Category: benzofurans

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ) is researched.COA of Formula: C6H11ClO3.Chung, Sunho; Hwang, Yunesahng published the article 《Stereoselective hydrolysis of racemic ethyl 4-chloro-3-hydroxybutyrate by a lipase》 about this compound( cas:90866-33-4 ) in Biocatalysis and Biotransformation. Keywords: lipase stereoselective hydrolysis ethyl chlorohydroxybutyrate. Let’s learn more about this compound (cas:90866-33-4).

The stereoselective hydrolysis of racemic Et 4-chloro-3-hydroxybutyrate (ECHB) was performed by using Novozym 435 lipase in an aqueous phase. It was found that racemic ECHB was hydrolyzed to (R)-ECHB and (S)-3-hydroxy-gamma-butyrolactone (HGBL) via (S)-4-chloro-3-hydroxybutyric acid. From this result, (R)-ECHB (99%ee) was produced in a good yield on a preparative scale.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 70539-42-3, is researched, Molecular C18H20N2O12, about The two coiled coils in the isolated rod domain of the intermediate filament protein desmin are staggered. A hydrodynamic analysis of tetramers and dimers, the main research direction is desmin quaternary structure.Safety of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Desmin protofilaments and the proteolytically derived α-helical rod domain have been characterized by high-resolution gel permeation chromatog. (GPC) using columns calibrated for the determination of viscosity radii. Addnl. characterization by chem. crosslinking and the determination of sedimentation values allowed the calculation of the mol. dimensions of the mol. species isolated. In dilute buffers GPC separated desmin rod preparations into 2 complexes: a dimer species (single coiled coil) with a length of 50 nm and a tetramer species (2 coiled coils) with a length of 65 nm. Thus the 2 coiled coils in the tetramer are staggered by ∼15 nm. The hydrodynamically derived lengths of the rod dimer and tetramer are supported by electron microscopy after metal shadowing. The hydrodynamic properties of desmin protofilaments follow that of the rod tetramer. The present results explain the inhomogeneity of mols. encountered in previous electron microscopical analyses.

The article 《The two coiled coils in the isolated rod domain of the intermediate filament protein desmin are staggered. A hydrodynamic analysis of tetramers and dimers》 also mentions many details about this compound(70539-42-3)Safety of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, you can pay attention to it, because details determine success or failure

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Di Perri, T.; Auteri, A. published an article about the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0,SMILESS:O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+] ).Product Details of 129-18-0. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:129-18-0) through the article.

Lysine acetylsalicylate (I) [37933-78-1], flufenamic acid [530-78-9], mefenamic acid [61-68-7], indomethacin [53-86-1], and Na phenylbutazone [129-18-0] had anticomplementary activity in vitro. I inhibited the activation of C1, whereas flufenamic and mefenamic acids inhibited the activation of C3. Indomethacin inhibited C2, C3, and C4, while phenylbutazone inhibited C3 and C4. These drugs were also anticomplementary in vivo.

The article 《Anticomplementary action of some nonsteroidal antiinflammatory drugs》 also mentions many details about this compound(129-18-0)Product Details of 129-18-0, you can pay attention to it, because details determine success or failure

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Argpyrimidine-tagged rutin-encapsulated biocompatible (ethylene glycol dimers) nanoparticles: Application for targeted drug delivery in experimental diabetes (Part 2), the main research direction is argpyrimidine rutin ethylene glycol nanoparticle diabetes; Advanced glycation end products; Argpyrimidine; Diabetes mellitus; Nanoparticles; Rutin; Targeted drug delivery.Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Diabetes mellitus is characterized by hyperglycemia and associated complications. However, long-term diabetes control is not often sustained by currently available therapeutic approaches. Research on nanoparticle-mediated drug delivery systems is in progress. Here we have tested a ligand (argpyrimidine)-tagged drug (rutin)-encapsulated biocompatible (ethylene glycol dimers) nanoparticle for targeted drug delivery in streptozotocin-induced diabetic rats. Argpyrimidine, being an advanced glycation end product (AGE), directs the nanoparticles to interact with cell surface receptors of AGEs (RAGE) and delivers the drug into the cells. The bioflavonoid rutin possesses antihyperglycemic property, and has been used for nanocapsulation. Two doses of nanoparticles containing 20 mg rutin/kg body weight were administered (i.v. at 7 days interval) into streptozotocin-induced diabetic rats. Compared to free rutin, nanoparticle treatment appears to be significantly more effective in controlling the diabetogenic effects – hyperglycemia, hyperlipidemia, oxidative stress, etc, including heart-associated complications. This approach may thus be explored for drug delivery in the treatment of diabetes mellitus.

The article 《Argpyrimidine-tagged rutin-encapsulated biocompatible (ethylene glycol dimers) nanoparticles: Application for targeted drug delivery in experimental diabetes (Part 2)》 also mentions many details about this compound(70539-42-3)Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, you can pay attention to it or contacet with the author([email protected]) to get more information.

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Computed Properties of C19H19N2NaO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Synthesis of certain new 3,5-dioxopyrazolidines of pharmacological interest. Author is Abou-Gharbia, M.; El Zanfally, S.; Khalifa, M..

Pyrazolidinediones I [R = R1 = 5-nitro-2-pyridyl (Q), R2 = R3 = Et, Pr, Bu; R = Q, Ph, R1 = Ph, R2 = Q, R3 = Bu; R = Q, R1 = Ph, R2 = R3 = Et] were obtained in 60-73% yield by treating Na derivatives of appropriately substituted pyrazolidinediones with QCl.

The article 《Synthesis of certain new 3,5-dioxopyrazolidines of pharmacological interest》 also mentions many details about this compound(129-18-0)Computed Properties of C19H19N2NaO2, you can pay attention to it, because details determine success or failure

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Pharmacology of antiinflammatory imidazoles. Author is Winter, R..

Of 67 imidazole derivatives tested for antinflammatory activity in rats, 2,5-dimethyl-4-phenylimidazole-HCl (I) [40405-82-1] was the most active. Its antiedema and granulation inhibiting actions were greater than those of phenylbutazone sodium [129-18-0]. On further testing I potentiated hexobarbital narcosis in mice, had anticonvulsive activity in mice, and decreased the body temperature of rats. It did not have a central analgetic effect. The acute LD50 values for I were 71 mg/kg i.p. and 230 mg/kg orally in mice and 76.5 mg/kg s.c. in rats.

The article 《Pharmacology of antiinflammatory imidazoles》 also mentions many details about this compound(129-18-0)Quality Control of Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, you can pay attention to it, because details determine success or failure

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Category: benzofurans. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about [Effect of] prostaglandins and prostaglandin antagonists on bovine pulmonary vein in vitro. Author is Burka, J. F.; Eyre, P..

Sodium meclofenamate [6385-02-0] and phloretin phosphates dimer blocked PGE2 (I) [363-24-6]-induced contractions of bovine pulmonary vein whereas relaxations were not blocked. Diethylcarbamazine citrate [1642-54-2] inhibited the relaxant effect of I but it also antagonized the contractile effects of histamine, 5-hydroxytryptamine, and PGF2α [551-11-1] so its action was rather nonspecific. Phenylbutazone Na [129-18-0] antagonized the contractile and relaxant actions of I and the contractile actions of PGF2α. By classifying receptors by antagonism, the bovine pulmonary vein appears to contain I phenylbutazone-type, I Na meclofenamate-type, I phloretin phosphate -type, and PGF2α phenylbutazone-type receptors.

The article 《[Effect of] prostaglandins and prostaglandin antagonists on bovine pulmonary vein in vitro》 also mentions many details about this compound(129-18-0)Category: benzofurans, you can pay attention to it, because details determine success or failure

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives, published in 2019-02-28, which mentions a compound: 3939-12-6, Name is 6-Fluoronicotinonitrile, Molecular C6H3FN2, SDS of cas: 3939-12-6.

A series of nitrobenzamide derivatives containing N-benzyl or N-pyridinylmethyl moieties I [R = H, 5-CF3, 5-F, etc.; R1 = F, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl, etc.; X = Y = CH; X = CH, Y = N; X = N, Y = CH] was designed and synthesized as new anti-tubercular agents. Many of synthesized compounds I exhibited potent in vitro antitubercular activity. Four compounds I [R = 5-NO2; R1 = 4-MeO, 4-(trifluoromethyl)-1-piperidyl, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl] had not only the same excellent MIC values against both drug-sensitive MTB strain H37Rv and two drug-resistant clin. isolates as PBTZ169 and the lead I [R = 5-NO2; R1 = 4-(trifluoromethyl)-1-piperidyl; X = Y = CH], but also acceptable safety indexes.

The article 《Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives》 also mentions many details about this compound(3939-12-6)SDS of cas: 3939-12-6, you can pay attention to it, because details determine success or failure

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide, is researched, Molecular C19H19N2NaO2, CAS is 129-18-0, about Antagonistic effects of phalloidin, α-amanitin and extracts of Amanita phalloides, the main research direction is amanitin poisoning prevention; phalloidin poisoning prevention; penicillin amanitin toxicity; sulfonamide amanitin toxicity; phenylbutazone amanitin toxicity; chloramphenicol amanitin toxicity.Recommanded Product: 129-18-0.

The hepatotoxicity of α-amanitin [23109-05-9] may be decreased by drugs which displace it from serum binding sites. Swiss mice were protected from i.p. lethal doses of phaloidin [17466-45-4] by phenylbutazone Na (I Na) [129-18-0] and rifampicin (II) [13292-46-1]. I, II, sulfadimethoxine Na [1037-50-9], or Bactrim, a mixture of sulfamethoxazole [723-46-6] and trimethoprim [738-70-5], were also prophylactically active against poisoning by an extract prepared from the whole mushroom (Amanita phalloides). Penicillin G [61-33-6] and I also showed curative effects against the extract in MAG mice. Protection against α-amanitin was provided in Swiss mice by I, aminopyrine [58-15-1], penicillin, chloramphenicol Na succinate [982-57-0], sulfadimethoxine, or Bactrim. Combined treatment, including especially Bactrim, penicillin and chloramphenicol, gave greater protection.

The article 《Antagonistic effects of phalloidin, α-amanitin and extracts of Amanita phalloides》 also mentions many details about this compound(129-18-0)Recommanded Product: 129-18-0, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 129-18-0, is researched, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2Journal, Article, Nature (London), New Biology called Enzyme release from guinea pig polymorphonuclear leukocyte lysosomes inhibited in vitro by antiinflammatory drugs, Author is Ignarro, Louis J.; Colombo, Carmelo, the main research direction is antiinflammatory drug lysosome enzyme release; aryl sulfatase release antiinflammatory drug; glucuronidase release antiinflammatory drug; galactosidase release antiinflammatory drug.Related Products of 129-18-0.

Chloroquine phosphate [50-63-5], hydrocortisone phosphate [3863-59-0], phenylbutazone [50-33-9] oxyphenbutazone [129-20-4], acetylsalicylic acid [50-78-2], indomethacin [53-86-1], and flufenamic acid [530-78-9] inhibited the release of aryl sulfatase [9016-17-5] from a guinea pig polymorphonuclear leukocyte granule suspension incubated in hypotonic sucrose-Tris buffer at neutral pH and 37.deg.. The Na salts of phenylbutazone, acetylsalicylic acid, and indomethacin were more active than their resp. free acids. Most of the acidic drugs gave slightly lower vlaues of inhibition of enzyme release at 10-5 M than at 10-l M. The antiinflammatory drugs also inhibited release of β-glucuronidase [9001-45-0] and β-galactosidase [9031-11-2] from the leukocyte granules. In this case, the biphasic action of acidic drugs was observed only at concentrations .geq.10-4M.

The article 《Enzyme release from guinea pig polymorphonuclear leukocyte lysosomes inhibited in vitro by antiinflammatory drugs》 also mentions many details about this compound(129-18-0)Related Products of 129-18-0, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem