4265-25-2, 2-Methylbenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2-Methylbenzofuran (400 mg, 3.03 mmol) was dissolved in tetrahydrofuran (15 mL), cooled to -78C, and lithium diisopropylamide (2 M tetrahydrofuran solution, 1.7 mL, 3.33 mmol) was added dropwise. The reaction solution was stirred at -78C for 1 hour, and 1-bromo-3-chloropropane (525 mg, 3.33 mmol) was added and the mixture was stirred at -78C for another 2 hours. The reaction was quenched by the addition of saturated ammonium chloride solution (30 mL). The mixture was extracted with ethyl acetate (30 mL x 2). The organic phases were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure to give 2-(4-chlorobutyl)benzofuran (500 mg, as ayellow oil). MS-ESI M + H]+ calcd. 209, found 209.
4265-25-2, The synthetic route of 4265-25-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; WU, Lingyun; CHEN, Xiaoxin; ZHANG, Peng; LIU, Xing; ZHANG, Li; LIU, Zhuowei; CHEN, Shuhui; LONG, Chaofeng; (160 pag.)EP3299371; (2018); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem