Category: benzofurans

Synthetic Route of 763114-25-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.763114-25-6, Name is 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile, molecular formula is C16H8FNO2. In a Article，once mentioned of 763114-25-6

An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4011O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 5-Bromobenzofuran-3(2H)-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 54450-20-3

An organocatalytic asymmetric formal aza-[3+3]cycloaddition of readily available N-Tosyl-3-aminobenzofuran with alpha,beta-unsaturated aldehydes was developed for the first time. This method enables the facile synthesis of biologically active and synthetically challenging polysubstituted fused benzofuran derivatives bearing two stereocenters in high yields with excellent diastereo-, and enantioselectivity (up to >20 : 1 dr, and >99% ee). (Figure presented.).

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3605O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 2-Methylbenzofuran, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4265-25-2, Name is 2-Methylbenzofuran, molecular formula is C9H8O

The intramolecular nucleophilic addition of 2-allylphenol was catalyzed by RuCl3·nH2O/AgOTf-PPh3-Cu(OTf) 2 to afford 2,3-dihydro-2-methylbenzofuran in good yield, while 2-(3-butenyl)-phenol was converted to 3,4-dihydro-2(2H)-methylbenzopyran.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H140O – PubChem

Application of 4265-16-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 4265-16-1, Benzo[b]furan-2-carboxaldehyde, introducing its new discovery.

Three mononuclear copper complexes [Cu(PDTP)Cl2] (PDTP = 4-phenyl-2,6-di(thiazole-2-yl)pyridine, CuPDTP), [Cu(ADTP)Cl2] (ADTP = 4-(anthracen-9-yl)-2,6-di(thiazole-2-yl)pyridine, CuADTP) and [Cu(BFDTP)Cl2] (BFDTP = 4-(benzofuran-2-yl)-2,6-di(thiazole-2-yl) pyridine, CuBFDTP) were synthesized and characterized. The X-ray single crystallography results indicated that the Cu(ii) ions showed slightly distorted square pyramid coordination environments, and the ligands deviated from ideal planarity in all three compounds. Based on the DNA binding studies, it was demonstrated that these three complexes exhibited weak DNA binding strengths, which were most likely groove binding modes. CuPDTP, CuADTP and CuBFDTP induced efficient DNA cleavage in the dark without the addition of external catalysts (oxidant or reductant). In contrast, in the presence of reducing or oxidizing agents, the nuclease activities increased more than 10-fold. Mechanistic investigations revealed the participation of reactive oxygen species, which can be trapped by ROS radical scavengers and ROS sensors. In the same experimental conditions, the free ligands and CuCl2 did not display any DNA cleaving activity. This result indicates that the complexes, rather than their components, play a significant role in the nuclease reaction process and that DNA cleavage may be initiated in an oxidative pattern. The proposed mechanism was attributed to the in situ activation of molecular oxygen by the oxidation of the copper complexes. In the MTT cytotoxicity studies, the three Cu(ii) complexes exhibited an antitumor activity against the HeLa, BEL-7402 and HepG2 tumor cell lines. The HeLa cells treated with Cu(ii) complexes demonstrated marked changes in their nuclear morphology, which were detected by Hoechst 33258 nuclear staining and acridine orange/ethidium bromide (AO/EB) staining assays. Nuclear chromatin cleavage also was observed from alkaline single-cell gel electrophoresis (comet assay).

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H923O – PubChem

Related Products of 64175-51-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.64175-51-5, Name is 2-(Benzofuran-3-yl)acetic acid, molecular formula is C10H8O3. In a Article，once mentioned of 64175-51-5

FFA2, also called GPR43, is a G-protein coupled receptor for short chain fatty acids which is involved in the mediation of inflammatory responses. A class of azetidines was developed as potent FFA2 antagonists. Multiparametric optimization of early hits with moderate potency and suboptimal ADME properties led to the identification of several compounds with nanomolar potency on the receptor combined with excellent pharmacokinetic (PK) parameters. The most advanced compound, 4-[[(R)-1-(benzo[b]thiophene-3-carbonyl)-2-methyl-azetidine-2-carbonyl]-(3-chloro-benzyl)-amino]-butyric acid 99 (GLPG0974), is able to inhibit acetate-induced neutrophil migration strongly in vitro and demonstrated ability to inhibit a neutrophil-based pharmacodynamic (PD) marker, CD11b activation-specific epitope [AE], in a human whole blood assay. All together, these data supported the progression of 99 toward next phases, becoming the first FFA2 antagonist to reach the clinic.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2678O – PubChem

1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, belongs to benzofurans compound, is a common compound. Application In Synthesis of 2,2-Dimethyl-2,3-dihydrobenzofuran-7-olIn an article, once mentioned the new application about 1563-38-8.

Abstract: Carbofuran residue in vegetables is a concern to human health. Direct competitive enzyme-linked immunosorbent assay (dcELISA) and dipstick immunoassay were developed in the present study. The dcELISA showed a 50% inhibition concentration (IC50) and working range of 1.3 and 0.2 to 7.5 ng/mL, respectively, while the cutoff value of dipstick immunoassay was 20 ng/mL. Applying the two immunoassays, we achieved the goal of rapid screening of carbofuran residue in commercial vegetables with a simple sample processing method. Among 46 leek, 39 potato, and 39 sweet potato samples, carbofuran residue was detected in 22% of the leek samples, and two samples exceeded the maximum residue limit of China (0.02 mg/kg). In addition, carbofuran residue was found at less than 2.5 ng/g in one potato and one sweet potato samples. The residual level of carbofuran measured by immunoassays agreed well with those determined by ultra-performance liquid chromatography tandem mass spectrometry. To ensure food safety and human health, it is greatly necessary and meaningful to monitor carbofuran residue in commercial vegetables. Practical Application: Rapid monitoring of carbofuran residue in vegetables is very necessary and important for consumers, regulatory agencies, and food industry.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2437O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 16859-59-9, name is 3-Hydroxyisobenzofuran-1(3H)-one, introducing its new discovery. Safety of 3-Hydroxyisobenzofuran-1(3H)-one

The title compounds gave carbocations in acid media.The electrophilic aromatic substitution of those carbocations was studied.

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Benzofuran – Wikipedia,
Benzofuran | C8H1439O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 3-Aminobenzofuran-2-carboxamide, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 54802-10-7, name is 3-Aminobenzofuran-2-carboxamide. In an article，Which mentioned a new discovery about 54802-10-7

A series of new 3-(glycinamido)-benzofuran-2-carboxamide and 3-(beta-alanamido)-benzofuran-2-carboxamide derivatives (5a?o) were synthesized for the purpose of developing the new bioactive chemical entities and evaluated for their in vitro antimicrobial, anti-inflammatory and DPPH radical scavenging activities. The synthesized compounds were characterized by NMR, IR, Mass and X-ray crystallographic techniques.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2828O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C28H30O4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 125-20-2, Name is Thymolphthalein, molecular formula is C28H30O4

Hyperthermostable alkaline lipase from Bacillus sonorensis 4R was purified and characterized. The enzyme production was carried out at 80C and 9.0 pH in glucose-tween inorganic salt broth under static conditions for 96 h. Lipase was purified by anion exchange chromatography by 12.15 fold with a yield of 1.98%. The molecular weight of lipase was found to be 21.87 KDa by SDS-PAGE. The enzyme activity was optimal at 80C with t 1 / 2 of 150 min and at 90C, 100C, 110C, and 120C; the respective values were 121.59 min, 90.01 min, 70.01 min, and 50 min. The enzyme was highly activated by Mg and t 1 / 2 values at 80C were increased from 150 min to 180 min when magnesium and mannitol were added in combination. The activation energy calculated from Arrhenius plot was 31.102 KJ/mol. At 80-120C, values of Delta H and Delta G were in the range of 28.16-27.83 KJ/mol and 102.79 KJ/mol to 111.66 KJ/mol, respectively. Lipase activity was highest at 9.0 pH and stable for 2 hours at this pH at 80C. Pretreatment of lipase with MgSOand CaSOstimulated enzyme activity by 249.94% and 30.2%, respectively. The enzyme activity was greatly reduced by CoCl CdCl HgCl CuCl Pb(NO PMSF, orlistat, oleic acid, iodine, EDTA, and urea.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4270O – PubChem

Electric Literature of 54008-77-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 54008-77-4, 2-Bromobenzofuran, introducing its new discovery.

Halodeboronation of organotrifluoroborates using commercially available tetrabutylammonium tribromide (TBATB) or cesium triiodide in aqueous medium is reported. The mild, transition metal-free method has proven to be tolerant of a wide range of functional groups. High regio- and chemoselectivity are observed. Two synthetic routes to (Z)-dibromoalkenes from alkynes, through stereodefined (Z)-2-bromoalkenyltrifluoroborates and (Z)-1,2-bis(boryl) alkenyltrifluoroborates, have been developed using the TBATB mediated bromodeboronation as the key step.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3268O – PubChem