10242-10-1, 5-Chlorobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Toa solution of (3S, 3aS) -3- (aminomethyl) -8- (3-oxomorpholino) -3, 3a, 4,5-tetrahydro-1H-benzo [b] oxazolo [3, 4-d] [1, 4] oxazepin-1-one (30 mg, 0.090mmol) and 5-chlorobenzofuran-2-carboxylic acid (20 mg, 0.10 mmol) indichloromethane (10 mL) were added 4-dimethylaminopyridine (28 mg, 0.23 mmol)and 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (35 mg, 0.18mmol) . The mixture was reacted at rt for 10 hours. The reaction mixture wasconcentrated in vacuo to remove the solvent, and the residue was purified bysilica gel chromatography eluted with PE/EtOAc (V/V) 1/4 to give the titlecompound as a white solid (11 mg, 24) . The compound was characterized by thefollowing spectroscopic data: MS (ESI, pos. ion) m/z: 512.2 (M+1) and 1HNMR (400 MHz, CDCl3) : delta 7.68 (d, J 1.8 Hz, 1H) , 7.53 -7.40 (m,4H) , 7.15 (t, J 6.3 Hz, 1H) , 7.12 (d, J 2.3 Hz, 1H) , 7.02 (dd, J 8.6,2.4 Hz, 1H) , 4.55 -4.47 (m, 2H) , 4.33 (s, 2H) , 4.05 -4.00 (m, 2H) , 3.89 -3.69(m, 6H) , 2.35 -2.14 (m, 2H) ., 10242-10-1
10242-10-1 5-Chlorobenzofuran-2-carboxylic acid 937838, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZUO, Yinglin; ZHANG, Yingjun; WANG, Xiaojun; ZHANG, Jin; WEN, Liang; CHENG, Guanjun; WO2015/110024; (2015); A1;,
Benzofuran – Wikipedia
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