The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4 ) is researched.COA of Formula: C6H11ClO3.Chung, Sunho; Hwang, Yunesahng published the article 《Stereoselective hydrolysis of racemic ethyl 4-chloro-3-hydroxybutyrate by a lipase》 about this compound( cas:90866-33-4 ) in Biocatalysis and Biotransformation. Keywords: lipase stereoselective hydrolysis ethyl chlorohydroxybutyrate. Let’s learn more about this compound (cas:90866-33-4).
The stereoselective hydrolysis of racemic Et 4-chloro-3-hydroxybutyrate (ECHB) was performed by using Novozym 435 lipase in an aqueous phase. It was found that racemic ECHB was hydrolyzed to (R)-ECHB and (S)-3-hydroxy-gamma-butyrolactone (HGBL) via (S)-4-chloro-3-hydroxybutyric acid. From this result, (R)-ECHB (99%ee) was produced in a good yield on a preparative scale.
The article 《Stereoselective hydrolysis of racemic ethyl 4-chloro-3-hydroxybutyrate by a lipase》 also mentions many details about this compound(90866-33-4)COA of Formula: C6H11ClO3, you can pay attention to it, because details determine success or failure
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem