Day: February 22, 2023

Micro-hydrogel injectables that deliver effective CAR-T immunotherapy against 3D solid tumor spheroids was written by Suraiya, Anisha B.;Evtimov, Vera J.;Truong, Vinh X.;Boyd, Richard L.;Forsythe, John S.;Boyd, Nicholas R.. And the article was included in Translational Oncology in 2022.Product Details of 1461-15-0 This article mentions the following:

Chimeric antigen receptor (CAR-) T cells are revolutionizing cancer treatment, as a direct result of their clin. impact on the treatment of hematol. malignancies. However for solid tumors, CAR-T cell therapeutic efficacy remains limited, primarily due to the complex immunosuppressive tumor microenvironment, inefficient access to tumor cells and poor persistence of the killer cells. In this in vitro study, an injectable, gelatin-based micro-hydrogel system that can encapsulate and deliver effective CAR-T therapy is investigated. CAR-T cells targeting TAG-72, encapsulated in these microgels possessed high viability (> 87%) after 7 days, equivalent to those grown under normal expansion conditions, with retention of the T cell phenotype and functionality. Microgel recovered CAR-T cells demonstrated potent on-target cytotoxicity against human ovarian cancer in vitro and on three-dimensional tumor spheroids, by completely eliminating tumor cells. The gelatin-based micro-hydrogels have the potential to serve as carrier systems to augment CAR-T immunotherapeutic treatment of solid tumors. In the experiment, the researchers used many compounds, for example, 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0Product Details of 1461-15-0).

2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 1461-15-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Practical aspects in gas chromatography-mass spectrometry for the analysis of pesticide residues in exotic fruits was written by Espana Amortegui, Julio Cesar;Guerrero Dallos, Jairo Arturo. And the article was included in Food Chemistry in 2015.Synthetic Route of C10H12O2 This article mentions the following:

The most relevant parameters of a multimode inlet were optimized to increase the injection volume up to 25 μL using solvent vent mode in order to improve the sensitivity of the gas chromatog.-mass spectrometry system. Consequently, the implementation of a concurrent backflushing was necessary to largely prevent the expected loss of performance derived from such matrix load out of a general-purpose extraction (EN-15622-QuEChERS). Addnl., four mixtures of compounds used as analyte protectants were tested using spiked physalis to enhance the quality of signals. The chosen mixture remarkably improved sensitivity and yield better peak shapes, significantly more than others also tested. The anal. of pesticide residues in exotic fruits using instruments of limited selectivity is challenging since these complex matrixes usually give notably dirty extracts This scheme included an instrumental optimization and the addition of selected compounds that enabled to selectively reach limits of quantitation of 0.01 mg kg^-1 for most analytes. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Synthetic Route of C10H12O2).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C10H12O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aryl-Aryl Bond Formation by Flash Vacuum Pyrolysis of Benzannulated Thiopyrans was written by Amick, Aaron W.;Wakamiya, Atsushi;Scott, Lawrence T.. And the article was included in Journal of Organic Chemistry in 2008.Name: Naphtho[2,1-b]benzofuran This article mentions the following:

In contrast to fully unsaturated 7-membered ring sulfur heterocycles (thiepines), some of which extrude sulfur and give the ring-contracted hydrocarbon even at room temperature in solution, benzannulated thiopyrans (6-membered sulfur heterocycles) require flash vacuum pyrolysis (FVP) conditions in the gas phase at temperatures in the range of 1000-1200 °C to promote the corresponding reaction. Thus, FVP of benzo[kl]thioxanthene (1 = I) gives fluoranthene, and naphtho[2,1,8,7-klmn]thioxanthene (6 = VI) gives benzo[ghi]fluoranthene (7 = VII). FVP of thioxanthone gives fluorenone together with lesser amounts of dibenzo[b,d]thiophene from competing decarbonylation. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Name: Naphtho[2,1-b]benzofuran).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Name: Naphtho[2,1-b]benzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization and biological activities of some benzofuropyrimidine derivatives was written by Yamuna, A. J.;Vaidya, Vijayvithal P.;Shruthi, Eshwarappa;Mahadevan, Kittappa M.. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2013.COA of Formula: C11H10BrNO3 This article mentions the following:

A series of new benzofuropyrimidinone derivatives I [Ar = C₆H₅, 2-ClC₆H₄, 4-ClC₆H₄, etc.; R = H, Me] were synthesized by using Et 3-amino-5-bromo-benzofuran-2-carboxylate (II) as a starting material. Amino ester II was converted into its hydrazide by reacting with hydrazine hydrate, which upon treatment with various aldehydes and ketones gave corresponding Schiff bases III [Ar = C₆H₅, 2-ClC₆H₄, 4-ClC₆H₄, etc.; R = H, Me]. The desired compounds I were obtained by reacting Schiff bases III with tri-Et orthoformate. The compounds I were evaluated for their antimicrobial activity by cup plate method and antioxidant activity by DPPH radical scavenging method. Some of the compounds exhibited considerable antimicrobial activities and compounds I [R = 4-MeOC₆H₄, 4-HOC₆H₄] were found to be excellent in scavenging DPPH radical at 50 μg and also retained almost same activity in 100 μg. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-5-bromobenzofuran-2-carboxylate (cas: 330555-71-0COA of Formula: C11H10BrNO3).

Ethyl 3-amino-5-bromobenzofuran-2-carboxylate (cas: 330555-71-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C11H10BrNO3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reducing synthetic colorants release from alginate-based liquid-core beads with a zein shell was written by Liu, Hongxiang;Chiou, Bor-Sen;Ma, Yun;Corke, Harold;Liu, Fei. And the article was included in Food Chemistry in 2022.Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) This article mentions the following:

An innovative method to reduce hydrophilic synthetic colorant release at interface was presented in this work, based on the anti-solvent effect at the membrane outside surface of liquid-core beads manufactured by reverse spherification between alginate and calcium ion. Zein, a hydrophobic protein which formed precipitation shell ensured the stability of colorant. Acidification of solvent made zein particles more kinetically stable, allowed zein stretching and collated more orderly secondary structures even in high polarity solvents. Colorants that hydrogen bonded or electrostatically interacted with zein could have optimized release properties. The zein/erythrosine samples had the most orderly secondary structure from CD and had the highest stability among all zein/colorant systems. The release rate of erythrosine was only 2.76% after 48 h storage after soaking in zein shell solution This study demonstrated a promising clean and scalable strategy to encapsulate hydrophilic compounds in zein-based shells of liquid-core beads for food, supplement and pharmaceutical applications. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Unprecedented Diastereoselective Arylogous Michael Addition of Unactivated Phthalides was written by Sicignano, Marina;Schettini, Rosaria;Sica, Luisa;Pierri, Giovanni;De Riccardis, Francesco;Izzo, Irene;Maity, Bholanath;Minenkov, Yury;Cavallo, Luigi;Della Sala, Giorgio. And the article was included in Chemistry – A European Journal in 2019.HPLC of Formula: 4741-62-2 This article mentions the following:

The first highly enantioselective arylogous Michael reaction (AMR) of 3-unsubstituted phthalides was described. This phase-transfer methodol., which uses catalytic amounts of KOH/18-crown-6 catalyst in mesitylene in the presence of N,O-bis(trimethylsilyl)acetamide (BSA), gives access to a broad range of 3-monosubstituted phthalides with high levels of syn diastereoselectivity and good yields, starting from 3-unsubstituted derivatives and diverse α,β-unsaturated carbonyl compounds The reaction also applied to unactivated 3-alkyl phthalides to afford 3,3-dialkyl derivatives A plausible mechanism was suggested. DFT anal. of possible transition states gives a rationale of the high syn diastereoselectivity observed and its correlation with the solvent’s dielec. constant In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2HPLC of Formula: 4741-62-2).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.HPLC of Formula: 4741-62-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Phytotoxic Allelochemicals from Roots and Root Exudates of Trifolium pratense was written by Liu, Quan;Xu, Rui;Yan, Zhiqiang;Jin, Hui;Cui, Haiyan;Lu, Liqin;Zhang, Denghong;Qin, Bo. And the article was included in Journal of Agricultural and Food Chemistry in 2013.Application In Synthesis of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol This article mentions the following:

Trifolium pratense, a widespread legume forage plant, is reported to exhibit phytotoxic activity on other plants, but the active metabolites have not been clarified so far. A bioassay-guided fractionation of the root extracts led to the isolation of five isoflavonoids, which were elucidated by spectroscopic anal. All of the purified compounds observably showed phytotoxic activities against Arabidopsis thaliana. Moreover, the inhibitory effects were concentration-dependent. The furan ring linked at C-4 and C-2′ positions by an oxygen atom and a 1,3-dioxolane at C-4′ and C-5′ positions are considered to be critical factors for the phytotoxic activity. The concentrations of (6aR,11aR)-maackiain and (6aR,11aR)-trifolirhizin, concluded to be allelochems. from soil around plants of T. pratense, were determined by HPLC and LC-MS to be 4.12 and 2.37 μg/g, resp. These allelochems., which showed remarkable activities against the weed Poa annua may play an important role in assisting the widespread occurrence of T. pratense in nature. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Application In Synthesis of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application In Synthesis of (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Decarboxylative tandem C-N coupling with nitroarenes via S_H2 mechanism was written by Wang, Shuaishuai;Li, Tingrui;Gu, Chengyihan;Han, Jie;Zhao, Chuan-Gang;Zhu, Chengjian;Tan, Hairen;Xie, Jin. And the article was included in Nature Communications in 2022.Recommanded Product: 17403-47-3 This article mentions the following:

In this paper, a radical tandem C-N coupling strategy to efficiently construct aromatic tertiary amines from com. available carboxylic acids and nitroarenes was developed. A variety of aromatic tertiary amines were furnished in good yields (up to 98%) with excellent functional group compatibility under mild reaction conditions. The use of two different carboxylic acids also allowed for the concise synthesis of nonsym. aromatic tertiary amines in satisfactory yields. Mechanistic studies suggested the intermediacy of the arylamine-(TPP)Fe(III) species and might provide a possible evidence for an S_H2 (bimol. homolytic substitution) pathway in the critical C-N bond formation step. In the experiment, the researchers used many compounds, for example, 5-Nitro-2,3-dihydrobenzofuran (cas: 17403-47-3Recommanded Product: 17403-47-3).

5-Nitro-2,3-dihydrobenzofuran (cas: 17403-47-3) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 17403-47-3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Composition and structure characterization of coker gas oils derived from FCC decant oil before and after hydrotreating was written by Cai, Xinheng;Liu, Yingrong;Liu, Zelong;Fan, Qiming;Tian, Songbai. And the article was included in Shiyou Xuebao, Shiyou Jiagong in 2014.SDS of cas: 205-39-0 This article mentions the following:

Coker gas oils derived from FCC decant oil before and after hydrotreating were characterized by GC-FID/MS and NMR. A total of 121 aromatic compounds in the coke gas oils were identified and quantitated, including polycyclic aromatic hydrocarbons (PAHs), hydrogenated PAHs, C0-C2 substituted PAHs, thiophenic compounds and carbazoles. The compositional and structural changes in process of hydrotreating-delayed coking of FCC decant oil were also investigated. Coker gas oils derived from FCC decant oils with and without hydrotreating had different compound compositions, though their hydrocarbon group composition were quite similar. The gas oil from hydrotreated FCC decant oil had less unsubstituted polycyclic aromatic and heteroaromatic hydrocarbons, while more alkyl substituted aromatics and naphthenic-aromatics than that from the unhydrotreated one, implying that hydrotreating is beneficial for enhancing cracking and condensation reactions and improving liquid products in delayed coking of FCC decant oil. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0SDS of cas: 205-39-0).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.SDS of cas: 205-39-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biocompatible Amphiphilic Hydrogel-Solid Dimer Particles as Colloidal Surfactants was written by Chen, Dong;Amstad, Esther;Zhao, Chun-Xia;Cai, Liheng;Fan, Jing;Chen, Qiushui;Hai, Mingtan;Koehler, Stephan;Zhang, Huidan;Liang, Fuxin;Yang, Zhenzhong;Weitz, David A.. And the article was included in ACS Nano in 2017.Electric Literature of C20H13NO5 This article mentions the following:

Emulsions of two immiscible liquids can slowly coalesce over time when stabilized by surfactant mols. Pickering emulsions stabilized by colloidal particles can be much more stable. Here, we fabricate biocompatible amphiphilic dimer particles using a hydrogel, a strongly hydrophilic material, and achieve large contrast in the wetting properties of the two bulbs, resulting in enhanced stabilization of emulsions. We generate monodisperse single emulsions of alginate and shellac solution in oil using a flow-focusing microfluidics device. Shellac precipitates from water and forms a solid bulb at the periphery of the droplet when the emulsion is exposed to acid. Mol. interactions result in amphiphilic dimer particles that consist of two joined bulbs: one hydrogel bulb of alginate in water and the other hydrophobic bulb of shellac. Alginate in the hydrogel compartment can be cross-linked using calcium cations to obtain stable particles. Analogous to surfactant mols. at the interface, the resultant amphiphilic particles stand at the water/oil interface with the hydrogel bulb submerged in water and the hydrophobic bulb in oil and are thus able to stabilize both water-in-oil and oil-in-water emulsions, making these amphiphilic hydrogel-solid particles ideal colloidal surfactants for various applications. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Electric Literature of C20H13NO5).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Electric Literature of C20H13NO5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem