Category: benzofurans

Von Bruchhausen, V.; Lohmann, H.; Osvath, J. published the article 《The pharmacokinetic profile of pyrazinobutazone in man》. Keywords: pyrazinobutazone formulation pharmacokinetics.They researched the compound: Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide( cas:129-18-0 ).SDS of cas: 129-18-0. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:129-18-0) here.

The rate of absorption of phenylbutazone (I) [50-33-9] from pyrazinobutazone [4985-25-5] capsules was lower than that from I capsules. The capsules were bioequivalent to an equimolar dose of Na phenylbutazone [129-18-0] in solution, as judged by both the area under the plasma level curves and the sum of the unchanged I excreted in the urine. A single dose of 300 mg pyrazinobutazone produced maximum plasma levels of 35.2 μg/mL at 5.5 h after administration. Two dosage schedules for long-term therapy were tested (2400 and 1500 mg/wk). Both produced accumulation to saturation plasma levels within approx. 3 days. The concentration of I obtained with the lower dosage was about 110 μg/mL plasma. This corresponded with the recommendations for long-term therapy with I. With the higher dosage, the plasma levels were elevated by only 25%, however, the renal elimination of unchanged drug and the number of side-effects were remarkably increased. The recommended dosage scheme is specifically adapted to the pharmacokinetics of pyrazinobutazone.

Different reactions of this compound(Sodium 4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-ide)SDS of cas: 129-18-0 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reference of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about A mitogenic fibrinogen receptor that differs from glycoprotein IIb-IIIa. Identification by affinity chromatography and by covalent cross-linking. Author is Levesque, Jean Pierre; Hatzfeld, Jacques; Hatzfeld, Antoinette.

The mitogenic effect of human fibrinogen on the hemopoietic cell lines Raji and JM is mediate by a specific receptor with biochem. and functional properties different from those of the platelet fibrinogen receptor, the glycoprotein complex IIb-IIIa. This work describes the identification of the mitogenic fibrinogen receptor (MFR) by 2 independent methods, affinity chromatog. and covalent crosslinking. Affinity chromatog. of surface-labeled cell extracts on fibrinogen-Sepharose revealed a 94-kDa membrane protein that bound specifically to fibrinogen-Sepharose only on cells that expressed the MFR. Its mol. mass was not modified after reduction This was confirmed by crosslinking fibrinogen to surface-labeled Raji cells using the cleavable crosslinkers, ethyleneglycolbis(succinimidyl succinate) and dithiobis(succinimidyl propionate). Complexes between fibrinogen and iodinated cell membrane proteins were immunoprecipitated by anti-fibrinogen antibodies. The biochem. cleavage of these immunoprecipitated conjugates gave rise to a 92-kDa membrane protein whose mol. mass was not modified after reduction Thus, fibrinogen binds specifically to a 92-94-kDa MFR which does not belong to the integrin family.

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Reference of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, is researched, Molecular C18H20N2O12, CAS is 70539-42-3, about Chemical stabilization of recombinant horseradish peroxidase, the main research direction is stabilization peroxidase ethylene glycol ester.Related Products of 70539-42-3.

Unglycosylated recombinant horseradish peroxidase (HRP C°) had a half life of 21 min at 65° compared with only 5 min for the plant enzyme (HRP). The half life of HRP C* at 65° increased by 5-fold following modification with ethylene glycol bis(succinic acid N-hydroxysuccinimide ester). Tolerance to 60% 1,4-dioxan also increased while tolerance to 30% DMF was unchanged.

Different reactions of this compound(Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate)Related Products of 70539-42-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ) is researched.Category: benzofurans.Dang, Li-Long; Li, Ting-Ting; Cui, Zheng; Sui, Dong; Ma, Lu-Fang; Jin, Guo-Xin published the article 《Selective construction and stability studies of a molecular trefoil knot and Solomon link》 about this compound( cas:2923-28-6 ) in Dalton Transactions. Keywords: trefoil knot Solomon link selective construction stability mol structure. Let’s learn more about this compound (cas:2923-28-6).

Two novel compounds, a mol. trefoil knot and a Solomon link, were constructed successfully through the cooperation of multiple π-π stacking interactions. A reversible transformation between the trefoil knot and the corresponding [2 + 2] macrocycle could be achieved by solvent- and guest-induced effects. However, the Solomon link maintains its stability in different concentrations, solvents and guest mols. Single-crystal X-ray crystallog. data, NMR spectroscopic experiments and ESI-MS support the synthesis and structural assignments. These synthesis methods open the door to the further development of smart materials, which will push the advancement of rational design of biomaterials.

Different reactions of this compound(Silver(I) trifluoromethanesulfonate)Category: benzofurans require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 2923-28-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Di-μ-chlorido-bis[(2,2′:6′,2′′-terpyridine-κ3N,N′,N′′)copper(II)] bis(trifluoromethanesulfonate). Author is Adrian, Rafael A.; Duarte, Jose J.; Arman, Hadi D..

In the centrosym. title complex, [Cu2Cl2(C15H11N3)2](CF3O3S)2, the CuII metal center is fivefold coordinated by two chloride ions and three nitrogen atoms of the terpyridine ligand in a distorted square-pyramidal geometry; two trifluoromethanesulfonate ions complete the outer coordination sphere. π-π stacking interactions between the pyridyl rings in adjacent mols. contribute to the alignment of the complexes in columns along the a-axis. This structure represents the first example of a binuclear dication of formula [Cu(terpy)2Cl2]2+ with trifluoromethanesulfonate as counter-ions.

Different reactions of this compound(Silver(I) trifluoromethanesulfonate)HPLC of Formula: 2923-28-6 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate, is researched, Molecular C6H11ClO3, CAS is 90866-33-4, about A recombinant ketoreductase tool-box. Assessing the substrate selectivity and stereoselectivity toward the reduction of β-ketoesters, the main research direction is ketoreductase reduction stereoselective beta keto ester.Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate.

The substrate selectivity and stereoselectivity of a series of ketoreductases were evaluated toward the reduction of two sets of β-ketoesters. Both the structural variety at β-position and the substituent at α-position greatly affected the activity and stereoselectivity of these ketoreductases. For the first set of β-ketoesters, at least one ketoreductase was found that catalyzed the formation of either (D) or (L) enantiomer of β-hydroxyesters from each substrate with high optical purity, with the only exception of Et (D)-3-hydroxy-3-phenylpropionate. For the second set of β-ketoesters with α-substituents, the situation is more complex. More commonly, a ketoreductase was found that formed one of the four diastereomers in optically pure form, with only a few cases in which enzymes could be found that formed two or more of the diastereomers in high optical purity. The continued development of new, more diverse ketoreductases will create the capability to produce a wider range of single diastereomers of 2-substituted-3-hydroxy acids and their derivatives

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)Recommanded Product: (R)-Ethyl 4-chloro-3-hydroxybutanoate require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 90866-33-4, is researched, SMILESS is O=C(OCC)C[C@@H](O)CCl, Molecular C6H11ClO3Journal, Industrial & Engineering Chemistry Research called A Complex Process of Asymmetric Synthesis of β-Hydroxy Ester by Baker’s Yeast Accompanied by Resin Adsorption, Author is Yang, Zhong-Hua; Yao, Shan-Jing; Guan, Yi-Xin, the main research direction is bakers yeast asym reduction resin adsorption.SDS of cas: 90866-33-4.

Asym. reduction of β-oxo ester to chiral β-hydroxy ester by yeast cells is one of the most promising routes for synthesis of chiral pharmaceutical intermediates. But the stereoselectivity and initial substrate concentration of this asym. reduction reaction are usually unsatisfactory. When asym. reduction of Et 4-chloro-3-oxobutanoate to chiral Et 4-chloro-3-hydroxybutanoate by baker’s yeast was chosen as the model reaction, it was investigated to improve the stereoselectivity and initial substrate concentration of this asym. reduction reaction by introducing resin to slowly release the substrate and in situ adsorb the product. The experiments indicated that the stereoselectivity could be promoted from about 78% to 95% with this technique, and the initial substrate concentration could be increased from 70 to 150 mmol/L, but the yield and stereoselectivity were still satisfactory with introducing resin.

Different reactions of this compound((R)-Ethyl 4-chloro-3-hydroxybutanoate)SDS of cas: 90866-33-4 require different conditions, so the reaction conditions are very important.

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 4-bromo-2-formylbenzoate( cas:1260795-42-3 ) is researched.Synthetic Route of C9H7BrO3.Ray, Sumit K.; Sadhu, Milon M.; Biswas, Rayhan G.; Unhale, Rajshekhar A.; Singh, Vinod K. published the article 《A General Catalytic Route to Enantioenriched Isoindolinones and Phthalides: Application in the Synthesis of (S)-PD 172938》 about this compound( cas:1260795-42-3 ) in Organic Letters. Keywords: chiral Bronsted acid catalyst tandem Mannich lactamization diazoester; isoindolinone phthalide asym preparation. Let’s learn more about this compound (cas:1260795-42-3).

Chiral Bronsted acid catalyzed enantioselective syntheses of isoindolinones, e.g. I, and phthalides have been accomplished via tandem Mannich-lactamization and aldol-lactonization reactions, resp. A variety of enantioenriched isoindolinones (up to 99% ee) and phthalides (up to 85% ee) containing α-diazoesters were afforded in excellent yields. Furthermore, a concise synthesis of (S)-PD 172938 has been demonstrated by using this protocol.

The article 《A General Catalytic Route to Enantioenriched Isoindolinones and Phthalides: Application in the Synthesis of (S)-PD 172938》 also mentions many details about this compound(1260795-42-3)Synthetic Route of C9H7BrO3, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Veterinary Pharmacology and Therapeutics called Residue profile of phenylbutazone in the rabbit. A comparative evaluation by tissue kinetics prior to and post-mortem, Author is Toutain, P. L.; Alvinerie, M.; Ruckebusch, Y., which mentions a compound: 129-18-0, SMILESS is O=C(N(C1=CC=CC=C1)N2C3=CC=CC=C3)[C-](CCCC)C2=O.[Na+], Molecular C19H19N2NaO2, COA of Formula: C19H19N2NaO2.

The disposition kinetics and residue levels of Na phenylbutazone (8 mg/kg) were studied in rabbits as a model for cattle. The results suggest that distribution of phenylbutazone can be described by a 2 compartment open model. The elimination half-time is short (2 h), and the estimation of residue levels in muscle, liver, and kidney did not differ significantly before and after bleeding. Apparently, biopsy tissue can be used to determine the tissue phenylbutazone concentration of larger species. Moreover, by using a pharmacokinetic approach based on drug concentrations in plasma, it appeared that the mean resting quantity in the peripheral compartment was very close to the exptl. data for the muscle.

The article 《Residue profile of phenylbutazone in the rabbit. A comparative evaluation by tissue kinetics prior to and post-mortem》 also mentions many details about this compound(129-18-0)COA of Formula: C19H19N2NaO2, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: CAgF3O3S. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Polymer light-emitting electrochemical cells with ultralow salt content: performance enhancement through synergetic chemical and electrochemical doping actions. Author is Hu, Shiyu; Yeh, Hung-Wei; Gao, Jun.

Polymer light-emitting electrochem. cells (PLECs) employing a silver trifluoromethanesulfonate (Ag triflate) salt are demonstrated. The red-emitting PLECs contained 0.2-1 wt% salt, but exhibited a peak luminance of 6000 cd m-2, with high efficiency and minimal efficiency roll-off. Notably, the Ag triflate cells activate more than 100 times faster than an optimized reference cell containing a potassium triflate salt. The high performance of the Ag triflate PLECs can be attributed to the partial chem. doping of the light-emitting polymer by the silver cations. The synergetic action of chem. and electrochem. doping provides a new avenue to design high-performance mixed conductor devices.

The article 《Polymer light-emitting electrochemical cells with ultralow salt content: performance enhancement through synergetic chemical and electrochemical doping actions》 also mentions many details about this compound(2923-28-6)COA of Formula: CAgF3O3S, you can pay attention to it, because details determine success or failure

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem