Unprecedented Diastereoselective Arylogous Michael Addition of Unactivated Phthalides was written by Sicignano, Marina;Schettini, Rosaria;Sica, Luisa;Pierri, Giovanni;De Riccardis, Francesco;Izzo, Irene;Maity, Bholanath;Minenkov, Yury;Cavallo, Luigi;Della Sala, Giorgio. And the article was included in Chemistry – A European Journal in 2019.HPLC of Formula: 4741-62-2 This article mentions the following:
The first highly enantioselective arylogous Michael reaction (AMR) of 3-unsubstituted phthalides was described. This phase-transfer methodol., which uses catalytic amounts of KOH/18-crown-6 catalyst in mesitylene in the presence of N,O-bis(trimethylsilyl)acetamide (BSA), gives access to a broad range of 3-monosubstituted phthalides with high levels of syn diastereoselectivity and good yields, starting from 3-unsubstituted derivatives and diverse α,β-unsaturated carbonyl compounds The reaction also applied to unactivated 3-alkyl phthalides to afford 3,3-dialkyl derivatives A plausible mechanism was suggested. DFT anal. of possible transition states gives a rationale of the high syn diastereoselectivity observed and its correlation with the solvent’s dielec. constant In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2HPLC of Formula: 4741-62-2).
5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.HPLC of Formula: 4741-62-2
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem