Tag: 200-300

Synthesis of pyrimidines and pyrazoles from 3-acyl-5-halobenzofurans was written by Takagi, Kaname;Ueda, Takeo. And the article was included in Chemical & Pharmaceutical Bulletin in 1975.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Pyrimidines I (R = Cl, Br, R1 = Me, Ph, R2 = NH2, Me, NHCN) were prepared by treating the benzofurans II with R2C(:NH)NH2. III (X = S) were similarly obtained with thiourea. Hydrolysis of I (R = Cl, Br, R1 = Me, R2 = NHCN) gave III (X = O), whereas I (R = Cl, Br, R1 = Ph, R2 = NHCN) gave I (R2 = NHCONH2). Reaction of II with N2H4 gave the pyrazoles IV. II were prepared by treating 5,2-R(HO)C6H3CHO with ClCH2COMe, reducing the 2-acetyl-5-halobenzofurans, and the Friedel-Crafts acylation of the 2-ethyl-5-halobenzofurans. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Improving the in vitro ethoxyresorufin-O-deethylase (EROD) assay with RTL-W1 by metabolic normalization and use of β-naphthoflavone as the reference substance was written by Heinrich, Patrick;Diehl, Ulrike;Foerster, Franziska;Braunbeck, Thomas. And the article was included in Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology in 2014.HPLC of Formula: 38183-12-9 This article mentions the following:

The ethoxyresorufin-O-deethylase (EROD) assay is a widely applied method for the evaluation of the dioxin-like activity of single substances and environmental samples. As for most enzyme assays, the specific activity is normally related to total protein contents, the determination of which has clear limitations in high-throughput assays. EROD induction potentials are usually expressed as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalent, a substance highly toxic to humans. In order to compensate for these shortcomings, two modifications of the EROD protocol are proposed: (1) EROD activity is normalized to the metabolic activity of the cells as determined by a modified thiazolyl blue tetrazolium (MTT) assay and expressed as metabolic cell equivalent (MCE) based on MTT data rather than to protein contents. Via MCE data, cytotoxicity information can always be reported in parallel to EROD data; with the protocol presented here, MTT and EROD data are collected simultaneously. (2) Among several reference substances tested (2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), β-naphthoflavone and benzo[a]pyrene), β-naphthoflavone proved to be the most suitable reference for the routine in vitro EROD assay, although TCDD has generally been preferred for purely scientific reasons. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9HPLC of Formula: 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.HPLC of Formula: 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An HPLC method for the determination of moxifloxacin in breast milk by fluorimetric detection with precolumn derivatization was written by Tekkeli, S. E. Kepekci;Gazioglu, I.;Kiziltas, M. V.. And the article was included in Acta Chromatographica in 2017.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

A new, sensitive, and selective high-performance liquid chromatog. (HPLC) method with fluorimetric detection was developed for the determination of moxifloxacin (MOX) in human breast milk. MOX was precolumn derivatized with fluorescamine; the fluorescent derivative was separated on an RP C18 column using a mobile phase composed of acetonitrile-10 mM orthophosphoric acid by isocratic elution with flow rate of 0.5 mL min^-1. The method was based on the measurement of the derivative using fluorescence detection at 481 nm with excitation at 351 nm. The calibration curve was linear over the range of 1-40 μg mL^-1. Limit of detection (LOD) and limit of quantitation (LOQ) were found to be 0.3 and 1 μg mL^-1, resp. Intra-day and interday repeatabilities were less than 3.15%. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A protective layer approach to solvatochromic sensors was written by Lee, Jung;Chang, Hyun Taek;An, Hyosung;Ahn, Sora;Shim, Jina;Kim, Jong-Man. And the article was included in Nature Communications in 2013.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

As they have been designed to undergo colorimetric changes that are dependent on the polarity of solvents, the majority of conventional solvatochromic mol. based sensor systems inevitably display broad overlaps in their absorption and emission bands. As a result, colorimetric differentiation of solvents of similar polarity has been extremely difficult. Here we present a tailor-made colorimetric and fluorescence turn-on type solvatochromic sensor that enables facile identification of a specific solvent. The sensor system displays a colorimetric transition only when a thin protective layer, which protects the solvatochromic materials, is destroyed or disrupted by a specific solvent. The versatility of the strategy is demonstrated by designing a sensor that differentiates chloroform and dichloromethane colorimetrically and one that performs sequence selective colorimetric sensing. In addition, the approach is employed to construct a solvatochromic mol. AND logic gate. The new strategy could open new avenues for the development of novel solvatochromic sensors. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Safety of 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In-capillary derivatization with fluorescamine for the rapid determination of adamantane drugs by capillary electrophoresis with UV detection was written by Prapatpong, Pornpan;Nuchtavorn, Nantana;Macka, Mirek;Suntornsuk, Leena. And the article was included in Journal of Separation Science in 2018.Synthetic Route of C17H10O4 This article mentions the following:

In-capillary derivatization using fluorescamine as the labeling reagent was proposed to enhance the detectability of adamantine drugs (memantine, amantadine, rimantadine) by spectrophotometric detection. Fluorescamine and the drugs were delivered to the capillary electrophoresis instrument at a ratio of 10:1 by zone injection. The derivatization reaction occurred following the application of voltage (20 kV). The derivatized products, hydrolyzed- fluorescamine and excess fluorescamine were separated in 7 min using 100 mM borate buffer (pH 10.0) containing 0.1% w/v of Brij-35 and 20% volume/volume of acetonitrile. Validation data showed good linearity (r² > 0.98), precision (%RSDs < 3.4), and accuracy (recoveries ranging from 98.0 to 102.0%). The detection and quantitation limits were in the range of 6.0-8.5 and 18-25 μM, resp. The validation data were comparable to reported methods, however, the current method offers better precision with enhanced sensitivity (up to six times). Applications of the method show percent labeled amounts found in the studied samples within 100.6-109.3%, which complied with the USP limit (90.0-110.0%). The method was simple, rapid and automated, and requires no extra instrumentation or skillful operators. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Synthetic Route of C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Synthetic Route of C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles was written by Cui, Mingyue;Wiraja, Christian;Qi, Lim Wei;Ting, Sharon Chew Wan;Jana, Deblin;Zheng, Mengjia;Hu, Xiao;Xu, Chenjie. And the article was included in Nano Research in 2020.Formula: C17H10O4 This article mentions the following:

Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility, controllable morphol. and so on. They can be used both as the drug carrier and imaging vehicle. Here, an aminated ultra-small silica nanoparticle based system is developed with various functionalities. Multiple mols. including fluorophore, folic acid, and antibody are coupled to this system to achieve specific applications such as bacterial/cell labeling and recognition. [graphic not available: see fulltext]. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Visualization procedures for proteins and peptides on flat-bed monoliths and their effects on matrix-assisted laser-desorption/ionization time-of-flight mass spectrometric detection was written by Wouters, Bert;Vanhoutte, Dominique J. D.;Aarnoutse, Petra;Visser, Adriaan;Stassen, Catherine;Devreese, Bart;Kok, Wim Th.;Schoenmakers, Peter J.;Eeltink, Sebastiaan. And the article was included in Journal of Chromatography A in 2013.Related Products of 38183-12-9 This article mentions the following:

The present study concerns the application of visualization methods, i.e. coomassie-brilliant-blue-R staining (CBB-R), silver-nitrate staining, and fluorescamine labeling, and subsequent MALDI-MS anal. of intact proteins and peptides on the surface of flat-bed monoliths, intended for spatial two-dimensional chromatog. separations The use of 100-μm thick macroporous poly(Bu methacrylate-co-ethylene dimethacrylate) flat-bed monoliths renders a fixation step obsolete, so that CBB-R and silver-nitrate staining and destaining could be achieved in 10-15 min as opposed to up to 24 h, as is typical on 2D-PAGE gels. The detection limits remained comparable. The compatibility of the monolithic layer with subsequent MALDI-MS anal. of individual proteins and peptide spots was investigated with regards to mass accuracy, mass precision, resolution, and signal intensity. When comparing results from MALDI-MS anal. of proteins and peptides on a flat-bed monolith to results obtained directly on stainless-steel target plates, significant losses in mass precision, signal intensity, and an increased variation in resolution were observed In addition, a loss in signal intensity up to two orders of magnitude was observed when using monolithic layers. After CCB-R and silver-nitrate staining and destaining to disrupt the protein-dye complexes no MALDI spectra with significant S/N ratios could be achieved. After fluorescamine labeling heterogeneous signals were observed, which resulted from a distribution in the number of fluorescence-labeled lysine groups and from the presence of labeled derivatives that had undergone condensation reactions. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Related Products of 38183-12-9).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 38183-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Covalent cross-links in polyampholytic chitosan fibers enhances bone regeneration in a rabbit model was written by Ghosh, Paulomi;Rameshbabu, Arun Prabhu;Das, Dipankar;Francis, Nimmy K.;Pawar, Harpreet Singh;Subramanian, Bhuvaneshwaran;Pal, Sagar;Dhara, Santanu. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2015.Formula: C17H10O4 This article mentions the following:

Chitosan fibers were prepared in citric acid bath, pH 7.4 and NaOH solution at pH 13, to form ionotropically cross-linked and uncross-linked fibers, resp. The fibers formed in citric acid bath were further cross-linked via carbodiimide chem.; wherein the pendant carboxyl moieties of citric acid were used for new amide bond formation. Moreover, upon covalent crosslinking in the ionically gelled citrate-chitosan fibers, incomplete conversion of the ion pairs to amide linkages took place resulting in the formation of a dual network structure. The dual cross-linked fibers displayed improved mech. property, higher stability against enzymic degradation, hydrophobicity and superior bio-mineralization compared to the uncross-linked and native citrate cross-linked fibers. Addnl., upon cyclic loading, the ion pairs in the dual cross-linked fibers dissociated by dissipating energy and reformed during the relaxation period. The twin property of elasticity and energy dissipation mechanism makes the dual cross-linked fiber unique under dynamic mech. conditions. The differences in the physico-chem. characteristics were reflected in protein adsorption, which in turn influenced the cellular activities on the fibers. Compared to the uncross-linked and ionotropically cross-linked fibers, the dual cross-linked fibers demonstrated higher proliferation and osteogenic differentiation of the MSCs in vitro as well as better osseous tissue regeneration in a rabbit model. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile access to biaryls and 2-acetyl-5-arylbenzofurans via Suzuki coupling in water under thermal and microwave conditions was written by Darweesh, Ahmed F.;Shaaban, Mohamed R.;Farag, Ahmad M.;Metz, Peter;Dawood, Kamal M.. And the article was included in Synthesis in 2010.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Phosphine-free Suzuki-Miyaura C-C cross-coupling reactions of activated and deactivated aryl halides and 2-acetyl-5-bromobenzofuran with various aryl- or heteroarylboronic acids were investigated. A benzothiazole-based Pd(II) complex was used as a pre-catalyst for the reactions under both thermal and microwave conditions in air using water as a solvent. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization and biological activities of some new azetidin-2-ones and thiazolidin-4-ones bearing benzofuran moiety was written by Tiriapur, Vijay Kumar;Basawaraj, Raga. And the article was included in Indian Journal of Heterocyclic Chemistry in 2012.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

1-(5-Bromo-1-benzofuran-2-yl)ethanone hydrazone (I) was obtained by condensation of 5-bromo-2-acetylbenzofuran with NH₂NH₂. The compound I on treatment with substituted aldehydes in presence of ethanol gave azine compounds The reaction of these azine compounds with chloroacetyl chloride and few drops of Et₃N in presence of dry benzene afforded the corresponding 1-{[1-(5-bromo-1-benzofuran-2-yl)ethylidene]amino}-3-chloro-4-(substituted phenyl)azetidine-2-ones. The treatment of the azine compounds with mercaptoacetic acid in presence of DMF furnished 3-{[1-(5-bromo-1-benzofuran-2-yl)ethylidene]amino}-2-(substituted phenyl)-1,3-thiazolidine-4-ones, resp. All newly synthesized compounds were characterized on the basis of IR, ¹H NMR and mass spectral data and screened for their antitubercular, antibacterial, and antifungal activities. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem