77095-51-3, Benzofuran-6-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
77095-51-3, Benzofuran-6-carboxylic acid (compound of formula VI, 2.0 gm), N,N- Dimethylformamide (20 mL) and Triethylamine (3.74 gm) were charged into a 2000 mL RBF and the mixture was cooled to 10 C. HATU (5.63 gm) was charged into the mass and stirred for 30 minutes. Added above aqueous layer containing compound of formula II at 20 C and stirred for 1 hour. 1N aqueous hydrochloric acid (100 mL) was added and stirred for 10 minutes. Gummy solid was formed. The aqueous layer was decanted. Sodium carbonate solution (100 mL) and ethylacetate (60 mL) were added to the gummy mass and stirred for 30 minutes. Layers separated and the aqueous layer was washed with ethylacetate (60 mL). The aqueous layer was acidified with 1 N aqueous hydrochloric acid (100 mL) and stirred for 30 minutes. The precipitation was faltered and the wet solid was washed with water (20 mL). The solid was dried under vacuum at 50 C for 3 hours to yield 1 .5 gm of Lifitegrast. Purity: 94.85% by HPLC.
77095-51-3 Benzofuran-6-carboxylic acid 17867234, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; DR. REDDY’S LABORATORIES LIMITED; ACHANTA, Srinivas; CHAKKA, Ramesh; DAHANUKAR, Vilas Hareshwar; CHANDRASEKHAR, Elati Ravi Rama; BHIMAVARAPU, Srinivasa Reddy; MADARABOINA, Mahendar; (35 pag.)WO2019/26014; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem