The greening of peptide synthesis was written by Lawrenson, Stefan B.;Arav, Roy;North, Michael. And the article was included in Green Chemistry in 2017.Category: benzofurans This article mentions the following:
The synthesis of peptides by amide bond formation between suitably protected amino acids is a fundamental part of the drug discovery process. However, the required coupling and deprotection reactions are routinely carried out in dichloromethane and DMF, both of which have serious toxicity concerns and generate waste solvent which constitutes the vast majority of the waste generated during peptide synthesis. In this work, propylene carbonate has been shown to be a green polar aprotic solvent which can be used to replace dichloromethane and DMF in both solution- and solid-phase peptide synthesis. Solution-phase chem. was carried out with Boc/benzyl (Boc = tert-butoxycarbonyl) protecting groups to the tetrapeptide stage, no epimerization occurred during these syntheses and chem. yields for both coupling and deprotection reactions in propylene carbonate were at least comparable to those obtained in conventional solvents. Solid-phase peptide synthesis was carried out using Fmoc (Fmoc = 9-fluorenylmethoxycarbonyl) protected amino acids on a ChemMatrix resin and was used to prepare the biol. relevant nonapeptide bradykinin with comparable purity to a sample prepared in DMF. In the experiment, the researchers used many compounds, for example, H-Arg(Pbf)-OH (cas: 200115-86-2Category: benzofurans).
H-Arg(Pbf)-OH (cas: 200115-86-2) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Category: benzofurans
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem