1914-60-9, 2,3-Dihydrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation 9; 5-Iodo-2,3-dihydro-1-benzofuran-2-carboxylic acidTo a solution of the compound of Preparation 10 (39.5 g, 241.0 mmol) in acetic acid (395 ml) was added benzyltrimethylammonium dichloroiodate (125.0 g, 359.0 mmol) and zinc chloride (49.5 g, 363.0 mmol). The reaction mixture was stirred at room temperature for 40 h and then quenched with water (500 ml) and tert-butyl methyl ether (200 ml). The mixture was extracted with dichloromethane (6¡Á200 ml) and the combined extracts were washed with aqueous sodium thiosulphate solution (10%, 3¡Á250 ml) and brine (200 ml), dried (MgSO4) and concentrated in vacuo. To the residue was added cyclohexane (200 ml) and the solution was heated to reflux, before addition of tert-butyl methyl ether to solubilize the residue. The solution was cooled to 0 C. and the resulting precipitate was collected by filtration and dried in vacuo to give the title compound (44.1 g).Experimental (M-H+)- 289.0; expected 289.0
1914-60-9, As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.
Reference£º
Patent; PFIZER LIMITED; US2008/200540; (2008); A1;,
Benzofuran – Wikipedia
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