The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate(SMILESS: O=C(OCC)C[C@@H](O)CCl,cas:90866-33-4) is researched.Related Products of 1762-34-1. The article 《Chiral alcohol production by NADH-dependent phenylacetaldehyde reductase coupled with in situ regeneration of NADH》 in relation to this compound, is published in European Journal of Biochemistry. Let’s take a look at the latest research on this compound (cas:90866-33-4).
Phenylacetaldehyde reductase (PAR) produced by styrene-assimilating Corynebacterium strain ST-10 was used to synthesize chiral alcs. This enzyme with a broad substrate range reduced various prochiral aromatic ketones and β-ketoesters to yield optically active secondary alcs. with an enantiomeric purity of more than 98% enantiomeric excess (e.e.). The Escherichia coli recombinant cells which expressed the par gene could efficiently produce important pharmaceutical intermediates; (R)-2-chloro-1-(3-chlorophenyl)ethanol (28 mg·mL-1) from m-chlorophenacyl chloride, Et (R)-4-chloro-(3-hydroxy butanoate) (28 mg·mL-1) from Et 4-chloro-3-oxobutanoate and (S)-N-tert-butoxycarbonyl(Boc)-3-pyrrolidinol from N-Boc-3-pyrrolidinone (51 mg·mL-1), with more than 86% yields. The high yields were due to the fact that PAR could concomitantly reproduce NADH in the presence of 3-7% (volume/volume) 2-propanol in the reaction mixture This biocatalytic process provided one of the best asym. reductions ever reported.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem