Month: February 2023

Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis was written by Takahashi, Daisuke;Matsunaga, Eri;Yamashita, Tomohiro;Caaveiro, Jose M. M.;Abe, Yoshito;Ueda, Tadashi. And the article was included in Biochemical and Biophysical Research Communications in 2022.Safety of Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) This article mentions the following:

AL amyloidosis is a life-threatening disease characterized by the deposition of amyloidogenic Ig light chain secreted from clonal plasma cells. Here we established an in-vitro screening system of amyloid inhibition of a variable domain in λ6 light chain mutant (Vλ6), Wil, and screened a food-additive compound library to identify compounds inhibiting the fibril formation. We found gossypetin and isoquercitrin as novel inhibitors. NMR anal. showed that both compounds directly interacted with natively-folded Wil, and proteolysis experiments demonstrated that these compounds conferred proteolytic resistance, suggesting that the compounds enhance the kinetic stability of Wil. Since gossypetin and isoquercitrin specifically interacted with the protein at micromolar concentrations, these compounds could be used as lead to further develop inhibitors against AL amyloidosis. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0Safety of Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Safety of Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enhancing the Thermal Stability of Solution-Processed Small-Molecule Semiconductor Thin Films Using a Flexible Linker Approach was written by Gasperini, Andrea;Jeanbourquin, Xavier A.;Rahmanudin, Aiman;Yu, Xiaoyun;Sivula, Kevin. And the article was included in Advanced Materials (Weinheim, Germany) in 2015.Recommanded Product: 128851-73-0 This article mentions the following:

The authors demonstrate a flexible-linker strategy for mol. organic semiconductors using a common small-mol. donor, 3,6-bis(5-(benzofuran-2-yl)thiophen-2-yl)-2,5-bis(2ethylhexyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione, coded as DPP(TBFu)₂. When the flexibly linked material is employed as an additive in thin films, a unique level of control is observed over the morphol. and the thermal stability of pure donor films in transistor devices and in blends with PC₆₁BM for BHJ photovoltaics. The synthesis of the flexibly linked DPP(TBFu)₂ derivative [coded FL-DPP(TBFu)₂] is shown schematically. The Stille-coupling polycondensation between the brominated diketopyrrolopyrrole core and the stannylated benzofuran dimer followed by standard purification and finally preparatory size exclusion chromatog. afforded the pure polymer with a number average mol. weight, M_n of 10 kDa and a PDI of 1.4 ( n = 11 – 15) in the hundred-milligram scale. In the experiment, the researchers used many compounds, for example, 6-Bromobenzofuran (cas: 128851-73-0Recommanded Product: 128851-73-0).

6-Bromobenzofuran (cas: 128851-73-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 128851-73-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A computational study on active constituents of Habb-ul-aas and Tabasheer as inhibitors of SARS-CoV-2 main protease was written by Shamsi, Shariq;Anjum, Hina;Shahbaaz, Mohd;Khan, Mohd Shahnawaz;Ataya, Farid S.;Alamri, Alya;Alhumaydhi, Fahad A.;Husain, Fohad Mabood;Rehman, Tabish Md.;Mohammad, Taj;Islam, Asimul;Anjum, Farah;Shamsi, Anas. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Computed Properties of C8H8O This article mentions the following:

A respiratory pandemic known as coronavirus disease-19 (COVID-19) has created havoc since it emerged from Wuhan, China. COVID-19 is caused by a newly emerged SARS coronavirus (SARS-CoV) with increased pathogenicity named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Due to the lack of understanding of the mechanism of pathogenesis, an effective therapeutic option is unavailable. Epidemics described in Unani ancient literature include nazla-e-wabai and humma-e-wabai, and most of the symptoms of COVID-19 resemble nazla-e-wabai. Hence, in light of Unani literature, the treatment of COVID-19 can be managed with the composites prescribed in Unani medicine for nazla-e-wabai. In this study, a structure-based drug design approach was carried out to check the effectiveness of the pharmacol. active constituents of the Unani composites prescribed to treat nazla-e-wabai against SARS-CoV-2. We performed mol. docking of the active constituents of these composites against the main protease (M^pro), a potential drug target in SARS-CoV-2. Using detailed mol. docking anal., Habb-ul-aas and Tabasheer were identified as potential inhibitors of SARS-CoV-2 M^pro. The active constituents of both these composites bind to the substrate-binding pocket of SARS-CoV-2 M^pro, forming interactions with key residues of the binding pocket. Mol. dynamics (MD) simulation suggested the binding of active constituents of Habb-ul-aas with SARS-CoV-2 M^pro with a strong affinity as compared to the constituents of Tabasheer. Thus, this study sheds light on the use of these Unani composites in COVID-19 therapeutics. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Computed Properties of C8H8O).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Computed Properties of C8H8O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Modifications of biological activity following the addition of a second nitrofuran ring to nitroarenofuran homocycles was written by Bilger, Christine;Demerseman, Pierre;Buisson, Jean Pierre;Royer, Rene;Gayral, Philippe;Fourniat, Jacky. And the article was included in European Journal of Medicinal Chemistry in 1987.Name: 2-Nitrobenzofuran This article mentions the following:

2,7-Dinitrobenzo[1,2-b:4,3-b‘]difuran (I) was prepared by the direct nitration of II and the derivatives nitrated in the α-positions of the heterocycles, naphtho[2,1-b:7,6-b‘]difuran, naphtho[2,1-b:6,5-b‘]difuran, naphtho[1,2-b:5,6-b‘]difuran and anthra[2,1-b:6,5-b‘]difuran were obtained by the condensation of bromonitromethane with the appropriate bis[ortho-hydroxy(formyl)]naphthalenes or -anthracene. The antibacterial and antiprotozoal activity of these compounds was compared with that of condensed systems containing a single furan ring (e.g., 2-nitrobenzofuran, 2-nitronaphtho[2,1-b]furan, etc.). Trichomonas vaginalis, Entamoeba histolytica, Staphylococcus aureus, And Escherichia coli were used as the test organisms. The dinitroarenodifurans were more active against the microorganisms than the nitroarenofurans. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Name: 2-Nitrobenzofuran).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 2-Nitrobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

High-throughput extracellular pH monitoring and antibiotics screening by polymeric fluorescent sensor with LCST property was written by Pan, Tingting;Yang, Cheng;Li, Jiaze;Jiang, Jiapei;Wen, Jiaxing;Wang, Zijin;Zhong, Ke;Tian, Yanqing;Chen, Meiwan. And the article was included in Methods (Amsterdam, Netherlands) in 2019.Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Herein, we synthesized two polymers for pHe monitoring which are soluble in water at room temperature with easy operations and high reproducibility among various micro-plate wells for high-throughput anal. P1 (P(OEGMA-co-MEO₂MA-co-pHS)) and P2 (P(OEGMA-co-pHS)) were synthesized via the Reversible Addition Fragmentation Chain Transfer (RAFT) copolymerization of OEGMA, MEO₂MA and the pH sensitive fluorescence moiety N-fluoresceinyl methacrylamide (pHS). P1 is soluble in water at room temperature (25°C) while insoluble at the temperature above 33°C, indicating its feature of lower critical solution temperature (LCST) at 33°C. Further P1 showed higher pH sensitivity and photostability than P2 (without LCST property) when used at physiol. temperature (37°C). Thus, P1 was chosen to in-situ monitor the micro-environmental acidification of E. coli, Hela and Ramos cells during their growth, and the metabolism inhibiting activity of a representative antibiotic, ampicillin. Cell concentration-dependent cellular acidification and drug concentration-dependent inhibition of cellular acidification were observed, demonstrating that the LCST polymer (P1) is suitable for real-time cellular acidification monitoring as well as for high-throughput drug screening. This study firstly demonstrated the use of a LCST polymeric sensor for high-throughput screening of antibiotics and investigation of cell metabolism In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Name: 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The magnitude and management of functional constipation at pediatric gastroenterology clinics: A survey study of various countries was written by Osatakul, Seksit;Benninga, Marc A.;Thapar, Nikhil;Treepongkaruna, Suporn;Puetpaiboon, Areeruk. And the article was included in Journal of Gastroenterology and Hepatology in 2022.COA of Formula: C18H26ClN3O3 This article mentions the following:

There have been no large-scale epidemiol. study of functional constipation of pediatric gastroenterol. services. This survey was undertaken to investigate the prevalence of functional constipation and magnitude of related problems in hospital settings of various countries as well as the practice of pediatric gastroenterologists in management of these conditions. The survey was conducted by sending questionnaires to members of Societies for Pediatric Gastroenterol. Hepatol. and Nutrition of various continents. A total of 274 pediatric gastroenterologists from 41 countries participated in this study. Functional constipation accounted for overall 30% of patients attending pediatric gastroenterol. outpatient clinics. In comparison with non-western countries, respondents from western countries reported significantly higher median annual numbers of new patients with intractable functional constipation (10 [4,25] vs 5 [2,10], P < 0.001), dyssynergic defecation (3 [0,15] vs 1 [0,4], P < 0.001), and colonic inertia (2 [0,5] vs 0 [0,1], P < 0.001). The use of high dose polyethylene glycol for fecal disimpaction was significantly more commonly among respondents from western countries, whereas rectal enema was significantly more favored in non-western countries. Respondents from different continents reported significant discrepancies in choices of investigations and management of patients with dyssynergic defecation and colonic inertia. Functional constipation is a major problem for pediatric gastroenterol. outpatient services worldwide. There were significant variations in the investigations of choice and therapeutic management of functional constipation, intractable functional constipation, and related problems among pediatric gastroenterologists of different geog. regions. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8COA of Formula: C18H26ClN3O3).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.COA of Formula: C18H26ClN3O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

UPLC-MS identification and anticomplement activity of the metabolites of Sophora tonkinensis flavonoids treated with human intestinal bacteria was written by Jin, Xin;Lu, Yan;Chen, Shaoxin;Chen, Daofeng. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2020.Category: benzofurans This article mentions the following:

Anticomplement activity played an important role in anti-inflammatory effects of traditional Chinese herbs. The total flavonoids of Sophora tonkinensis (TFST) were inactive on the complement system but showed obvious anticomplement activity after incubated with human intestinal bacteria in vitro. In order to discover the metabolic activation of TFST by intestinal flora, the constituents of TFST and its metabolites were identified by UPLC-ESI-LTQ/MS. Their anticomplement activities were evaluated through the classical and alternative pathway. As a result, eighteen flavonoids were identified, including seven flavonoid glycosides, five aglycons and six isoprenylated flavonoids. All the glycosides (daidzein-4′-glucoside-rhamnoside, sophorabioside, rutin, isoquercitrin, quercitrin, ononin, trifolirhizin) were metabolized into their corresponding aglycons in different extent by human intestinal bacteria, resulting in the contents of the five aglycons were highly increased in 24 h. However, no changes have occurred on the six isoprenylated flavonoids. Interestingly, three aglycons (quercetin, formononetin and maackiain) had significantly more potent anticomplement activities than their prototype glycosides. The results indicated that the enhancement of TFST anticomplement activity was attributed to the active aglycons, especially formononetin and quercetin, produced by human intestinal bacteria. These aglycons are likely to be among the potential active components of S. tonkinensis for its inhibiting inflammation effects. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Category: benzofurans).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Electron transfer in triarylmethane lactones: from the sub-100 fs regime to solvent control was written by Schmidhammer, U.;Karpiuk, J.;Lochbrunner, S.;Riedle, E.. And the article was included in Springer Series in Chemical Physics in 2007.Computed Properties of C26H29N3O2 This article mentions the following:

The electron transfer in triarylmethane lactones can be as fast as 50 fs exceeding the inertial solvation. Changing the character of the excited state switches to complete solvent control. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Computed Properties of C26H29N3O2).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Computed Properties of C26H29N3O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chain diffusion and exchange during build-up of hydrogen-bonded polymer complex film was written by Rehan, Kiran;Su, Chao;Nie, Jing;Xu, Jian;Yang, Shuguang. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2018.Formula: C20H13NO5 This article mentions the following:

Poly(vinylpyrrolidone) (PVPON) and poly(acrylic acid) (PAA) were layer-by-layer (LbL) assembled to prepare thin film based on hydrogen bonding. A series of simple experiments were designed to investigate polymer chain diffusion and exchange behaviors of hydrogen-bonded PVPON/PAA film. PAA was labeled with fluorescence dye, fluorescein amine (FAM). The prepared (PVPON/PAA)₂₀ films were immersed into PAA solution, PVPON solution and PAA-FAM solution sep., for a period that was much longer than the assembly time, and the thickness, the composition and the characteristic absorbance of the film were monitored. The experiment results indicated that polymers not only diffused into the thin film from the assembly solution but also diffused out from the thin film into the assembly solution, i.e. there existed a polymer chain exchange. The growth of hydrogen-bonded PVPON/PAA film was related with polymer chain diffusion and exchange at a certain time scale. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Formula: C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Thermoresponsive Dynamic Covalent Polymers with Tunable Properties was written by Li, Jingyi;Yang, Shixia;Wang, Lin;Wang, Xiaobei;Liu, Li. And the article was included in Macromolecules (Washington, DC, United States) in 2013.HPLC of Formula: 3326-34-9 This article mentions the following:

A bisaldehyde-containing trithiocarbonate chain transfer agent was prepared and mediated the synthesis of polymers with bisaldehyde-functionalized α-termini by reversible addition-fragmentation chain transfer (RAFT) radical polymerization The α-termini of RAFT-derived thermoresponsive poly-(N-isopropylacrylamide) was conjugated with hydrazides via reversible acylhydrazone bonds. Introduction of hydrophilic end-groups generated a dynamic covalent polymer with “isothermal” lower critical solution temperature (LCST) response to medium pH and dynamic chain exchange character. A biofunctional dynamic covalent polymer was prepared by conjugation with biotin hydrazide. Under appropriate reaction conditions, a dynamic covalent block copolymer with an aldehyde group at the junction point was constructed through a reversible arylhydrazone linkage by coupling with acylhydrazide-terminated poly-(ethylene glycol). The dynamic covalent block copolymer exhibited pH-dependent LCST. The remaining aldehyde group was used to react with amino-containing mols. Bioconjugated dynamic covalent block copolymers containing reversible imine and arylhydrazone linkages were constructed by conjugation of the block copolymer to glucosamine and protein. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9HPLC of Formula: 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.HPLC of Formula: 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem