Derivation of elementary reaction about 90866-33-4

After consulting a lot of data, we found that this compound(90866-33-4)Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate can be used in many types of reactions. And in most cases, this compound has more advantages.

Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Systematic Investigation of Saccharomyces cerevisiae Enzymes Catalyzing Carbonyl Reductions. Author is Kaluzna, Iwona A.; Matsuda, Tomoko; Sewell, Aileen K.; Stewart, Jon D..

Eighteen key reductases from baker’s yeast (Saccharomyces cerevisiae) have been overproduced in Escherichia coli as glutathione S-transferase fusion proteins. A representative set of α- and β-keto esters was tested as substrates (11 total) for each purified fusion protein. The stereoselectivities of β-keto ester reductions depended both on the identity of the enzyme and the substrate structure, and some reductases yielded both L- and D-alcs. with high stereoselectivities. While α-keto esters were generally reduced with lower enantioselectivities, it was possible in all but one case to identify pairs of yeast reductases that delivered both alc. antipodes in optically pure form. Taken together, the results demonstrate not only that individual yeast reductases can be used to supply important chiral building blocks, but that GST-fusion proteins allow rapid identification of synthetically useful biocatalysts (along with their corresponding genes).

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Discovery of 90866-33-4

Although many compounds look similar to this compound(90866-33-4)Related Products of 90866-33-4, numerous studies have shown that this compound(SMILES:O=C(OCC)C[C@@H](O)CCl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 90866-33-4, is researched, Molecular C6H11ClO3, about Efficient production of ethyl (R)-4-chloro-3-hydroxybutanoate by a novel alcohol dehydrogenase from Lactobacillus curieae S1L19, the main research direction is Lactobacillus short chain alc dehydrogenase biotransformation ethyl chloro hydroxybutanoate; alc dehydrogenase Lactobacillus enantioselectivity production R CHBE.Related Products of 90866-33-4.

Et (R)-4-chloro-3-hydroxybutanoate ester [(R)-CHBE] is an important chiral intermediate for the synthesis of chiral drugs. In this study, a novel short-chain, NADH-dependent dehydrogenase (LCRIII) from Lactobacillus curieae S1L19 was discovered to exhibit high activity and enantioselectivity in the production of (R)-CHBE by reduction of Et 4-chloroacetoacetate (COBE). LCRIII was heterologously overexpressed in Escherichia coli and the protein was purified to homogeneity. Characterization of LCRIII showed broad substrate specificity towards a variety of ketones. In addition, an efficient cofactor regeneration system was constructed by co-expressing LCRIII and glucose dehydrogenase (GDH) in E. coli cells. Up to 1.5 M (246.8 g/L) COBE could be completely reduced to (R)-CHBE with excellent enantiomeric excess ( > 99% ee) in a monophasic aqueous system. Moreover, the process could be performed even without external addition of cofactors. These results demonstrate the great potential of this process in industrial applications.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

New learning discoveries about 90866-33-4

After consulting a lot of data, we found that this compound(90866-33-4)Synthetic Route of C6H11ClO3 can be used in many types of reactions. And in most cases, this compound has more advantages.

Yamamoto, Hiroaki; Kimoto, Norihiro; Matsuyama, Akinobu; Kobayashi, Yoshinori published the article 《Purification and properties of a carbonyl reductase useful for production of ethyl (S)-4-chloro-3-hydroxybutanoate from Kluyveromyces lactis》. Keywords: carbonyl reductase ethylchlorohydroxybutanoate Kluyveromyces.They researched the compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ).Synthetic Route of C6H11ClO3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:90866-33-4) here.

A novel carbonyl reductase (KLCR1) that reduced Et 4-chloroacetoacetate (ECAA) to synthesize Et (S)-4-chloro-3-hydroxybutanoate ((S)-ECHB) was purified from Kluyveromyces lactis. KLCR1 catalyzed the NADPH-dependent reduction of ECAA enantioselectively but not the oxidation of (S)-ECHB. From partial amino acid sequences, KLCR1 was suggested to be an α subunit of fatty acid synthase (FAS) but did not have FAS activity.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Brief introduction of 3939-12-6

After consulting a lot of data, we found that this compound(3939-12-6)Safety of 6-Fluoronicotinonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics, published in 2020-04-15, which mentions a compound: 3939-12-6, mainly applied to triazolopyridinone derivative preparation multireceptor atypical antipsychotic agent; 5-HT1A receptor; Antipsychotic; Multireceptor; Triazolopyridinone, Safety of 6-Fluoronicotinonitrile.

A series of triazolopyridinone derivatives originating from the antidepressant trazodone was designed and pharmacol. evaluated. Most of the compounds with a multireceptor functional profile exhibited high potency at the D2, 5-HT1A, and 5-HT2A receptors. Compounds 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2 H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-5-methoxy-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one and 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-3-oxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile were selected for further evaluation of druggable potential. Among these compounds, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one, as a D2 receptor partial agonist, demonstrated very potent inhibition of quipazine-induced head-twitch response, which validated its 5-HT2A receptor antagonistic efficacy in vivo. 2-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2-H)-one also demonstrated a dose-dependent effect on PCP-induced hyperactivity when administered orally. Thus, 2-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one endowed with a triazolopyridinone scaffold represents a valuable lead for the development of novel atypical antipsychotics.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Discovery of 3939-12-6

After consulting a lot of data, we found that this compound(3939-12-6)Formula: C6H3FN2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Formula: C6H3FN2. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Fluoronicotinonitrile, is researched, Molecular C6H3FN2, CAS is 3939-12-6, about Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors. Author is Yeh, Vince S. C.; Patel, Jyoti R.; Yong, Hong; Kurukulasuriya, Ravi; Fung, Steven; Monzon, Katina; Chiou, William; Wang, Jiahong; Stolarik, Deanne; Imade, Hovis; Beno, David; Brune, Michael; Jacobson, Peer; Sham, Hing; Link, J. T..

A series of metabolically stable adamantane amide 11β-HSD1 inhibitors have been synthesized and biol. evaluated. These compounds exhibit excellent HSD1 potency and HSD2 selectivity and good pharmacokinetic and pharmacodynamic profiles.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

New downstream synthetic route of 134434-31-4

After consulting a lot of data, we found that this compound(134434-31-4)Synthetic Route of C9H7NO can be used in many types of reactions. And in most cases, this compound has more advantages.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Tautomeric equilibria of heterocyclic molecules. A test of the semiempirical AM1 and MNDO-PM3 methods, published in 1991-02-28, which mentions a compound: 134434-31-4, mainly applied to tautomerism lactam lactim MO; AM1 tautomerism heterocycle; MNDO PM3 tautomerism heterocycle, Synthetic Route of C9H7NO.

Tautomeric equilibrium (mainly of the lactam-lactim type) for a rather large number of six-membered heterocyclic mols. are calculated by the semiempirical AM1, MNDO-PM3, and MNDO methods. Except for compounds with adjacent pyridine-like lone pairs both AM1 as well as MNDO-PM3 give rather reliable predictions for relative stabilities of the various tautomeric species, comparable to quite high level ab initio calculations The known Errors associated with MNDO in the treatment of heterocyclic tautomerism are thus largely corrected in AM1 as well as MNDO-PM3. For 2-hydroxypyridine-pyrid-2(1H)-one the effect of self-association is less satisfactorily described by MNDO-PM3 than by AM1. MNDO-PM3 calculated relative stabilities of methylated derivatives are, however, in considerably closer agreement with exptl. values than those obtained by AM1. Ionization potentials, especially those for lone-pair orbitals, are overestimated by all three semiempirical methods. MNDO-PM3 results for nitrogen lone-pair orbital energies are slightly better than those obtained by the AM1 or MNDO method.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Extracurricular laboratory: Synthetic route of 3939-12-6

After consulting a lot of data, we found that this compound(3939-12-6)COA of Formula: C6H3FN2 can be used in many types of reactions. And in most cases, this compound has more advantages.

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Fluoronicotinonitrile(SMILESS: N#CC1=CC=C(F)N=C1,cas:3939-12-6) is researched.Synthetic Route of CAgF3O3S. The article 《Regulating force-resistance and acid-responsiveness of pure organics with persistent phosphorescence via simple isomerization》 in relation to this compound, is published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. Let’s take a look at the latest research on this compound (cas:3939-12-6).

Stimulus-responsive purely organic room-temperature phosphorescence materials have been drawing massive attention due to their wide applications. Pyridine rings are introduced to supply π orbitals and cyanogroups are incorporated to boost the ISC efficiency by promoting the spin-forbidden transition. These groups are anticipated to enable the target mol. with multi-responsiveness because of the protonation of pyridine and their good crystallinity, which are able to regulate the acid-responsiveness and force-responsiveness, resp. Based on the above design concept, four new D-A-A’ type mols. using carbazole as the donor and the pyridine ring and cyanogroup as acceptors were designed and synthesized. The D-A-A’ structure bestows these isomers with an evident intramol. charge transfer (ICT) feature, particularly for 2-CNPyCZ and 3-CNPyCZ. All the isomers show intense long-lived phosphorescence with a lifetime over 500 ms. Particularly, 4-CNPyCZ has a high phosphorescence quantum yield of 27.1% owing to the strong intermol. interactions that stabilize the T*1 excitons. Interestingly, four isomers could retain their long-lived afterglow even after being heavily ground and the afterglow shows well resistance to external forces due to high crystallinity. 4-CNPyCZ manifests unique mechanochromism owing to the fluorescence shift and intensity change of phosphorescence. Moreover, the four isomers demonstrate distinctive acid-responsiveness and give out colorful emissions because the electron cloud dispersion of the nitrogen atom in the pyridine ring varied when altering the position of the cyanogroup. To the best of our knowledge, this is a limited work on room temperature phosphorescence about systematically regulating the responsiveness to external stimuli and proposing an effective mol. design strategy.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Discover the magic of the 3939-12-6

Although many compounds look similar to this compound(3939-12-6)Recommanded Product: 6-Fluoronicotinonitrile, numerous studies have shown that this compound(SMILES:N#CC1=CC=C(F)N=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Ferrara, Marco; Prandi, Adolfo; Randazzo, Pietro; Ronzoni, Silvano; Sinisi, Roberta; Seneci, Pierfausto; Summa, Vincenzo; Gallo, Mariana; Veneziano, Maria; Cellucci, Antonella; Mazzocchi, Nausicaa; Menegon, Andrea; Di Fabio, Romano researched the compound: 6-Fluoronicotinonitrile( cas:3939-12-6 ).Recommanded Product: 6-Fluoronicotinonitrile.They published the article 《Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS》 about this compound( cas:3939-12-6 ) in ACS Medicinal Chemistry Letters. Keywords: acid sensing ion channel inhibitor CNS. We’ll tell you more about this compound (cas:3939-12-6).

Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chem. starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound I is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Research on new synthetic routes about 90866-33-4

Compounds in my other articles are similar to this one((R)-Ethyl 4-chloro-3-hydroxybutanoate)Category: benzofurans, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate(SMILESS: O=C(OCC)C[C@@H](O)CCl,cas:90866-33-4) is researched.Synthetic Route of C18H13BCl3F4N3O. The article 《Discovery of a reductase-producing strain recombinant E. coli CCZU-A13 using colorimetric screening and its whole cell-catalyzed biosynthesis of ethyl (R)-4-chloro-3-hydroxybutanoate》 in relation to this compound, is published in Bioresource Technology. Let’s take a look at the latest research on this compound (cas:90866-33-4).

An NADH-dependent reductase (SsCR) was discovered by genome data mining. After SsCR was overexpressed in E. coli BL21, recombinant E. coli CCZU-A13 with high reductase activity and excellent stereoselectivity for the reduction of Et 4-chloro-3-oxobutanoate (COBE) into Et (R)-4-chloro-3-hydroxybutanoate ((R)-CHBE) was screened using one high-throughput colorimetric screening strategy. After the reaction optimization, a highly stereoselective bioreduction of COBE into (R)-CHBE (>99% ee) with the resting cells of E. coli CCZU-A13 was successfully demonstrated in Bu acetate-water (10:90, volume/volume) biphasic system. Biotransformation of 600 mM COBE for 8 h in the biphasic system, (R)-CHBE (>99% ee) could be obtained in the high yield of 100%. Moreover, the broad substrate specificity in the reduction of aliphatic and aromatic carbonyl compounds was also found. Significantly, E. coli CCZU-A13 shows high potential in the industrial production of (R)-CHBE (>99% ee) and its derivatives

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

New downstream synthetic route of 90866-33-4

Compounds in my other articles are similar to this one((R)-Ethyl 4-chloro-3-hydroxybutanoate)Reference of (R)-Ethyl 4-chloro-3-hydroxybutanoate, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference of (R)-Ethyl 4-chloro-3-hydroxybutanoate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about Determination of chiral pharmaceutical intermediates ethyl 4-chloro-3-hydroxybutyrate by gas chromatograph. Author is Wei, Shan-huai; Xu, Yan; Wei, Zhi-ming; Huang, Ping; Huang, Ke-run; Mu, Yun-ling; Mo, You-bin.

A gas chromatog. method for the determination of pharmaceutical intermediates chiral Et 4-chloro-3-hydroxybutyrate from Et 4-chloroacetoacetate by the asym. hydrogenation was described. Chiral capillary column and 1, 3-butanediol as internal standard were chosen as chromatog. conditions, in which all components could be separated and determined The detection limit was less than 20mg/L, the RSD was 0.42%∼0.68% and the recovery was 97.7%∼101.3%.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem