With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.
Dissolve 2,3-dihydrobenzofuran (1,5 g, 41.6 mmol) in dichloromethane (35 mL),Br2 (6.65 g, 41.6 mmol) was weighed and dissolved in dichloromethane (15 mL). The mixture was added dropwise to the above mixture within 45 minutes at room temperature, and the mixture was stirred at room temperature for 2 hours. After the reaction was completed, a saturated NaHSO3 solution (25 mL) was added to quench, and extracted with dichloromethane (15 mL ¡Á 3). The separated organic layer was washed with water, dried over anhydrous Na2SO4, and concentrated under reduced pressure to obtain the target compound as a white solid 7.5 g, yield: 91%. This white solid was 5-bromo-2,3-dihydrobenzofuran (the compound 2)., 496-16-2
The synthetic route of 496-16-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Taizhou Polytechnic College; Zhang Maofeng; Zhang Yanmei; Wang Lizhong; Wu Xishan; (7 pag.)CN110452201; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem