Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 90866-33-4, is researched, Molecular C6H11ClO3, about Synthesis of optically active ethyl 4-chloro-3-hydroxybutanoate by microbial reduction, the main research direction is chlorohydroxybutanoate manufacture Candida.COA of Formula: C6H11ClO3.
Some 400 yeast strains were examined for the ability to reduce Et 4-chloroacetoacetate (COBE) to Et 4-chloro-3-hydroxybutyrate (CHBE) by using acetone-dried cells in the presence of a coenzyme-recycling system in water/n-Bu acetate. Some of the yeast strains reduced COBE to (S)-CHBE. Heating of acetone-dried cells of the selected yeast strains increased the optical purity of the product. There may be several enzymes that can reduce COBE stereo-selectively in the same yeast cells. The cultured broth of Candida magnoliae accumulated 90 g/L (S)-CHBE (96.6% enantiomeric excess, e.e.) in the presence of glucose, NADP and glucose dehydrogenase in Bu acetate. When these cells were heated, the stereoselectivity of the reduction increased to 99% e.e. (S)-CHBE is one of the useful chiral building blocks applicable to the synthesis of some pharmaceuticals.
I hope my short article helps more people learn about this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)COA of Formula: C6H11ClO3. Apart from the compound(90866-33-4), you can read my other articles to know other related compounds.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem