Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 70539-42-3, is researched, Molecular C18H20N2O12, about The two coiled coils in the isolated rod domain of the intermediate filament protein desmin are staggered. A hydrodynamic analysis of tetramers and dimers, the main research direction is desmin quaternary structure.Safety of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.
Desmin protofilaments and the proteolytically derived α-helical rod domain have been characterized by high-resolution gel permeation chromatog. (GPC) using columns calibrated for the determination of viscosity radii. Addnl. characterization by chem. crosslinking and the determination of sedimentation values allowed the calculation of the mol. dimensions of the mol. species isolated. In dilute buffers GPC separated desmin rod preparations into 2 complexes: a dimer species (single coiled coil) with a length of 50 nm and a tetramer species (2 coiled coils) with a length of 65 nm. Thus the 2 coiled coils in the tetramer are staggered by ∼15 nm. The hydrodynamically derived lengths of the rod dimer and tetramer are supported by electron microscopy after metal shadowing. The hydrodynamic properties of desmin protofilaments follow that of the rod tetramer. The present results explain the inhomogeneity of mols. encountered in previous electron microscopical analyses.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem