Category: 42933-43-7

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The 2,3-Dihydrobenzofuran-5-amine (1A) (2.0g, 14 . 80mmol) is added to the hydrochloric acid in (14.6 ml, 3N), cooling to -5 ¡ãC, dropping sodium nitrite (1.2g, 17 . 80mmol) of water (8 ml) solution, after dripping, in 0 ¡ãC reaction 30 minutes, slowly adding sodium acetate (2.1g, 25 . 6mmol), adjusting reaction solution pH=5-6, in 0-5 ¡ãC lower, dropping ethyl 2-chloroacetoacetate(2.4g, 14 . 80mmol) methanol (5 ml) solution, to reaction at room temperature 2 hours. Adding ethyl acetate to the reaction solution (20 ml), liquid, organic phase with saturated salt water (30 ml) washing, dry anhydrous sodium sulfate, filtered, concentrated under reduced pressure, the residue is purified by silica gel column chromatography (ethyl acetate/petroleum ether (v/v) =1:99-1:9) to obtain the title compound ethyl 2-chloro-2-(2-(2,3-dihydrobenzofuran-5-yl)hydrazono)acetate(1B), yellow solid (200 mg, yield 5percent).

42933-43-7, As the paragraph descriping shows that 42933-43-7 is playing an increasingly important role.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO LTD; WEI, YONGGANG; QIU, GUANPENG; LEI, BAILIN; LU, YONGHUA; (120 pag.)CN104395312; (2016); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: Preparation of 5-acetylamino-2,3-dihydrobenzofuran [Show Image] The product (5.2 g, 38.5 mmol) obtained in Step 2 was dissolved in AcOH (20 mL) and Ac2O (5 mL), heated to 60¡ãC, reacted for 12 h, and concentrated to obtain a crude product (6 g, 88.0percent).

42933-43-7, The synthetic route of 42933-43-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Xuanzhu Pharma Co., Ltd.; EP2532665; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42933-43-7,2,3-Dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

2,3-dihydro-benzofuran-5-amine (1A) (5.7 g, 42.20 mmol) was added to hydrochloric acid (10.2 mL, 12N) water (25 mL) was cooled to -5 ¡ã C to 0 ¡ã C, solution of sodium nitrite (3.2 g, 46.4 mmol) in water (20 mL) solution, after the addition was complete, 0 ¡ã C for 30 minutes to obtain a diazonium salt solution, standby; then sodium acetate (7.9 g , 97.1 mmol) in water (25 ml) with 1-chloro-1- (methylsulfonyl) propyl-2-one (7.2g, 42.2 mmol) in ethyl acetate (70 mL) mixed solution, maintaining 0 ¡ã C, the diazonium salt solution was slowly alternate dropwise added to the mixture, after the addition was complete, the reaction at room temperature for 4 hours. The reaction solution was extracted stratification, the organic phase dried over anhydrous sodium sulfate, and concentrated under reduced pressure, the residue was purified by silica gel column chromatography (ethyl acetate / petroleum ether (v / v) = l: 4) to give the title compound Nu-(2,3-dihydrobenzofuran-5-yl)-1-methylsulfonylmethanehydrazonoyl chloride (12B) as a yellow solid (1.3 g, yield 11.2percent).

42933-43-7, The synthetic route of 42933-43-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO LTD; WEI, YONGGANG; QIU, GUANPENG; LEI, BAILIN; LU, YONGHUA; (120 pag.)CN104395312; (2016); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5; Preparation of N-(4-tert-butylphenyl)-2,3-dihydro-1-benzofuran-5-amine; [Show Image] To a flask equipped with a magnetic stirrer, reflux condensor, and nitrogen inlet was added 2,3-dihydro-1-benzofuran-5-amine (11.6 grams, 85.8 mmoles, prepared as in Example 23 of U.S. Pat. No. 20040029932), 4-tert-butyl bromobenzene (18.1 grams, 85 mmoles), tris(dibenzylideneacetone)dipalladium (0) (1.6 grams, 1.7 mmoles), rac-2,2′-bis(diphenylphosphino)-1,1′-binapthyl (2.1 grams, 3.4 mmoles), sodium tert-butoxide (16.4 grams, 0.17 moles) and anhydrous toluene (100 mL). The contents of the flask were refluxed for three days; cooled to room temperature; and filtered through a pad of silica gel. The silica gel pad was then eluted with dichloromethane (150 mL). The combined organic layers were concentrated in vacuo to yield a dark solid. The solid was chromatographed on silica gel, eluting with hexane/ethyl acetate (20:1) to afford 10 grams of the desired product as a white solid. 1H NMR (CDCl3) delta 7.25 (d, 2H), 6.95 (s, 1H), 6.85 (d, 3H), 6.7 (d, 1H), 5.4 (bs, 1H), 4.5 (t, 2H), 3.15 (t, 2H), 1.3 (s, 9H)., 42933-43-7

As the paragraph descriping shows that 42933-43-7 is playing an increasingly important role.

Reference£º
Patent; Chevron Oronite Company LLC; EP1801104; (2007); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42933-43-7,2,3-Dihydrobenzofuran-5-amine,as a common compound, the synthetic route is as follows.

Ac2O (2 equiv) and pyridine (1 equiv) were added dropwise to a stirred solution of compound 7 or 8, respectively, (1 equiv) in dioxane (4 mL) at 0C and the solution was stirred at 20C for 16 h. The solution was diluted with water (50 mL) and extracted with ethyl acetate (350 mL). The organic layer was washed with brine, dried over MgSO4, and then evaporated to give 9 (99%) as a brown solid or 10 (86%) as a white solid

42933-43-7, 42933-43-7 2,3-Dihydrobenzofuran-5-amine 3841102, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Lee, Jeewoo; Tran, Phuong-Thao; Hoang, Van-Hai; Thorat, Shivaji A.; Kim, Sung Eun; Ann, Jihyae; Chang, Yu Jin; Nam, Dong Woo; Song, Hyundong; Mook-Jung, Inhee; Lee, Jiyoun; Bioorganic and Medicinal Chemistry; vol. 21; 13; (2013); p. 3821 – 3830;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem