Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 70539-42-3, is researched, SMILESS is O=C(ON1C(CCC1=O)=O)CCC(OCCOC(CCC(ON2C(CCC2=O)=O)=O)=O)=O, Molecular C18H20N2O12Journal, Journal of Molecular Catalysis B: Enzymatic called Chemical modification and immobilisation of lipase B from Candida antarctica onto mesoporous silicates, Author is Forde, Jessica; Vakurov, Alex; Gibson, Tim D.; Millner, Paul; Whelehan, Micheal; Marison, Ian W.; O’Fagain, Ciaran, the main research direction is immobilization lipase mesoporous silicate.Category: benzofurans.
The chem. modification and immobilization of lipase B from Candida antarctica (CalB) onto three different types of mesoporous silicate (MPS) were undertaken. Soluble CalB was modified by two bifunctional reagents, ethylene glycol bis(succinimidyl succinate) (EGNHS) and glutaraldehyde, and by the monofunctional citraconic anhydride. Both chem. modified and untreated enzyme were then immobilized onto SBA-15-, CNS- and MCM-type MPS by adsorption. Thermal stabilities of chem. modified CalB in solution and of the immobilized preparations were evaluated and compared. Citraconic anhydride dramatically reduced the stability of CalB whereas both bifunctionals yielded an eightfold increase in stability over the native free CalB at 70 °C. Following immobilization of the EGNHS-treated preparation onto CNS-MPS, the stability gain increased to over 60-fold and this combination proved to be the most effective stabilization strategy. CalB also showed a preference for MPS with larger pores, namely SBA-15. Immobilization of CalB in alginate beads was also stabilizing.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem