New learning discoveries about 128851-73-0

Big data shows that 128851-73-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128851-73-0,6-Bromobenzofuran,as a common compound, the synthetic route is as follows.

A solution of 6-bromo-l-benzofuran (50 g) in tetrahydrofuran (150 ml) was slowly added to isopropylmagnesium bromide (15% in THF, 38 g) at -25 C. After complete of addition the reaction mixture was stirred for 30 min at -25 C. Dimethylformamide (21 g) was added drop wise by maintaining temperature -25C. Reaction mass was slowly warmed at room temperature. Reaction was monitored by TLC. After completion of reaction, reaction mass was quenched by solution of ammonium chloride. Reaction mass was then extracted in toluene. Separated the toluene layer and concentrated to give l-benzofuran-6- carbaldehyde compound (30 g) in 80% yield., 128851-73-0

Big data shows that 128851-73-0 is playing an increasingly important role.

Reference£º
Patent; MANKIND PHARMA LTD.; BHAVSAR, Jigar Tarun Kumar; TIWARI, Rakesh; BHASHKAR, Bhuwan; KUMAR, Anil; (30 pag.)WO2019/73325; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem