Day: February 27, 2023

Deaminative Arylation of Amino Acid-derived Pyridinium Salts was written by Hoerrner, Megan E.;Baker, Kristen M.;Basch, Corey H.;Bampo, Earl M.;Watson, Mary P.. And the article was included in Organic Letters in 2019.Product Details of 257288-19-0 This article mentions the following:

A Suzuki-Miyaura cross-coupling of α-pyridinium esters and arylboroxines has been developed. Combined with formation of the pyridinium salts from amino acid derivatives, this method enables amino acid derivatives to be efficiently transformed into α-aryl esters and amides. Under the mild conditions, broad functional group tolerance on both the amino acid derivatives and the arylboroxine are observed, including protic functional groups. Mechanistic studies support an alkyl radical intermediate, similar to other cross-couplings of alkylpyridinium salts. In the experiment, the researchers used many compounds, for example, (S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride (cas: 257288-19-0Product Details of 257288-19-0).

(S)-Methyl 2-amino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanoate hydrochloride (cas: 257288-19-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 257288-19-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Coulomb and Overlap Self-Similarities: A Comparative Selectivity Analysis of Structure-Function Relationships for Auxin-like Molecules was written by Ferro, Noel;Gallegos, Ana;Bultinck, Patrick;Jacobsen, Hans-Joerg;Carbo-Dorca, Ramon;Reinard, Thomas. And the article was included in Journal of Chemical Information and Modeling in 2006.COA of Formula: C10H8O3 This article mentions the following:

Auxins are defined mainly by a set of physiol. actions, but the structure-effect relationship still is based on chem. intuition. Currently a well-defined auxin mol. structure is not available. The existence of different auxin binding proteins and mechanisms of auxin action, the wide diversity of the auxin mols., and the pleiotropic effects of auxin imply a completely different mechanism as described for the animal hormone concept. Here, we present a computational approach dealing with semiempirical optimizations of the auxin mols. themselves, which represent a number of about 250 different chem. structures. Our approach uses mol. quantum similarity measures and addnl. quantum variables for the anal. of auxin-like mols. The finding of similarities in mols. by focusing basically on their electron structure results in new insights in the relationship of the different auxin groups. Addnl. statistical anal. allows the identification of relationships between similarity groups and their biol. activity, resp. It is postulated that the auxin-like mol. recognition depends more on specific mol. assembling states than on a specific ring system or side chain. In the experiment, the researchers used many compounds, for example, 2-Benzofuranacetic acid (cas: 62119-70-4COA of Formula: C10H8O3).

2-Benzofuranacetic acid (cas: 62119-70-4) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Microcapsule particle size and size distribution and its influencing factors was written by Zhen, Zhaohui;Wang, Zhengshun. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2013.Recommanded Product: 1552-42-7 This article mentions the following:

The paper studied the microcapsule particle size, size distribution and its influencing factors with melamine formaldehyde resin (MF-resin) as wall and CVL as core. The results indicated that the microcapsules mean particle size decreased, size distribution became narrow with the increase of emulsifying time and shear rate. Low pH value would make the microcapsules have rough surface morphol. and large particle size. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Recommanded Product: 1552-42-7).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 1552-42-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST). was written by Mahadevan, Daruka;Theiss, Noah;Morales, Carla;Stejskal, Amy E;Cooke, Laurence S;Zhu, Min;Kurtzman, Drew;Swart, Rachel;Ong, Evan;Qi, Wenqing. And the article was included in Oncotarget in 2015.COA of Formula: C23H21N5O3S This article mentions the following:

BACKGROUND: c-Kit/α-PDGFR targeted therapies are effective for gastrointestinal stromal tumors (GIST), but, >50% develop drug resistance. METHODS: RTK expression (c-Kit, c-Met, AXL, HER-1, HER-2, IGF-1R) in pre-/post-imatinib (IM) GIST patient samples (n=16) and 4 GIST cell lines were examined for RTK inhibitor activity. GIST-882 cells were cultured in IM every other day, cells collected (1 week to 6 months) and analyzed by qRT-PCR and Western blotting. RESULTS: Immunohistochemistry pre-/post-IM demonstrated continued expression of c-Kit and HER1, while a subset expressed IGF-1R, c-Met and AXL. In GIST cells (GIST-882, GIST430/654, GIST48) c-Kit, HER1 and c-Met are co-expressed. Acute IM over-express c-Kit while chronic IM, lose c-Kit and HER-1 in GIST882 cells. GIST882 and GIST430/654 cells have an IC50 0.077 and 0.59 µM to IM respectively. GIST48 have an IC50 0.66 µM to IM, 0.91 µM to amuvatinib [AMU] and 0.67 µM to erlotinib (Erl). Synergistic combinations: GIST882, AMU + Erl (CI 0.20); IM + AMU (CI 0.50), GIST430/654, IM + afatinib (CI 0.39); IM + AMU (CI 0.42), GIST48, IM + afatinib (CI 0.03); IM + AMU (CI 0.04); AMU + afatinib (CI 0.36); IM + Erl (CI 0.63). CONCLUSION: Targeting c-Kit plus HER1 or AXL/c-Met abrogates IM resistance in GIST. In the experiment, the researchers used many compounds, for example, N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3COA of Formula: C23H21N5O3S).

N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C23H21N5O3S

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis and Characterization of Biodegradable Poly(ester amide)s with Pendant Amine Functional Groups and in Vitro Cellular Response was written by Deng, Mingxiao;Wu, Jun;Reinhart-King, Cynthia A.;Chu, Chih-Chang. And the article was included in Biomacromolecules in 2009.Reference of 92557-80-7 This article mentions the following:

The purpose of this study was to use a convenient synthetic strategy to prepare a new family of biodegradable amino acid-based poly(ester amide)s (PEAs) with pendant amine groups along the polymer backbone, and investigate the applications of the new polymers in the biomedical area. Two amino acids, L-phenylalanine (Phe) and L-lysine (Lys), were used as the model amino acid compounds to illustrate the synthesis, characterization, and biol. property of this new family of functional PEAs. These new PEAs were obtained by two-step reactions, the ring-opening reaction of ε-(benzyloxycarbonyl)-L-lysine N-carboxyanhydride (Z-LysNCA) with L-phenylalanine hexane-1,6-diol diester p-toluenesulfonate (Phe-6), and subsequently solution polycondensation with di-p-nitrophenyl sebacoyl (NS). The benzyloxycarbonyl (Z) protective groups of the resulting polymer (PEA-Z-Lys) were completely removed to produce the new functional PEAs having free pendant amine groups (PEA-Lys-NH₂). The level of the pendant amine groups on the PEA-Lys-NH₂ could be tailored by adjusting the Phe-6 to Z-LysNCA feed ratio. Analyses of FTIR, ¹H NMR, ¹³C NMR spectra, and DSC revealed the desired chem. structures and thermal property of PEA-Z-Lys as well as the final functional PEA-Lys-NH₂. The free pendant amine groups were used to chem. conjugate a fluorescent dye to demonstrate the utility of this new family of functional PEA. An in vitro cell culture study of these functional PEAs showed that they supported the proliferation of bovine aortic endothelial cell slightly better than gelatin-coated glass coverslips. This new family of biodegradable functional PEA with free amine groups may have great potential applications for biomedical and pharmacol. fields. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Reference of 92557-80-7).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 92557-80-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The greening of peptide synthesis was written by Lawrenson, Stefan B.;Arav, Roy;North, Michael. And the article was included in Green Chemistry in 2017.Category: benzofurans This article mentions the following:

The synthesis of peptides by amide bond formation between suitably protected amino acids is a fundamental part of the drug discovery process. However, the required coupling and deprotection reactions are routinely carried out in dichloromethane and DMF, both of which have serious toxicity concerns and generate waste solvent which constitutes the vast majority of the waste generated during peptide synthesis. In this work, propylene carbonate has been shown to be a green polar aprotic solvent which can be used to replace dichloromethane and DMF in both solution- and solid-phase peptide synthesis. Solution-phase chem. was carried out with Boc/benzyl (Boc = tert-butoxycarbonyl) protecting groups to the tetrapeptide stage, no epimerization occurred during these syntheses and chem. yields for both coupling and deprotection reactions in propylene carbonate were at least comparable to those obtained in conventional solvents. Solid-phase peptide synthesis was carried out using Fmoc (Fmoc = 9-fluorenylmethoxycarbonyl) protected amino acids on a ChemMatrix resin and was used to prepare the biol. relevant nonapeptide bradykinin with comparable purity to a sample prepared in DMF. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Category: benzofurans).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Comparative study of soluble soybean polysaccharides on bread staling under acidic conditions was written by Hong, Tingting;Wang, Lulu;Xu, Yue;Jin, Yamei;Xu, Dan;Wu, Fengfeng;Xu, Xueming. And the article was included in Food Chemistry in 2023.Electric Literature of C8H8O This article mentions the following:

Effect of soluble soybean polysaccharides (SSPS) and acidic condition on the bread staling of crumb and crust were evaluated in bread characteristics, water migration, starch retrogradation, and flavor. Bread characteristic anal. showed SSPS and acidic conditions significantly improved bread quality during storage, maintaining crumb softness. The staling rate of the synergistic group under SSPS and acidic condition decreased by 49.46% compared to the control group. This retardation was associated with water migration and starch retrogradation. SSPS and acidic conditions restricted the water migration from crumb to crust. A synergy between SSPS and acidification restrained the relative crystallinity and retrogradation enthalpy in bread crumbs and crust during storage. The scores plot and heat map anal. indicated SSPS and acidic condition was facilitated the flavors retention in the crumb and crust after stored 7-days. This study suggested SSPS and acidic conditions might be beneficial for extending bread shelf-life. In the experiment, the researchers used many compounds, for example, 2,3-Dihydrobenzo[b]furan (cas: 496-16-2Electric Literature of C8H8O).

2,3-Dihydrobenzo[b]furan (cas: 496-16-2) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C8H8O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hydrophobic constituents of Arnebia euchroma was written by Ye, Jia;Mu, Qing. And the article was included in Zhongyaocai in 2009.Product Details of 54120-64-8 This article mentions the following:

Massive hydrophobic constituents of Arnebia euchroma were investigated, and similarities and differences of AE and AEZ from different sources were compared. The hydrophobic constituents, AE01-1 and AEZ01-1, were obtained by chromatograph of silica gel with elution of chloroform used in the chloroform extracts of Arnebia euchroma, AE01 and AEZ01. GC-MS was used to identify the main components of the hydrophobic constituents. Eleven and 22 compounds were identified in the hydrophobic constituency, AE01-1 and AEZ01-1, including 5 common compounds that were the main components. AE01-1, the hydrophobic constituents of AE, had 2 naphthoquinones, while AEZ01-1, the hydrophobic constituents of AEZ, had only lipid compounds Compared with AE, AEZ has fewer naphthoquinones with low polarity. In the experiment, the researchers used many compounds, for example, 5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8Product Details of 54120-64-8).

5-Methylisobenzofuran-1(3H)-one (cas: 54120-64-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Product Details of 54120-64-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery was written by Zaiter, Samantha S.;Huo, Yuantao;Tiew, Fong Y.;Gestwicki, Jason E.;McAlpine, Shelli R.. And the article was included in Journal of Medicinal Chemistry in 2019.Quality Control of H-Arg(Pbf)-OH This article mentions the following:

Protein-protein interactions (PPIs) regulate all signaling pathways for cellular function. Developing mols. that modulate PPIs through the interface of their protein surfaces has been a significant challenge and there has been little success controlling PPIs through standard mol. library screening approaches. PPIs control the cell’s protein-folding machinery, and this machinery relies on a multi-protein complex formed with heat shock protein 70 (Hsp70). Described is the design, synthesis, and biol. evaluation of mols. aimed to regulate the interaction between two proteins that are critical to the protein-folding machinery: heat shock protein 70 (Hsp70) and cochaperone heat shock organizing protein (HOP). We report the first class of compounds that directly regulate these two protein-protein interactions and inhibit protein folding events. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Quality Control of H-Arg(Pbf)-OH).

H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Quality Control of H-Arg(Pbf)-OH

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

MCR-ALS with sample insertion constraint to enhance the sensitivity of surface-enhanced Raman scattering detection was written by Sricharoen, Nontawat;Sukmanee, Thanyada;Pienpinijtham, Prompong;Ekgasit, Sanong;Kitahama, Yasutaka;Ozaki, Yukihiro;Wongravee, Kanet. And the article was included in Analyst (Cambridge, United Kingdom) in 2021.Formula: C10H12O2 This article mentions the following:

The multivariate curve resolution-alternative least squares (MCR-ALS) algorithm was modified with sample insertion constraint to deconvolute the overlapping peaks in SERS spectra. The developed method was evaluated by the spectral data simulated using a Gaussian distribution function to generate two independent peaks corresponding to a capping agent and an analyte. The spectra were generated with different overlapping levels and various intensity ratios of the analyte to the capping agent. By using MCR-ALS with the sample insertion constraint, the peak of the capping agent was completely excluded to obtain a calibration model of the analyte with R² > 0.95 under all conditions. Furthermore, our developed method was later applied to a real SERS measurement to quantify carbofuran (analyte) using the azo-coupling reaction with p-ATP (capping agent) on silver nanoparticles as a SERS substrate. A calibration model of derivative carbofuran phenol was generated with R² = 0.99 and LOD = 28.19 ppm. To assess the performance of the calibration model, the model was used to estimate the concentration of carbofuran in an external validation set. It was found that the RMSE of prediction was only 2.109 with a promising R² = 0.97. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Formula: C10H12O2).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C10H12O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem