Day: October 28, 2021

Recently I am researching about N-HETEROCYCLIC CARBENE; EFFICIENT CATALYSTS; BASIS-SETS; SELECTIVE HYDROGENATION; MOLECULAR CALCULATIONS; CARBOXYLIC ESTERS; COMPLEXES; ALCOHOLS; REDUCTION; ACID, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE-1665144, CHE-1726308]. Safety of Isobenzofuran-1(3H)-one. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Le, L; Liu, JC; He, TY; Malek, JC; Cervarich, TN; Buttner, JC; Pham, J; Keith, JM; Chianese, AR. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

We report the conversion of a series of CNN-pincer-ruthenium complexes Ru(CNN)HCl(CO) to a CC-chelated form Ru(CC)(PR3)(2)H(CO) on reaction with sodium tert-butoxide and monodentate phosphines. When the phosphine is triphenylphosphine, cis-phosphine complexes form at room temperature, which convert to the trans isomer at elevated temperatures. When the phosphine is tricyclohexylphosphine, only the trans-phosphine isomer is observed. The CC-chelated complexes are active catalysts for the hydrogenation of esters, without the need for added base. The ligand structure-activity relationship in the series of CC-chelated complexes mirrors that in the precursor CNN-Ru complexes, potentially indicating a common catalytic mechanism. Density functional theory calculations establish a plausible mechanism for the CNN-to-CC rearrangement and demonstrate that this rearrangement is potentially reversible under the conditions of ester hydrogenation catalysis.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Le, L; Liu, JC; He, TY; Malek, JC; Cervarich, TN; Buttner, JC; Pham, J; Keith, JM; Chianese, AR or concate me.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-kappa B expression WOS:000477804500086 published article about TRADITIONAL CHINESE MEDICINE; CORONARY-HEART-DISEASE; UP-REGULATION; ATHEROGENESIS; CHOLESTEROL; ACTIVATION; MACROPHAGE in [Lei, Wei; Deng, Yan-Fang; Hu, Xue-Yan; Jiang, Min; Bai, Gang] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China; [Lei, Wei; Deng, Yan-Fang; Hu, Xue-Yan; Jiang, Min; Bai, Gang] Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China; [Ni, Jia-Nan] Tianjing Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China in 2019, Cited 36. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

Atherosclerosis is initiated by the local inflammation response to lipid deposition, and the most commonly administered antiatherogenic drugs are statins. Based on traditional Chinese medicine (TCM) evidence, we aimed to find effective therapeutic agents other than statins. A TCM, Suxiao Jiuxin Pill (SX), has been widely used in curing cardiovascular diseases for thirty years. In this paper, a combination of pharmacologic studies and RNA-Seq transcriptomics were employed to explore the pharmacodynamic advantages of SX over atorvastatin in the ApoE(-/-) mouse. 113 differentially expressed genes that were modulated by SX to a greater degree than atorvastatin were primarily involved in immunomodulation. The expression of BTK, AKT1, c-jun and CD137 was effectively regulated by SX with better effect than atorvastatin. Then a dual-luciferase reporter assay for NF-kappa B inhibition was applied to identify active components in SX. As a result, Senkyunolide A (Sen A) and Ligustilide (Lig), the key immunomodulatory ingredients in SX, were found to inhibit the expression of CD137 which is a diagnostic biomarker in atherosclerosis. It was further confirmed that Lig effectively suppressed the expression of AP-1 and NF-kappa B and the phosphorylation of AKT. Therefore, Lig achieved its CD137 inhibition through suppressing the expression of AP-1 and AKT/NF-kappa B signaling pathway, which partly explains the immunomodulation of SX in atherosclerosis. Above all, phthalides may be the primary components of SX improving immune and inflammation response in atherosclerosis.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lei, W; Deng, YF; Hu, XY; Ni, JN; Jiang, M; Bai, G or concate me.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Application In Synthesis of Isobenzofuran-1(3H)-one. Stecoza, CE; Draghici, C; Caproiu, MT; Pircalabioru, GG; Marutescu, L in [Stecoza, Camelia Elena] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Chem, 6 Traian Vuia St, Bucharest 020956, Romania; [Draghici, Constantin; Caproiu, Miron Teodor] Costin D Nenitescu Ctr Organ Chem Romanian Acad, 202 B Splaiul Independentei, Bucharest 060023, Romania; [Pircalabioru, Gratiela Gradisteanu; Marutescu, Luminita] Univ Bucharest, Res Inst, Bucharest 60101, Romania published SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF NOVEL DIBENZOTHIEPINES in 2020, Cited 21. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Considering the anti-infective potential of compounds containing the dibenzothiepine scaffold, we set out to obtain new compounds bearing this structure. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their microbiostatic/microbicidal and antibiofilm properties against reference and clinical microbial strains. The new compounds exhibited a broad spectrum of antimicrobial activity, which was more intensive for the S-oxidized compounds. Some of the compounds also inhibited the ability of the investigated strains to form biofilms on the inert substratum.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Stecoza, CE; Draghici, C; Caproiu, MT; Pircalabioru, GG; Marutescu, L or concate me.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Geng, PX; Tang, YR; Pan, GT; Wang, WT; Hu, JC; Cai, YF in ROYAL SOC CHEMISTRY published article about GRAPHITIC CARBON NITRIDE; PHOTOREDOX CATALYSIS; ALPHA-OXYGENATION; MOLECULAR-OXYGEN; SINGLET OXYGEN; BOND-CLEAVAGE; OXIDATION; ETHERS; COPPER; EFFICIENT in [Geng, Pengxin; Hu, Jinchuan] Chongqing Normal Univ, Coll Chem, Chongqing 401331, Peoples R China; [Geng, Pengxin; Tang, Yurong; Pan, Guangtong; Cai, Yunfei] Chongqing Univ, Sch Chem & Chem Engn, 174 Shazheng St, Chongqing 400030, Peoples R China; [Geng, Pengxin; Tang, Yurong; Pan, Guangtong; Cai, Yunfei] Chongqing Univ, Chongqing Key Lab Theoret & Computat Chem, 174 Shazheng St, Chongqing 400030, Peoples R China; [Wang, Wentao] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China in 2019, Cited 80. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C3N4) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biologically valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this green methodology was further demonstrated by applying in bioactive and drug valued target syntheses.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Geng, PX; Tang, YR; Pan, GT; Wang, WT; Hu, JC; Cai, YF or concate me.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Tunable pH-sensitive 2-carboxybenzyl phosphoramidate cleavable linkers published in 2020. Computed Properties of C8H6O2, Reprint Addresses Berkman, CE (corresponding author), Washington State Univ, Dept Chem, Pullman, WA 99164 USA.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pK(a) of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pK(a) of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values. (C) 2020 Elsevier Ltd. All rights reserved.

Computed Properties of C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article EXPLORATION OF MODERATE CONDITIONS AND SUBSTRATE VARIATION IN THE DIRECT CONDENSATION BETWEEN PHTHALIDE AND PRIMARY AMINE CATALYZED BY GaCl3. ARE ALIPHATIC AMINES LESS REACTIVE THAN AROMATIC ONES? WOS:000474679300017 published article about CONDITION PHTHALIMIDINE SYNTHESIS; DUAL SYNTHETIC AUXILIARIES; 1,2,3-1H-BENZOTRIAZOLE; 2-MERCAPTOETHANOL; ISOINDOLINONES; MECHANISM in [Takahashi, Ichiro; Nishiwaki, Yoshinori; Saitoh, Kenta; Matsunaga, Takatoshi; Aratake, Akihiro; Morita, Toshio] Univ Fukui, Fac Engn, Dept Appl Chem & Biotechnol, Bunkyo Ku, Fukui 9108507, Japan; [Hosoi, Shinzo] Kyoto Pharmaceut Univ, Res Ctr Pharm Educ, Yamashina Ku, 5 Nakauchi Cho, Kyoto 6078414, Japan in 2019, Cited 38. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Quality Control of Isobenzofuran-1(3H)-one

Direct condensation between phthalide and a primary amine in the presence of Lewis acid was achieved for the first time in organic solvent-diluted reaction systems catalyzed by GaCl3. The peripheral aspects of this reaction is discussed.

Quality Control of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Takahashi, I; Nishiwaki, Y; Saitoh, K; Matsunaga, T; Aratake, A; Morita, T; Hosoi, S or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. Recently I am researching about MASS-SPECTROMETRY; FATTY-ACIDS; A-D; LIQUID-CHROMATOGRAPHY; KINASE INHIBITOR; FRUITING BODY; IDENTIFICATION; ANTIOXIDANT; HANABIRATAKE; METABOLITES, Saw an article supported by the Key Projects of Scientific Research Program of Beijing Municipal Commission of Education [KZ201811417049]. Published in MDPI in BASEL ,Authors: Wang, ZX; Liu, JY; Zhong, XJ; Li, JJ; Wang, X; Ji, LL; Shang, XY. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Sparassis crispa is a kind of edible fungus widely grows in the north temperate zone, which shows various medicinal properties. Due to the complexity of chemical constitutes of this species, few investigations have acquired a comprehensive configuration for the chemical profile of it. In this study, a strategy based on ultra-high performance liquid chromatography (UPLC) combined with Orbitrap mass spectrometer (MS) was established for rapidly characterizing various chemical components in S. crispa. Through the summarized MS/MS fragmentation patterns of reference compounds and systematic identification strategy, a total of 110 components attributed to six categories were identified for the first time. Moreover, allergic rhinitis (AR) is a worldwide inflammatory disease seriously affecting human health, and the development of drugs to treat AR has been a topic of interest. It has been reported that the extracts of S. crispa showed obvious inhibitory effects on degranulation of mast cell- and allergen-induced IgE and proinflammatory mediators, but the active components and specific mechanism were still not clear. Src family kinases (SFKs) participate in the initial stage of allergy occurrence, which are considered the targets of AR treatment. Herein, on the basis of that self-built chemical database, virtual screening was applied to predict the potential SFKs inhibitors in S. crispa, using known crystal structures of Hck, Lyn, Fyn, and Syk as receptors, followed by the anti-inflammatory activity evaluation for screened hits by intracellular calcium mobilization assay. As results, sparoside A was directly confirmed to have strong anti-inflammatory activity with an IC50 value of 5.06 +/- 0.60 mu M. This study provides a useful elucidation for the chemical composition of S. crispa, and demonstrated its potential inhibitory effects on AR, which could promote the research and development of effective agents from natural resources.

Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, ZX; Liu, JY; Zhong, XJ; Li, JJ; Wang, X; Ji, LL; Shang, XY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. Le, L; Liu, JC; He, TY; Malek, JC; Cervarich, TN; Buttner, JC; Pham, J; Keith, JM; Chianese, AR in [Linh Le; Liu, Jiachen; He, Tianyi; Malek, Jack C.; Cervarich, Tia N.; Buttner, John C.; Pham, John; Keith, Jason M.; Chianese, Anthony R.] Colgate Univ, Dept Chem, 13 Oak Dr, Hamilton, NY 13346 USA published Unexpected CNN-to-CC Ligand Rearrangement in Pincer-Ruthenium Precatalysts Leads to a Base-Free Catalyst for Ester Hydrogenation in 2019, Cited 68. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

We report the conversion of a series of CNN-pincer-ruthenium complexes Ru(CNN)HCl(CO) to a CC-chelated form Ru(CC)(PR3)(2)H(CO) on reaction with sodium tert-butoxide and monodentate phosphines. When the phosphine is triphenylphosphine, cis-phosphine complexes form at room temperature, which convert to the trans isomer at elevated temperatures. When the phosphine is tricyclohexylphosphine, only the trans-phosphine isomer is observed. The CC-chelated complexes are active catalysts for the hydrogenation of esters, without the need for added base. The ligand structure-activity relationship in the series of CC-chelated complexes mirrors that in the precursor CNN-Ru complexes, potentially indicating a common catalytic mechanism. Density functional theory calculations establish a plausible mechanism for the CNN-to-CC rearrangement and demonstrate that this rearrangement is potentially reversible under the conditions of ester hydrogenation catalysis.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Le, L; Liu, JC; He, TY; Malek, JC; Cervarich, TN; Buttner, JC; Pham, J; Keith, JM; Chianese, AR or concate me.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Lukic, I; Carlin, S; Horvat, I; Vrhovsek, U in [Lukic, Igor; Horvat, Ivana] Inst Agr & Tourism, K Huguesa 8, Porec 52440, Croatia; [Lukic, Igor] Ctr Excellence Biodivers & Mol Plant Breeding, Svetosimunska 25, Zagreb 10000, Croatia; [Carlin, Silvia; Vrhovsek, Urska] Fdn Edmund Mach FEM, Res & Innovat Ctr, Dept Food Qual & Nutr, Via E Mach 1, I-38010 San Michele All Adige, TN, Italy; [Carlin, Silvia] Univ Udine, Dept Agr Food Environm & Anim Sci, Via Sci 208, I-33100 Udine, Italy published Combined targeted and untargeted profiling of volatile aroma compounds with comprehensive two-dimensional gas chromatography for differentiation of virgin olive oils according to variety and geographical origin in 2019, Cited 35. Quality Control of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC x GC-TOF-MS) was combined with conventional mono-dimensional GC-MS to differentiate Croatian virgin olive oils (VOO) according to variety and geographical origin, based on the profile of volatile aroma compounds isolated by HS-SPME. More than 1000 compounds were detected after untargeted profiling and 256 were identified or tentatively identified, providing one of the most detailed profiles of volatile aroma compounds in VOO up to date. Among them, 131 volatile compounds were significantly different across monovarietal VOOs, while 60 were found useful for the discrimination according to geographical origin. Many major lipoxygenase and minor non-lipoxygenase-generated compounds were shown to have discriminating ability with respect to both factors. Multivariate statistical analysis extracted twenty-one volatile markers with the highest discriminant power for varietal differentiation. The approach reported may have practical application in better understanding, defining, managing, and communicating the varietal or geographical typicity of monovarietal VOOs.

Quality Control of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lukic, I; Carlin, S; Horvat, I; Vrhovsek, U or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Lv, F; Xiao, J; Xiang, JC; Guo, FZ; Tang, ZL; Han, LB in [Lv, Fang; Xiao, Jing; Xiang, Junchun; Guo, Fengzhe; Tang, Zi-Long] Hunan Univ Sci & Technol, Minist Educ, Key Lab Theoret Organ Chem & Funct Mol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China; [Han, Li-Biao] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058565, Japan published Conversion of Aryl Aldehydes to Benzyl Iodides and Diarylmethanes by H3PO3/I-2 in 2021, Cited 61. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

For the first time, H3PO3 was used as both the reducing reagent and the promotor in the reductive benzylation reactions with aryl aldehydes. By using a H3PO3/I-2 combination, various aromatic aldehydes underwent iodination reactions and Friedel-Crafts type reactions with arenes via benzyl iodide intermediates, readily producing benzyl iodides and diarylmethanes in good yields. Intramolecular cyclization reactions also took place, giving the corresponding cyclic compounds. This new strategy features easy-handling, low-cost, and metal-free conditions.

SDS of cas: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lv, F; Xiao, J; Xiang, JC; Guo, FZ; Tang, ZL; Han, LB or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem