Category: benzofuran

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

652-39-1, A solution of 4-fluoroisobenzofuran-1,3-dione (200 mg, 1.20 mmol, 1 equiv) in AcOH (4.0mL, 0.3 M)was added 2,6-dioxopiperidin-3-amine hydrochloride (218 mg, 1.32 mmol, 1.1 equiv)and potassium acetate (366 mg, 3.73 mmol, 3.1 equiv). The reaction mixture was heated to 90 C overnight, whereupon it was diluted with water to 20 mL and cooled on ice for 30 mm. The resulting slurry was filtered, and the black solid was purified by flash column chromatography on silica gel (2% MeOH in CH2C12, Rf = 0.3) to afford the title compound as a white solid (288 mg,86%). 1H NMR (500 MHz, DMSO-d6) 11.15 (s, 1H), 7.96 (ddd,J= 8.3, 7.3, 4.5 Hz, 1H), 7.82-7.71 (m, 2H), 5.17(dd,J= 13.0, 5.4 Hz, 1H), 2.90(ddd,J= 17.1, 13.9, 5.4 Hz, 1H), 2.65 -2.47 (m, 2H), 2.10-2.04 (m, 1H), MS (ESI) cald for C13H10FN2O4 [M+H] 277.06, found 277.25.

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; ROBERTS, Justin; BEHMAN, Nabet; WINTER, Georg; PHILLIPS, Andrews, J.; HEFFERNAN, Timothy, P.; BUCKLEY, Dennis; (617 pag.)WO2018/148440; (2018); A1;,
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54008-77-4,54008-77-4, 2-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 2-bromobenzofuran/2-bromobenzo[b]thiophene (2.53 mmol) in ethanol (5 mL) was added hydrazine(0.08 g, 2.53 mmol), I2 (0.03 g, 10 mol%) and alkanone (2.53 mmol).The reaction mixture was reuxed for 1e3 h. After completion ofthe reaction as monitored by TLC, the reaction mixture wasquenched with a saturated aqueous solution of Na2S2O3. Theorganic and aqueous layers were then separated. The aqueous layerwas extracted with ethyl acetate (3 50 mL). The extract waswashed with water and nally with brine. The organic layer wasdried over anhydrous Na2SO4 and concentrated by rotary evapo-rator. Finally, the residue was puried by recrystallization from ethanol.

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

Reference£º
Article; Chacko, Priya; Shivashankar, Kalegowda; Tetrahedron; vol. 74; 13; (2018); p. 1520 – 1526;,
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Benzofuran | C8H6O – PubChem

32703-79-0, 5-(tert-Butyl)isobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Zinc phthalocyanine (6) (40 mg, 0.05 mmol) and pyridine.HCl (1 g, 8.7 mmol) were dissolved in 5 mL of pyridine and the mixture was refluxed under N2 for 16 h. After the reaction mixture was cooled to room temperature, 10 mL of water was added and the product was precipitated. The precipitate was washed first with water and then with methanol. After drying in vacuo the product was puried by column chromatography on silica gel by using ethyl acetate/hexane (1/3) eluent. The product was obtained as a dark blue solid. Yield 74%, FTIR ( , cm1) : 3283, 3071, 2956, 2907, 2866, 1617, 1485, 1258, 1089, 1000, 827, 741.1H NMR (500 MHz, CDCl3) : , ppm 9.14{8.62 (8H, m, Pc-H), 8.17{8.04 (4H, m, Pc-H), 1.94{1.89 (36H, m,C-(CH3)3) , {2.67{ {3.46 (2H, m, N-H), MS: m/z 747.079 [M+H]+., 32703-79-0

32703-79-0 5-(tert-Butyl)isobenzofuran-1,3-dione 122930, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Atsay, Arma?an; Guel, Ahmet; Burkut Kocak, Makbule; Turkish Journal of Chemistry; vol. 40; 1; (2016); p. 163 – 173;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87-41-2,Isobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

6-Nitroisobenzofuran-1(3H)-one To a stirred solution of 3H-isobenzofuran-1-one (30.0 g, 0.220 mol) in H2SO4 (38 mL) was added KNO3 (28.0 g, 0.290 mol) in H2SO4 (60 mL) at 0 C. The mixture was stirred at 20 C. for 1 h. The reaction mixture was poured into ice and the resulting precipitate was filtered off. The solid was recrystallized from ethanol to give 6-nitroisobenzofuran-1(3H)-one (32.0 g, 80%). 1H NMR (300 MHz, CDCl3) delta 8.76 (d, J=2.1, 1H), 8.57 (dd, J=8.4, 2.1, 1H), 7.72 (d, J=8.4, 1H), 5.45 (s, 2H).

87-41-2, The synthetic route of 87-41-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Vertex Pharmaceuticals Incorporated; Van Goor, Fredrick F.; Burton, William Lawrence; US2015/231142; (2015); A1;,
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652-39-1, 4-Fluoroisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

652-39-1, Under argon, 10.0 g (60.2 mmol) of 4-fluoro-2-benzofuran-1,3-dione were stirred at 130¡ã C. in 50 ml of formamide for 1 h. The cooled reaction mixture was then added to ice-water. A solid precipitated out. This solid was filtered off with suction and washed with water. The product was dried under high vacuum. This gave 8.3 g (83percent of theory) of the target compound.LC-MS (method 11): Rt=0.57 min; m/z=166 (M+H)+.1H-NMR (400 MHz, DMSO-d6): delta=11.47 (br. s, 1H), 7.87 (td, 1H), 7.69-7.61 (m, 2H).

652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER SCHERING PHARMA AKTIEGESELLSCHAFT; US2011/34450; (2011); A1;,
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Benzofuran | C8H6O – PubChem

610-93-5, 6-Nitroisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,610-93-5

(a) 3-Hydroxy-6-nitro-1(3H)-isobenzofuranone (3a) A mixture of 6-nitro-1(3H)-isobenzofuranone (8.99 g, 50.0 mmol) and N-bromosuccinimide (8.9 g, 50.0 mmol) in carbon tetrachloride (135 mL) was stirred and heated under reflux for one hour during which time the reaction mixture was exposed to the light from a 275 Watt, 125 Volt Hanovia sunlamp that was situated 8 inches from the flask. After cooling, the succinimide was removed by filtration, and the filtrate was evaporated in vacuo. The oily residue was mixed with water (200 mL), and the mixture was refluxed for one hour to give a clear, colorless solution. On cooling, the Compound 3a crystallized from solution. An analytical sample was prepared by recrystallization from water; m.p. 157-160 C.; IR 3390 cm-1 (OH), 1770 cm-1 (C=O), 1 H NMR (CDCl3 -Me2 SO-d6 -D2 O) delta6.78 (s, br, 1H, H3), 7.88 (d, 1H, H4, J4,5 =9 Hz), 8.56 (d, 1H, H5, J=9 Hz), 8.62 (s, 1H, H6). Anal. Calcd. for C8 H5 NO5: C, 49.24; H, 2.58; N, 7.18; Found: C, 49.39; H, 2.58; N, 7.13.

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Merck & Co., Inc.; US4591587; (1986); A;,
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64169-34-2, 5-Bromoisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 35: Synthesis of 5-(5-Fluoro-4-hydroxymethyl-pyridin-3-yl)-3H-isobenzofuran- 1 -one Step 1 : 5-(4,4,5,5-Tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-3H-isobenzofuran-1-one (35a) A 100 round bottom flask was charged with 5-bromo-3H-isobenzofuran-1-one (750 mg, 3.52 mmol), bis(pinacolato)diboron (894 mg, 3.52 mmol), potassium acetate (691 mg, 7.04 mmol) and 1,4-dioxane (25 mL). The reaction mixture was evacuated and flushed with N2 twice followed by addition of PdClz(dppf).CH2CI2 adduct (144 mg, 0.176 mmol). The reaction was stirred under N2 at 100 “C overnight. The reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with water twice. The organic layer was dried over sodium sulfate and concentrated in vacuo. The crude was purified using silica gel flash chromatography employing heptane-ethyl acetate(7:3) to afford 5-(4,4,5,5-tetramethyl- [1 ,3,2]dioxaborolan-2-yl)-3H-isobenzofuran-1-one., 64169-34-2

64169-34-2 5-Bromoisobenzofuran-1(3H)-one 603144, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; ALLAN, Martin; CHAMOIN, Sylvie; HU, Qi-Ying; IMASE, Hidetomo; PAPILLON, Julien; WO2011/61168; (2011); A1;,
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59434-19-4, 4-Aminophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59434-19-4, A mixture of 4-aminoisobenzofuran-1(3H)-one (149 mg, 1 mmol) and nicotinaldehyde (268 mg, 2.5 mmol) in ethyl propionate (10 mL) was cooled to 0 C. A solution of sodium methoxide in methanol [sodium (93 mg, 4 mmol) in methanol (3 mL)] was then added dropwise. After the addition, the mixture was stirred at 25 C. for 16 hr. The mixture was quenched with water (5 mL) and solvent was removed in vacuum. The residue was dissolved in water, and then extracted with ethyl acetate (50 mL¡Á3). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated to give crude product. The crude product was purified by prep-HPLC to give methyl 4-oxo-2,3-di(pyridin-2-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate (72 mg, yield 20%) and ethyl 4-oxo-2,3-di(pyridin-2-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate (14 mg, yield 3%) as a light yellow solid. LC-MS (ESI) m/z: 360(M+1)+ (methyl 4-oxo-2,3-di(pyridin-2-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate); 374(M+1)+(ethyl 4-oxo-2,3-di(pyridin-2-yl)-1,2,3,4-tetrahydroquinoline-5-carboxylate)

59434-19-4 4-Aminophthalide 12284649, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

Dissolve 2,3-dihydrobenzofuran (1,5 g, 41.6 mmol) in dichloromethane (35 mL),Br2 (6.65 g, 41.6 mmol) was weighed and dissolved in dichloromethane (15 mL). The mixture was added dropwise to the above mixture within 45 minutes at room temperature, and the mixture was stirred at room temperature for 2 hours. After the reaction was completed, a saturated NaHSO3 solution (25 mL) was added to quench, and extracted with dichloromethane (15 mL ¡Á 3). The separated organic layer was washed with water, dried over anhydrous Na2SO4, and concentrated under reduced pressure to obtain the target compound as a white solid 7.5 g, yield: 91%. This white solid was 5-bromo-2,3-dihydrobenzofuran (the compound 2)., 496-16-2

The synthetic route of 496-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Taizhou Polytechnic College; Zhang Maofeng; Zhang Yanmei; Wang Lizhong; Wu Xishan; (7 pag.)CN110452201; (2019); A;,
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Benzofuran | C8H6O – PubChem

942-06-3, 4,5-Dichlorophthalic Anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of anhydride (1 mmol), formamide (1.1 mmol for monoanhydrides and 2.2 mmol for dianhydrides) and 1 g clay was ground together in a mortar using pestle for the time described in Table 1. The reaction mixture was warmed. After completing the reaction (monitored by TLC, after observing no anhydride presence in the reaction mixture), the product was extracted by washing clay with chloroform (2¡Á15 mL), the solvent was removed under vacuum to afford the relevant N-unsubstituted cyclic imide. The solid imide was washed thoroughly with water, dried, and then recrystallized from ethanol. The solid clay portion was washed with methanol and dried at 120 ¡ãC under a reduced pressure to be reused in the subsequent reactions which showed the gradual decrease in the activity (Table 1). Isolated products were characterized by melting points, IR, 1H NMR spectrometric data and were compared with the literature or authentic samples., 942-06-3

The synthetic route of 942-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Marvi, Omid; Journal of the Chilean Chemical Society; vol. 62; 2; (2017); p. 3501 – 3504;,
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