Category: 13196-11-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13196-11-7,Benzofuran-6-ol,as a common compound, the synthetic route is as follows.

Tribromide (2.86 g, 10 mmol) was dissolved in chloroform (10 mL)Cooled to -50 , slow6-hydroxy-2,3-dihydrobenzofuran (1.36 g, 10 mmol) and triethylamine (1.212 g, 12Mmol) in dichloromethane (10 mL)The After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C2 hours. The reaction was further cooled to -60 C and L-alanine-4-fluorobenzyl ester hydrochloride was addedSalt (2.1 g, 9 mmol) was added dropwise to a solution of triethylamine (2.53 g, 25 mmol) in dichloromethane (5ML). After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C for 2 hours. Further the reaction is carried outWas cooled to -60 C and pentafluorophenol (1.66 g, 9 mmol) and triethylamine (1.52 g, 15Mmol) in dichloromethane (10 mL). After completion of the dropwise addition, the cold bath was removed and the mixture was stirred at 25 C6 hours. The reaction was complete and the reaction system was poured into ice water and extracted with dichloromethane. CollectionAnd the organic phase was washed with saturated brine aqueous solution, dried and concentrated by filtration to give the intermediate compound(6-fluorobenzyl) -2 – ((pentafluorophenoxy) (benzofuran-6-oxy) phosphoryl) amino)Propionate.

13196-11-7, The synthetic route of 13196-11-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Kelun Pharmaceutical Research Institute Co., Ltd.; Liu, Gang; Yu, Nan; Wu, Yongyong; Tang, Zuijian; Zheng, Xiaozhou; Chen, Qiangqiang; Deng, Hanwen; Duan, Xiaofan; Song, Shuai; Yang, Long; Li, Shai; Huang, Haitao; Zhang, Yitao; Zhao, Mingliang; Deng, Hua; Zhong, Wei; Li, Donghong; Ceng, Hong; Guo, Xianfen; Song, Hongmei; Tao, Lihua; Wang, Lichun; Wang, Jingyi; Other inventors request an unlisted name; (127 pag.)CN106554382; (2017); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13196-11-7,Benzofuran-6-ol,as a common compound, the synthetic route is as follows.

General procedure: To a mixture of 6 (1 mmol) and potassium carbonate (3 mmol) in anhydrous DMF (5 ml) was added corresponding benzo cyclic phenol (1.1 mmol). After the resulting mixture was heated at 90-110 C for 3-10 h, the reaction was cooled to room temperature and poured into water (15 ml). The mixture was extracted with ethyl acetate for three times, and the organic layers were combined, washed with saturated brine (20 ml x 2), dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was purified by flash column chromatography to yield the desired compound.

13196-11-7, 13196-11-7 Benzofuran-6-ol 128844, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Zou, Qingan; Duan, Hongliang; Ning, Mengmeng; Liu, Jia; Feng, Ying; Zhang, Liming; Zhu, Junjie; Leng, Ying; Shen, Jianhua; European Journal of Medicinal Chemistry; vol. 82; (2014); p. 1 – 15;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

13196-11-7, Benzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of Example 5b (0.26 g, 1.9 mmol, 1 eq.), triethylamine (0.65 g, 6.5 mmol, 3.4 eq.), and magnesium dichloride (0.29 g, 3.1 mmol, 1.6 eq.) in acetonitrile (25 mL) was added paraformaldehyde (0.36 g, 13 mmol, 6.8 eq.) portionwise. The resulting mixture was refluxed for 3.5 hours at which time TLC revealed that all the starting material was consumed. The reaction mixture was acidified with 6 N HCl, concentrated and extracted with ether (3* 15 mL). The ether extracts were washed with water, brine, dried over Na2S04 and concentrated under reduced pressure to give the desired product (Example 5c, 0.22 g, crude yield 65%) as yellow oil., 13196-11-7

13196-11-7 Benzofuran-6-ol 128844, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (212 pag.)WO2017/218960; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem