Category: benzofuran

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128851-73-0,6-Bromobenzofuran,as a common compound, the synthetic route is as follows.

To a stirred solution of 6-bromobenzo[b]furan (100 mg, 0.507 mmol) in 1 ,4-dioxane (15 mL), tert-butyl 6-fluoro-3-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 H-indole-1 – carboxylate (Intermediate 2, 180 mg, 0. 507 mmol), K2CO3 (210 mg, 1 .52 mmol) and Pd(dppf)CI2 (19 mg, 0.025 mmol) were added. The mixture was stirred at 80 C for 15 hrs. The solvent was removed and the residue was purified by prep-TLC (EtOAc/Petroleum Ether=1 /10) to afford 1 12.8 mg (63%) of the title compound. LC-MS for C2iH18FNO3+H+ [M+H]+ : calcd: 351 .1 ; found: 351 .8. 1 H NMR (400 MHz, CDCI3) delta [ppm]: 7.96 (d, J = 4.8 Hz, 1 H), 7.79-7.76 (m, 2H),7.71 -7.67 (m, 3H),7.50 (dd, J = 8.0 Hz,1 .6Hz, 1 H),7.06 (dd, J = 8.8, 2.4 Hz, 1 H), 6.82 (d, J = 1 .0 Hz, 1 H), 1 .70 (s, 9H).

The synthetic route of 128851-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ITEOS THERAPEUTICS; CAUWENBERGHS, Sandra; CROSIGNANI, Stefano; DRIESSENS, Gregory; DEROOSE, Frederik; (271 pag.)WO2015/140717; (2015); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

32703-79-0, 5-(tert-Butyl)isobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of substituted benzyl amine (10 mmol) and an acid anhydride (10 mmol) in glacial acetic acid (15mL) was heated under reflux for 4h. After the evaporation of the reaction mixture to dryness under reduced pressure, the residue was neutralised by a solution of sodium bicarbonate (4%) until effervescence ceased. The precipitate obtained was washed with water, dried and re-crystallised from an appropriate solvent.

32703-79-0 5-(tert-Butyl)isobenzofuran-1,3-dione 122930, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Alanazi, Amer M.; El-Azab, Adel S.; Al-Suwaidan, Ibrahim A.; Eltahir, Kamal Eldin H.; Asiri, Yousif A.; Abdel-Aziz, Naglaa I.; Abdel-Aziz, Alaa A.-M.; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 115 – 123;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.128851-73-0,6-Bromobenzofuran,as a common compound, the synthetic route is as follows.

j0041 1j To a solution of 6-bromobenzofuran (1.0 g, 5.1 mmol) in anhydrous tetrahydrofuran (15 mL) at -78 C under nitrogen was added dropwise lithium diisopropylamide (2.0 M in n-heptane, 3.1 mL, 6.2 mmol). The mixture was stirred at at -78 C for 30mm and then hexachloroethane (1.2 g, 5.1 mmol) was added dropwise. The reaction was stirred at -78 C for another one hour, then poured into water (20 mL) and extracted with ethyl acetate (2 x 30 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography [petroleum ether: ethyl acetate = 1:01 to give compound B-70 (0.36 g, 28% yield) as a colorless oil. ?H-NMR (CD3OD, 400 MHz): 7.69 (s, 1H), 7.46 (d, J=8.0 Hz, 1H), 7.40 (dd, J1=8.4 Hz, J2=1.6 Hz, 1H), 6.77 (s, 1H).

#N/A

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

Under a nitrogen stream, 5-bromobenzofuran (25 g, 0.126 mol), 4,4,4 ‘, 4,5,5,5,5-octamethyl-2,2’-bi (1,3,2-dioxaborolane) (38.67 g, 0.152 Dioxane (500 ml), and the mixture was stirred at 130 C for 12 hours. The reaction was terminated. The mixture was extracted with ethyl acetate, the water was removed with MgSO 4 and purified by column chromatography to obtain 23.23 g of benzofuran-5-yl) -4,4,5,5-etramethyl-1,3,2-dioxaborolane , Yield: 75%).

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Doosan Co., ltd; Kim, Tae Hyoung; Kim, Song Mu; Lee, Chang Jun; Sin, Jin Yong; Baek, Young Mi; Park, Ho Chul; (40 pag.)KR101599586; (2016); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-16-2, 2,3-Dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part A Preparation of 5-(2,3-dihydrobenzofuranyl) sulfonyl chloride To a solution of 3.35 g of anhydrous N,N-dimethylformamide at 0 C. under nitrogen was added 6.18 g of sulfuryl chloride, whereupon a solid formed. After stirring for 15 minutes, 4.69 g of 2,3-dihydrobenzofuran was added, and the mixture heated at 100 C. for 2 hours. The reaction was cooled, poured into ice water, extracted with methylene chloride, dried over magnesium sulfate, filtered and concentrated the crude material. This was recrystallized from ethyl acetate to afford 2.45 g of 5-(2,3-dihydrobenzofuranyl)sulfonyl chloride.

The synthetic route of 496-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; G.D. Searle & Co.; US5705500; (1998); A;; ; Patent; G.D. Searle & Co.; US5776971; (1998); A;; ; Patent; G.D. Searle & Co.; US6143788; (2000); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.588703-29-1,Methyl benzofuran-6-carboxylate,as a common compound, the synthetic route is as follows.

5.Add compounds to the reaction flask1 (5.89kg, 11.04mol, 1.0eq) and MeOH (30L),Dissolve with stirring, add 27.65% NaOH aqueous solution to the reaction solution(9L), stirred at room temperature for 1 hour, TLC analysis of raw materials was consumed.Dilute the reaction solution with 20L of water.Wash the reaction with 20L of DCM.The aqueous phase is adjusted to a pH of 2 to 3 using concentrated hydrochloric acid, and the solid content is filtered.Dry at 45 to obtain white solid compound(2.66 kg, yield: 33%).

588703-29-1 Methyl benzofuran-6-carboxylate 22481705, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Shanghai Haoyuan Pharmaceutical Co., Ltd.; Zheng Baofu; Gao Qiang; Li Shuoliang; Yang Chengwu; Ma Zhenbiao; (11 pag.)CN110684000; (2020); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem