR) produced by styrene-assimilating Corynebacterium strain ST-10 was used to synthesize chiral alcs. This enzyme with a broad substrate range reduced various prochiral aromatic ketones and β-ketoesters to yield optically active secondary alcs. with an enantiomeric purity of more than 98% enantiomeric excess (e.e.). The Escherichia coli recombinant cells which expressed the par gene could efficiently produce important pharmaceutical intermediates; (R)-2-chloro-1-(3-chlorophenyl)ethanol (28 mg·mL-1) from m-chlorophenacyl chloride, Et (R)-4-chloro-(3-hydroxy butanoate) (28 mg·mL-1) from Et 4-chloro-3-oxobutanoate and (S)-N-tert-butoxycarbonyl(Boc)-3-pyrrolidinol from N-Boc-3-pyrrolidinone (51 mg·mL-1), with more than 86% yields. The high yields were due to the fact that PAR could concomitantly reproduce NADH in the presence of 3-7% (volume/volume) 2-propanol in the reaction mixture This biocatalytic process provided one of the best asym. reductions ever reported.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Category: benzofurans. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Isoquinolin-3-ol, is researched, Molecular C9H7NO, CAS is 134434-31-4, about A thermochemistry and kinetic study on the thermal decomposition of ethoxyquinoline and ethoxyisoquinoline. Author is El-Demerdash, Safinaz H.; El-Gogary, Tarek M.; El-Nahas, Ahmed M..

Quantum chem. calculations were used to study the production of ethylene and keto/enol tautomers from ethoxyquinoline (2-Equiv) and ethoxyisoquinoline (1-EisoQ and 3-EisoQ) in the gas phase and ethanol at the MP2/6-311++G(2d,2p)//BMK/6-31+G(d,p) level. The obtained data indicate that the elimination of ethylene from 1-EisoQ and 2-Equiv is slightly more favorable than from 3-EisoQ. Formation of quinolone and isoquinolone (2-EQO, 1-EisoQO, and 3-EisoQO) is kinetically favored compared to their enols. Decomposition of 2-Equiv and 1-EisoQ to ethylene and keto forms is thermodynamically and kinetically preferable more stable than the corresponding enols. However, the hydroxy form of 3-EisoQ is more stable than its keto tautomer in the gas phase and ethanol. The enol tautomers cost less energy when formed from their keto forms rather than from the parent ethoxyquinolone and ethoxyisoquinoline.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Pellegata, R.; Dosi, I.; Villa, M.; Lesma, G.; Palmisano, G. published the article 《(-)-β-Pinene as chiral promoter. 2. Stereospecific access to (-)-γ-amino-β(R)-hydroxybutyric acid (GABOB) and (R)-carnitine》. Keywords: carnitine; aminohydroxybutyric acid; pinene chiral promoter; GABOB; stereoselective preparation carnitine.They researched the compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ).COA of Formula: C6H11ClO3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:90866-33-4) here.

Treating (-)-β-pinene (I) with RCHO (R = Cl3C, EtO2C) and FeCl3 gave 60-75% the ene adducts II. A stereochem. correlation between II and their products of alk. hydrolysis is reported. Starting from II (R = Cl3C), by using a degradative sequence, a stereocontrolled approach to (R)-γ-amino-β-hydroxybutyric acid and (R)-carnitine-HCl is described.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem