Tag: M.W:100-200

1914-60-9, 2,3-Dihydrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 9; 5-Iodo-2,3-dihydro-1-benzofuran-2-carboxylic acidTo a solution of the compound of Preparation 10 (39.5 g, 241.0 mmol) in acetic acid (395 ml) was added benzyltrimethylammonium dichloroiodate (125.0 g, 359.0 mmol) and zinc chloride (49.5 g, 363.0 mmol). The reaction mixture was stirred at room temperature for 40 h and then quenched with water (500 ml) and tert-butyl methyl ether (200 ml). The mixture was extracted with dichloromethane (6¡Á200 ml) and the combined extracts were washed with aqueous sodium thiosulphate solution (10%, 3¡Á250 ml) and brine (200 ml), dried (MgSO4) and concentrated in vacuo. To the residue was added cyclohexane (200 ml) and the solution was heated to reflux, before addition of tert-butyl methyl ether to solubilize the residue. The solution was cooled to 0 C. and the resulting precipitate was collected by filtration and dried in vacuo to give the title compound (44.1 g).Experimental (M-H+)- 289.0; expected 289.0

1914-60-9, As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; US2008/200540; (2008); A1;,
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87-41-2, Isobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of phthalide 1 (1 eq, 22 mmol, 3.0 g) in 30 mL ofH2SO4 (95e98%) was added dropwise at 0 C to a solution of KNO3(1.2 eq, 26.0 mmol, 2.63 g) in 12 mL of H2SO4 (95e98%). The reaction mixture was stirred at room temperature for 2h30 and then poured on ice. The resulting precipitate was filtered under reducedpressure and washed with distilled water. The filtrate was onceagain filtered under reduced pressure and the remaining solid waswashed with distilled water. The combined solids were dried under reduced pressure to give 6-nitroisobenzofuran-1(3H)-one 11(3.41 g, 87%) as an off-white solid; Rf (petroleum ether/ethyl acetate:70/30) 0.19; 1H NMR (300 MHz, CDCl3) d (ppm): 8.78 (d, J 2.1,0.7 Hz, 1H), 8.58 (dd, J 8.4, J 2.1 Hz, 1H), 7.72 (dd, J 8.4,J 0.7 Hz, 1H), 5.45 (s, 2H); HRMS (ESI): C8H5O4N [MNa],calculated 202.0111, found 202.0105. The spectral data was in accordance with the literature [24].

87-41-2, The synthetic route of 87-41-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Christine, Thifanie; Tabey, Alexis; Cornilleau, Thomas; Fouquet, Eric; Hermange, Philippe; Tetrahedron; vol. 75; 52; (2019);,
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4265-16-1, Benzo[b]furan-2-carboxaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4265-16-1

To a stirred solution of compound 2 (2.27 g, 14.30 mmol) in methanol (20 mL) at 0 C sodium borohydride (0.65 g, 17.16 mmol) was added in three portions over a period of 15 minutes, and then at room temperature for 2 h. TLC was used to monitor the reaction progress. A small amount of dilute HCl (1N) was added and the mixture was stirred for 20 min. The solvent was evaporated under vacuum and the residue was purified on silica gel column (petroleum ether:EtOAc = 5:1) to give product 3 (2.03 g, 96%) as white powder. 1H NMR (400 MHz, CDCl3): delta 7.45-7.35 (2H, m, H-4,7), 7.20-7.10 (2H, m, H-5,6), 6.46 (1H, s, H-3), 4.60 (2H,s, CH2), 4.34 (1H, br. s, OH). 13C NMR (100 MHz, CDCl3): delta 156.83 (C-7a), 155.32 (C-2), 128.34 (C-3a), 124.32 (C-6), 122.84 (C-5), 121.18 (C-4), 111.27 (C-7), 104.07 (C-3), 57.66 (CH2).

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Shi, Yi-Min; Yang, Li-Juan; Chen, Wen; Sun, Cheng-Jun; Xu, Xiao-Liang; Zhou, Shu-Ya; Zhang, Hong-Bin; Yang, Xiao-Dong; Letters in drug design and discovery; vol. 11; 8; (2014); p. 975 – 984;,
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77095-51-3, Benzofuran-6-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77095-51-3, Benzofuran-6-carboxylic acid (compound of formula VI, 2.0 gm), N,N- Dimethylformamide (20 mL) and Triethylamine (3.74 gm) were charged into a 2000 mL RBF and the mixture was cooled to 10 C. HATU (5.63 gm) was charged into the mass and stirred for 30 minutes. Added above aqueous layer containing compound of formula II at 20 C and stirred for 1 hour. 1N aqueous hydrochloric acid (100 mL) was added and stirred for 10 minutes. Gummy solid was formed. The aqueous layer was decanted. Sodium carbonate solution (100 mL) and ethylacetate (60 mL) were added to the gummy mass and stirred for 30 minutes. Layers separated and the aqueous layer was washed with ethylacetate (60 mL). The aqueous layer was acidified with 1 N aqueous hydrochloric acid (100 mL) and stirred for 30 minutes. The precipitation was faltered and the wet solid was washed with water (20 mL). The solid was dried under vacuum at 50 C for 3 hours to yield 1 .5 gm of Lifitegrast. Purity: 94.85% by HPLC.

77095-51-3 Benzofuran-6-carboxylic acid 17867234, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; DR. REDDY’S LABORATORIES LIMITED; ACHANTA, Srinivas; CHAKKA, Ramesh; DAHANUKAR, Vilas Hareshwar; CHANDRASEKHAR, Elati Ravi Rama; BHIMAVARAPU, Srinivasa Reddy; MADARABOINA, Mahendar; (35 pag.)WO2019/26014; (2019); A1;,
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23681-89-2, 2,3-Dihydrobenzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: NaH (12.0mmol) was added to a solution of 1 or 722 (1.88g, 10.0mmol) and substituted phenol (12.0mmol) in DMF (50mL) at room temperature under N2, and the mixture was stirred at 80¡ãC for 10h. Water was added to the cooled mixture, and the mixture was extracted with EtOAc several times. The combined organic layers were washed with water, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude residue was purified by silica gel column chromatography to obtain purified compound 2, or crude 2 was used directly for the next reaction without further purification., 23681-89-2

The synthetic route of 23681-89-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shinozuka, Tsuyoshi; Tsukada, Tomoharu; Fujii, Kunihiko; Tokumaru, Eri; Shimada, Kousei; Onishi, Yoshiyuki; Matsui, Yumi; Wakimoto, Satoko; Kuroha, Masanori; Ogata, Tsuneaki; Araki, Kazushi; Ohsumi, Jun; Sawamura, Ryoko; Watanabe, Nobuaki; Yamamoto, Hideki; Fujimoto, Kazunori; Tani, Yoshiro; Mori, Makoto; Tanaka, Jun; Bioorganic and Medicinal Chemistry; vol. 26; 18; (2018); p. 5099 – 5117;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

EXAMPLE 1 Synthesis of (3’R,4’S,5’R)-6″-chloro-4′-(3-chloro-2-fluorophenyl)-N-(4-((4-(2-((2-(2,6- dioxopiperidin-3-yl)-l,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)phenyl)- 2″-oxodispiro[cyclohexane-l,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamide Ste 1 : Synthesis of S 1 To a round-bottom flask, 3-hydroxyphthalic anhydride (1 g, 6.09 mmol) and 3-aminoperidine-2,6-dione hydrochloride (1.0 g, 6.09 mmol) were mixed in 50 mL of toluene. Triethyl amine (0.93 mL, 6.7 mmol) was added. The resulting reaction mixture was heated to reflux for 12 h with Dean-Stark Trap equipment. After cooling to ambient temperature, evaporation of most of the solvent to give a crude product, which was purified by flash column chromatography with DCM:EA to get the desired product as a slightly yellow solid S I (1.5g, 90% yield). 1H NMR (400 MHz, DMSO-d6) delta (ppm) 11.16 (s, 1H), 11.08 (s, 1H), 7.65 (t, = 7.6 Hz, 1H), 7.32 (d, = 7.2 Hz, 1H), 7.25 (d, = 8.4 Hz, 1H), 5.07 (dd, = 12.8 Hz, = 5.2 Hz, 1H), 2.93-2.84 (m, 1H), 2.61-2.46 (m, 1H), 2.05-2.01 (m, 1H)., 37418-88-5

37418-88-5 4-Hydroxyisobenzofuran-1,3-dione 96580, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; LI, Yangbing; AGUILAR, Angelo; ZHOU, Bing; HU, Jiantao; XU, Fuming; QIN, Chong; HU, Yang; XIANG, Weiguo; REJ, Rohan; YANG, Jiuling; HAN, Xin; BAI, Longchuan; YANG, Chao-Yie; (252 pag.)WO2017/176958; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.271-89-6,Benzofuran,as a common compound, the synthetic route is as follows.

General procedure: To a solution of anisole 3A (3.0 mmol, 324.4 mg) in THF (3.0 mL) was added n-BuLi (4.5 mmol,1.55 M in hexane, 2.87 mL) at 0 C. The mixture was stirred for 2 h at 0 C under an argon atmosphere. Then, pivalonitrile (9.0 mmol, 748.2 mg) in THF (2.0 mL) was added to the mixture at 0 C and the obtained mixture was stirred for 30 min in the temperature range of 0 C to room temperature. MeOH (2.0 mL) was added to the mixture. Then, I2 (12.0 mmol, 3045.6 mg) and K2CO3 (12.0 mmol, 1658.4 mg) were added to the mixture at room temperature, and the obtained mixture was stirred for 6 h at 70 C. Sat. aq. Na2SO3 solution (20.0 mL) was added to the reaction mixture, and the product was extracted with AcOEt (10.0 mL x 3). The organic layer was dried over Na2SO4. After filtration and removal of the solvent, the residue was purified by silica-gel column chromatography (chloroform: n-hexane 1:1) to give 2-methoxybenzonitrile 2A (315.6 mg, 79%)., 271-89-6

As the paragraph descriping shows that 271-89-6 is playing an increasingly important role.

Reference£º
Article; Uchida, Ko; Togo, Hideo; Tetrahedron; vol. 75; 39; (2019);,
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4265-25-2, 2-Methylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Methylbenzofuran (400 mg, 3.03 mmol) was dissolved in tetrahydrofuran (15 mL), cooled to -78C, and lithium diisopropylamide (2 M tetrahydrofuran solution, 1.7 mL, 3.33 mmol) was added dropwise. The reaction solution was stirred at -78C for 1 hour, and 1-bromo-3-chloropropane (525 mg, 3.33 mmol) was added and the mixture was stirred at -78C for another 2 hours. The reaction was quenched by the addition of saturated ammonium chloride solution (30 mL). The mixture was extracted with ethyl acetate (30 mL x 2). The organic phases were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure to give 2-(4-chlorobutyl)benzofuran (500 mg, as ayellow oil). MS-ESI M + H]+ calcd. 209, found 209.

4265-25-2, The synthetic route of 4265-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; WU, Lingyun; CHEN, Xiaoxin; ZHANG, Peng; LIU, Xing; ZHANG, Li; LIU, Zhuowei; CHEN, Shuhui; LONG, Chaofeng; (160 pag.)EP3299371; (2018); A1;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.28281-76-7,5-Methoxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

28281-76-7, Triphenylphosphine (1.3 g, 5.1 mmol) was dissolved in 6 ml of THF, which was cooled down to 0 C. under nitrogen gas. THF (5.0 ml) solution containing CBr4 (0.84 g, 2.5 mmol) dissolved therein was added thereto, followed by stirring until the color of the solution turned yellow. After the color change, TEA (0.91 ml, 5.1 mmol) was added drop by drop for 5 minutes, to which THF (1 ml) solution containing the compound prepared in step 4 above (0.15 g, 0.85 mmol) dissolved therein was added gradually. The reaction solution was stirred at 0 C. for 30 minutes. Then, the temperature of the reaction solution was adjusted to room temperature, followed by stirring for overnight. The reaction was quenched with a saturated NH4Cl aqueous solution. When the phases were separated, the water layer was extracted by using hexane. The combined organic layer was concentrated under reduced pressure. The obtained residue was dissolved in ethoxyethane and filtered through a celite pad. The obtained solution was concentrated by rotary evaporation and purified by flash column chromatography. As a result, a target compound was obtained (0.077 g, 27%). NMR graphs of the obtained target compound are shown in . The upper graph of is a graph showing the results of 1H NMR of Example 7, and the lower graph of is a graph showing the results of 13C NMR of Example 7. 1H NMR (DMSO-d6, 500 MHz) delta 7.91 (d, J=8.5 Hz, 1H), 7.76 (s, 1H), 7.32 (d, J=7.0 Hz, 1H), 3.93 (s, 3H). 13C NMR (DMSO-d6, 125 MHz) delta 165.0, 163.5, 145.1, 138.2, 127.9, 118.2, 117.5, 108.2, 77.4, 56.2.

As the paragraph descriping shows that 28281-76-7 is playing an increasingly important role.

Reference£º
Patent; SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION; Kim, Byeong Moon; Choi, Bong Kyu; Sim, Jae Hyun; Ryu, Eun Ju; Park, Ji Su; Bae, Il Hak; (54 pag.)US2019/345126; (2019); A1;,
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1914-60-9, 2,3-Dihydrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50)., 1914-60-9

1914-60-9 2,3-Dihydrobenzofuran-2-carboxylic acid 2776555, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
Benzofuran – Wikipedia
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