Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.

54008-77-4, To a solution of tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (1.0 g, 3.3 mmol), 2-bromobenzofuran (0.64 g, 3.3 mmol) and tetrakis(triphenylphosphine) palladium(0) (0.5 g, 0.4 mmol) in a mixed solution of 1,4-dioxane (20 mL) and water (2.0 mL) was added sodium carbonate (1.0 g, 7.2 mmol). The reaction mixture was stirred at 90 C. under nitrogen for 12 hours. After the reaction, it was allowed to cool to room temperature, and concentrated in vacuo, then diluted with ethyl acetate (100 mL), washed with water (100 mL). The organic phase was dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated and the residue was purified by column chromatography (silica gel, ethyl acetate/petroleum ether=1:20) to give the pure product tert-butyl 4-(benzofuran-2-yl)benzoate as a white solid (0.65 g, 67%). 1H NMR (300 MHz, CDCl3): delta 8.06 (d, J=8.7 Hz, 2H), 7.90 (d, J=8.4 Hz, 2H), 7.62-7.53 (m, 2H), 7.32-7.25 (m, 2H), 7.14 (s, 1H), 1.62 (s, 9H).

54008-77-4 2-Bromobenzofuran 2776264, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Constellation Pharmaceuticals, Inc.; Albrecht, Brian K.; Audia, James Edmund; Cook, Andrew S.; Gagnon, Alexandre; Harmange, Jean-Christophe; Nasveschuk, Christopher G.; US9206128; (2015); B2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4265-16-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of hydrazide (4, or 5 or 6) (0.2 g, 0.88 mmol) in absolute ethanol (7 mL) containing one drop of 37% hydrochloric acid, 0.88 mmol of corresponding alde-hyde derivative was added. The mixture was stirred at room temperature until TLC indicated the end of the reaction. The mixture was poured into ice and the precipitate was filtered out and dried. Flash chromatographic column was performed for purification of the final compounds, when necessary.

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Carneiro, Teiliane R.; do Amaral, Daniel N.; Fokoue, Harold H.; Sant?Anna, Carlos M. R.; Porras, Maria L. G.; Oliveira, Augusto C. A.; Cavalcanti, Bruno C.; Pessoa, Claudia; Barreiro, Eliezer J.; Lima, Lidia M.; Letters in drug design and discovery; vol. 15; 7; (2018); p. 778 – 786;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61090-37-7,2,3-Dihydrobenzofuran-4-amine,as a common compound, the synthetic route is as follows.

61090-37-7, Hydrochloric acid (9.0 g) was added dropwise to a solution of 2,3-dihydrobenzofuran-4-amine (16.3 mmol) and acetic acid (9.0 g) in acetonitrile (200 mL) at 0 C. A solution of sodium nitrite (22.0 mmol) in water (2 mL) was subsequently added and the mixture was maintained for 30 min at 0 C.Sulfur dioxide gas was passed through the reaction mixture for 2 h whereupon a solution of copper(II) chloride dihydrate (20.0 mmol) in water (3 mL) was added. Sulfur dioxide gas was passed through the reaction mixture for an additional 2 h. The reaction mixture was allowed to warm to rt and was maintained for 16 h. The reaction mixture was diluted with ice water (200 mL) and the resulting mixture was extracted with ethyl acetate (300 mL). The organic layer was washed with water (200 mL), dried (sodium sulfate), and concentrated. The residue was purified by Flash chromatography (1/70 ethyl acetate/petroleum ether) to provide 2,3-dihydrobenzofuran-4-sulfonyl chloride in 40% yield as a yellow solid. Data: 1H NMR (CDCl3) delta 7.40 (d, 1H), 7.30 (d, 1H), 7.10 (d, 1H), 4.70 (m, 2H), 3.60 (m, 2H). LC/MS (ES) m/z 283 [M+C5H11N2-C1+H]+.

As the paragraph descriping shows that 61090-37-7 is playing an increasingly important role.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2009/23844; (2009); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4265-25-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-25-2,2-Methylbenzofuran,as a common compound, the synthetic route is as follows.

A solution of 16-g (2.89 g, 21.91 mmol) dissolved in tetrahydroffiran (80 mE) was cooled to 5 C., and then N135 (4.68 g, 26.29 mmol) was slowly added thereto. The reactionsolution was reacted at normal temperature overnight, and then poured into sodium thiosulfate solution, and extracted with ethyl acetate (80 mLx3). The combined organic phase was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluted with petroleum ether) to obtain compound 16-f (2.57 g, yield 56%) as a colourless liquid. ?H NMR (400 MHz, CDC13-MeOD): oe 7.37-7.3 1 (m, 2H), 7.20-7.18 (m, 2H), 2.40 (s, 3H).

4265-25-2 2-Methylbenzofuran 20263, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; SHANGHAI YINGLI PHARMACEUTICAL CO., LTD; XU, Zusheng; (174 pag.)US2016/214994; (2016); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

65399-05-5, 5-Aminophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,65399-05-5

20 g (0.13 mol) of 5-aminoisobenzofuranone, 30 ml of 47% HBr solution was added to a 250 ml three-necked flask, and the temperature was slowly controlled at 0 C.Then slowly adding 5 ml of an aqueous solution of sodium nitrite, wherein sodium nitrite contains 10.16 g (0.14 mol), and stirring for 1 h;20.56g (0.14mol) of cuprous bromide is dissolved in 5ml of 47% hydrobromic acid solution, slowly added dropwise to the diazonium salt solution prepared above, and reacted at room temperature for 1h-3h;Filtration, washing with water and recrystallization from isopropanol gave a white powder, i.e., 5-Bromophthalide, 21.6 g, yield 76.8%.

65399-05-5 5-Aminophthalide 720669, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Changchun University Of Technology; Shi Fuqiang; Ye Peng; (5 pag.)CN108383833; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4265-25-2,4265-25-2, 2-Methylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2-METHYLFURO [3,2-c] pyridine (prepared according to the procedure by T. KITAMURA, K. Tsuda, and Y. FUJIWARA, Tetrahedron Lett. 1998,39, pp. 5375-5376) (26.0 mg, 0.195 mmol) in 2 mL of THF was treated with lithium diisopropylamide (LDA; 1.5 M in cyclohexane, 195 LL) dropwise AT-78 C. The mixture was stirred for 30 minutes (the color changed from yellow to orange-red) and was slowly treated with a solution of 1, 1, 1-TRIFLUORO-4- (5-fluoro-2-methoxyphenyl) -4-methylpentan-2-one (81.5 mg, 0.293 mmol) in 1 mL of THF. The reaction was stirred AT-78 C for 4.5 hours, quenched with 5 mL of saturated ammonium chloride solution, and diluted with 20 mL of ethyl acetate. The phases were separated and the aqueous layer was extracted with three 10 ML portions of ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated in vacuo. Flash chromatography (ethyl acetate-hexanes, 5% to 50% gradient) gave 36.0 mg (45% yield) of the title product as a clear oil.

The synthetic route of 4265-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/30213; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.

General procedure: To a solution of 2-12 in ethanol (100 mg, 0.62 mmol, 13 ml/mmol) was added the suitably functionalized benzaldehydes (0.62 mmol), followed by a solution of KOH 20% in water (0.8 ml/mmol). The solution is stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuo and diluted with distilled water. The aqueous layer was extracted with ethyl acetate and dried (Na2SO3). The organic phase was evaporated in vacuo to yield crude products which were subjected to column chromatography by using amino silica gel as adsorbent and solvent system of hexane: ethyl acetate (7:3) followed by silica gel column chromatography by using chloroform: methanol (9.5:0.5) to yield Series 2 derivatives except for 2-6 and 2-9.

15832-09-4, As the paragraph descriping shows that 15832-09-4 is playing an increasingly important role.

Reference£º
Article; Liew, Kok-Fui; Chan, Kit-Lam; Lee, Chong-Yew; European Journal of Medicinal Chemistry; vol. 94; (2015); p. 195 – 210;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128851-73-0,6-Bromobenzofuran,as a common compound, the synthetic route is as follows.

A solution of 6-bromo-l-benzofuran (50 g) in tetrahydrofuran (150 ml) was slowly added to isopropylmagnesium bromide (15% in THF, 38 g) at -25 C. After complete of addition the reaction mixture was stirred for 30 min at -25 C. Dimethylformamide (21 g) was added drop wise by maintaining temperature -25C. Reaction mass was slowly warmed at room temperature. Reaction was monitored by TLC. After completion of reaction, reaction mass was quenched by solution of ammonium chloride. Reaction mass was then extracted in toluene. Separated the toluene layer and concentrated to give l-benzofuran-6- carbaldehyde compound (30 g) in 80% yield., 128851-73-0

Big data shows that 128851-73-0 is playing an increasingly important role.

Reference£º
Patent; MANKIND PHARMA LTD.; BHAVSAR, Jigar Tarun Kumar; TIWARI, Rakesh; BHASHKAR, Bhuwan; KUMAR, Anil; (30 pag.)WO2019/73325; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57319-65-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57319-65-0,6-Aminoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

A solution of NaNO2 (2.2 g, 0.040 mol) in H2O (22 mL) was added to a mixture of 6-aminoisobenzofuran-1(3H)-one (5.0 g, 0.030 mol) in HBr (70 mL, 48%) over 5 min at 0 C. The mixture was stirred for 20 minutes before it was pipetted into an ice cold solution of CuBr (22 g, 0.21 mol) in HBr (48%, 23 mL). The resulting dark brown mixture was stirred for 20 min and was then diluted with H2O (200 mL) to produce an orange precipitate. The precipitate was filtered off, treated with sat. NaHCO3 solution, and extracted with EtOAc (20 mL*3). The organics were dried over Na2SO4 and evaporated in vacuo to give 6-bromoisobenzofuran-1(3H)-one (5.4 g, 84%). 1H NMR (300 MHz, CDCl3) delta 8.05 (d, J=1.8, 1H), 7.80 (dd, J=8.1, 1.8, 1H), 7.39 (d, J=8.1, 1H), 5.28 (s, 2H).

The synthetic route of 57319-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Vertex Pharmaceuticals Incorporated; Van Goor, Fredrick F.; Burton, William Lawrence; US2015/231142; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-41-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-41-3,Benzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a suspension of EDC¡¤HCl (2.99 g, 15.6 mmol, 1.2 equiv.) and NMM (5.72 mL, 52 mmol, 4 equiv.) in N,N-dimethylformamide (40 mL) were added successively HOBt (2.11 g, 15.6 mmol, 1.2 equiv.) and benzofuran-2-carboxylic acid 21 (2.11 g, 13 mmol, 1 equiv.). To this mixture was added a solution of N-tert-butoxycarbonylhomopiperazine 40 (2.60 g, 13 mmol, 1 equiv.) in N,N-dimethylformamide (12 mL). The reaction was allowed to stir at RT for 20 h and then diluted with water (200 mL) and extracted with ethyl acetate (3 ¡Á 200 mL). The combined organic fractions were then washed with brine, dried (Na2SO4) and concentrated under reduced pressure to give a viscous oil. Purification by column chromatography on silica gel (50:50 v/v hexanes:EtOAc) afforded the title compound 41 as a light yellow oil (3.89 g, 87%); Rf 0.33 (50:50 v/v hexanes:EtOAc); IR (ZnSe) 2974, 1685 (C=O), 1624, 1412, 1252, 1161, 926, 744, 467; 1H NMR (300 MHz, CDCl3) delta 7.65 (1H, d, J = 7.8 Hz, ArH), 7.51 (1H, d, J = 7.8 Hz, ArH), 7.34 (1H, dd, J = 7.8 Hz, J = 7.8 Hz, ArH), 7.30 (1H, br s, furan H), 7.23 (1H, dd, J = 7.8 Hz, J = 7.8 Hz, ArH), 3.93 (2H, app. br s, CH2), 3.84 (2H, app. br s, CH2), 3.63 (2H, app. br s, CH2), 3.47 (2H, app. br s, CH2), 2.04 (2H, app. br s, CH2CH2CH2), 1.47 (9H, s, 3 CH3); 13C NMR (75.5 MHz, CDCl3) delta 161.1 (C), 155.6 (C), 155.1 (C), 149.7 (C), 127.3 (C), 126.9 (aryl), 124.0 (aryl), 122.7 (aryl), 112.5 (aryl), 112.2 (furan CH), 80.3 (C(CH3)3), 50.3 (homopiperaz. CH2), 49.4 (homopiperaz. CH2), 48.6 (homopiperaz. CH2), 46.8 (homopiperaz. CH2), 28.8 (CH3), 26.5 (CH2CH2CH2); HRMS (+ESI) Calc. for C19H24N2O4 [M + Na]+ 367.1628, found: 367.1630; m/z (+ESI) 367.00 ([M + Na]+, 25%), 711.07 ([2M + Na]+, 100%).

As the paragraph descriping shows that 496-41-3 is playing an increasingly important role.

Reference£º
Article; Moussa, Iman A.; Banister, Samuel D.; Manoli, Miral; Doddareddy, Munikumar Reddy; Cui, Jinquan; MacH, Robert H.; Kassiou, Michael; Bioorganic and Medicinal Chemistry Letters; vol. 22; 17; (2012); p. 5493 – 5497;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem