Day: October 12, 2021

Name: Isobenzofuran-1(3H)-one. Recently I am researching about AEROBIC OXIDATION; SELECTIVE OXIDATION; ETHERS; COPPER; ISOCOUMARINS; PHTHALIDES; ALKANES, Saw an article supported by the Science and Engineering Research Board (SERB), New Delhi [EEQ/2016/000203]; SERB, New DelhiDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India [PDF/2016/002733]; UGC, New DelhiUniversity Grants Commission, India [PDF/2016/002733]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Thatikonda, T; Deepake, SK; Kumar, P; Das, U. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A metal-free organocatalytic system has been developed for highly efficient benzylic C-H oxygenations of cyclic ethers using oxygen as an oxidant. This oxidation reaction utilizes alpha-angelica lactone as a low cost/low molecular weight catalyst. The optimized reaction conditions allow the synthesis of valued isocoumarins and phthalides from readily available precursors in good yields. Mechanistic studies indicate that the reaction pathway likely involves a radical process via a peroxide intermediate.

Name: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Thatikonda, T; Deepake, SK; Kumar, P; Das, U or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation WOS:000580634600039 published article about PATHWAY CONTRIBUTES; STROKE; INJURY; NEUROGENESIS; LIGUSTILIDE; DEFICITS; KLOTHO in [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, West China Sch Pharm,Dept Pharmacol,Sichuan Engn, Chengdu 610041, Peoples R China; [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Sichuan Prov Key Lab Qual & Innovat Res Chinese M, Chengdu 610041, Peoples R China; [Duan, Wei] Deakin Univ, Sch Med, Waurn Ponds, Vic, Australia; [Duan, Wei] Deakin Univ, Ctr Mol & Med Res, Waurn Ponds, Vic, Australia; [Yang, Yu-Xin] PRIVIS TECHNOL CO LTD, Chengdu 610041, Peoples R China in 2020, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Name: Isobenzofuran-1(3H)-one

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the underlying mechanisms. Transient middle cerebral artery occlusion (tMCAO) was used as a mouse model of ischemic stroke, while BV2 cells stimulated with conditioned medium collected from oxygen-glucose deprivation-treated HT22 cells were used in in vitro ischemic studies. The current results showed that CD21 dose-dependently and significantly improved neurological outcomes in tMCAO mice. Biochemical analyses revealed that CD21 decreased the expression of M1 phenotype markers (CD86, interleukin-1 beta and inducible nitric oxide synthase) and increased the expression of M2 phenotype markers (CD206, interleukin-10 and YM1/2) in both ischemic brain tissues and BV2 cells. Meanwhile, CD21 decreased the production of proinflammatory cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha), promoted the release of the antiinflammatory cytokine (interleukin-10), and enhanced the phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) in ischemic brain tissue and BV2 cells. Furthermore, the AMPK inhibitor (compound C) reversed these effects of CD21 in BV2 cells. These findings indicate that CD21 alleviates post-ischemic neuroinflammation through induction of microglial M2 polarization that is at least in part medicated by AMPK activation, suggesting that CD21 may be a promising candidate for protecting against ischemic brain injury.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR or concate me.. Name: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 DALTON T published article about SOLVENT-FREE HYDROBORATION; CYCLIC CARBONATES; TRANSFER HYDROGENATION; SELECTIVE REDUCTION; COMPLEXES SYNTHESES; METHANOL; CO2; DERIVATIVES; REACTIVITY; ALDEHYDES in [Cao, Xu; Wang, Weifan; Lu, Kai; Xue, Fei; Ma, Mengtao] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Peoples R China; [Yao, Weiwei] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China in 2020, Cited 55. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

A low-valent magnesium(i) complex [((Xyl)Nacnac)Mg](2) was employed as a highly efficient precatalyst for the hydroboration of a variety of cyclic and linear organic carbonates, polycarbonates, CO2 and esters with HBpin under mild conditions. The resultant boronates can be used for the preparation of the corresponding value-added diols, triols or alcohols through hydrolysis.

HPLC of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Cao, X; Wang, WF; Lu, K; Yao, WW; Xue, F; Ma, MT or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 RES CHEM INTERMEDIAT published article about BIOLOGICAL EVALUATION; DERIVATIVES; HYDRAZONES; DESIGN in [Alifu, Zulipiye; Nizhamu, Maijidan; Ablajan, Keyume] Xinjiang Univ, Key Lab Oil & Gas Fine Chem, Minist Educ & Xinjiang Uyghur Autonomous Reg, Coll Chem & Chem Engn, Urumqi 830046, Peoples R China in 2019, Cited 22. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Quality Control of Isobenzofuran-1(3H)-one

We report an efficient, catalyst-free, one-pot synthesis of (E)-N ‘-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives by the one-pot reaction of phthalide, hydrazine hydrate and aldehyde. Advantages of this synthetic approach include mild reaction conditions and environmentally friendly nature, and the ability to provide a wide range of desired compounds in moderate to excellent yields. Graphic abstract Here we introduce a green and efficient one-pot three-component protocol for the synthesis of (E)-N ‘-benzylidene-2-(hydroxymethyl)benzohydrazide derivatives in ethanol without any catalyst. [GRAPHICS] .

Quality Control of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Alifu, Z; Nizhamu, M; Ablajan, K or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Unexpected CNN-to-CC Ligand Rearrangement in Pincer-Ruthenium Precatalysts Leads to a Base-Free Catalyst for Ester Hydrogenation WOS:000485211100009 published article about N-HETEROCYCLIC CARBENE; EFFICIENT CATALYSTS; BASIS-SETS; SELECTIVE HYDROGENATION; MOLECULAR CALCULATIONS; CARBOXYLIC ESTERS; COMPLEXES; ALCOHOLS; REDUCTION; ACID in [Linh Le; Liu, Jiachen; He, Tianyi; Malek, Jack C.; Cervarich, Tia N.; Buttner, John C.; Pham, John; Keith, Jason M.; Chianese, Anthony R.] Colgate Univ, Dept Chem, 13 Oak Dr, Hamilton, NY 13346 USA in 2019, Cited 68. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: Isobenzofuran-1(3H)-one

We report the conversion of a series of CNN-pincer-ruthenium complexes Ru(CNN)HCl(CO) to a CC-chelated form Ru(CC)(PR3)(2)H(CO) on reaction with sodium tert-butoxide and monodentate phosphines. When the phosphine is triphenylphosphine, cis-phosphine complexes form at room temperature, which convert to the trans isomer at elevated temperatures. When the phosphine is tricyclohexylphosphine, only the trans-phosphine isomer is observed. The CC-chelated complexes are active catalysts for the hydrogenation of esters, without the need for added base. The ligand structure-activity relationship in the series of CC-chelated complexes mirrors that in the precursor CNN-Ru complexes, potentially indicating a common catalytic mechanism. Density functional theory calculations establish a plausible mechanism for the CNN-to-CC rearrangement and demonstrate that this rearrangement is potentially reversible under the conditions of ester hydrogenation catalysis.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Le, L; Liu, JC; He, TY; Malek, JC; Cervarich, TN; Buttner, JC; Pham, J; Keith, JM; Chianese, AR or concate me.. Recommanded Product: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems published in 2019. COA of Formula: C8H6O2, Reprint Addresses Dong, SL (corresponding author), Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China.; Dong, SL (corresponding author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The specific detection of cysteine (Cys) over homocysteine (Hcy), glutathione (GSH) and other amino acids is of great significance for studying its biological functions as well as for the diagnosis of related diseases. Chloroacetyl group was often used as a reaction site for cysteine fluorescent probes for its sensitivity and selectivity. However, high background fluorescence and low stability are common problems encountered by such probes. Here, four chloroacetyl group based fluorescent probes (C1, C2, C3, and H4) was synthesized for a comparative study. We found that the inefficient quenching ability of chloroacetyl group turned into an advantage when connected with a ratiometric fluorophore. With the modification of chloroacetyl group, probe H4 displayed excellent ratiometric property and great selectivity for Cys, the stability was also improved. Additionally, the probe was successfully applied for quantitative detection of Cys in fetal bovine serum and real-time imaging in living HeLa cells with low toxicity. (C) 2019 Elsevier Ltd. All rights reserved.

COA of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Liu, ZK; Wang, QQ; Wang, H; Su, WT; Dong, SL or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Science & Technology – Other Topics; Engineering; Environmental Sciences & Ecology very interesting. Saw the article Degradation of alpha-nitroso-beta-naphthol by UVA-B activated peroxide, persulfate and monopersulfate oxidants in water published in 2019. SDS of cas: 87-41-2, Reprint Addresses Yao, J (corresponding author), China Univ Geosci Beijing, Res Ctr Environm Sci & Engn, Sch Water Resource & Environm, 29 Xueyuan Rd, Beijing 100083, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Flotation reagents, especially new chelating agents represented by alpha-nitroso-beta-naphthol, are the main components of cobalt mining drainage. This study reports the degradation of alpha-nitroso-beta-naphthol by simulated UVA-B (280-400 nm) activated systems using three common oxidants, hydrogen peroxide, sodium persulfate and potassium monopersulfate at a laboratory scale using a photoreactor. Parameters which can affect the degradation process were investigated and comparison of the degradation performance of the three systems were made. Based on the results, UVA-B/sodium persulfate system exhibited best performance towards the removal of alpha-nitroso-beta-naphthol with a lower cost of oxidant and energy consumption compared to the others. The removal efficiency was found to increase as the oxidant dosage and the UVA-B power increases. Only potassium monopersulfate could be activated by bicarbonate and chloride ions, and SO42- has insignificant effect on the removal efficiency of alpha-nitroso-beta-naphthol for all systems while NO3- inhibited the degradation of alpha-nitroso-beta-naphthol. In the UVA-B/hydrogen peroxide system, the hydroxyl radical had a leading role in the degradation of alpha-nitroso-beta-naphthol, while in the other two systems, the degradation of alpha-nitroso-beta-naphthol was mainly caused by the hydroxyl and sulphate radicals. Ten major intermediates from alpha-nitroso-beta-naphthol degradation in the three oxidation systems were identified by gas chromatography and mass spectrometry. In summary, this report could be a great input in developing UVA-B activated oxidants-based treatment technologies. The UVA-B/sodium persulfate system is strongly recommended for its consideration in the treatment of mine impacted wastewaters. (c) 2019 Elsevier Ltd. All rights reserved.

SDS of cas: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lu, C; Yao, J; Knudsen, TS; Amde, M; Gu, JH; Liu, JL; Li, H; Zhang, JY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. Renzetti, A; Fukumoto, K in [Renzetti, Andrea; Fukumoto, Kozo] Univ Ryukyus, Fac Educ, 1 Senbaru, Nishihara, Okinawa 9030213, Japan published Synthesis of Phthalides and alpha,beta-butenolides by Transition Metal-Catalyzed Activation of CH Bonds in 2019, Cited 68. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Phthalides and ,-butenolides are two related classes of oxygenated heterocycles with a wide range of biological activities. An innovative strategy to prepare these compounds is based on CH bond functionalization reactions, in which two simple, unfunctionalized molecules are coupled together with cleavage of a CH bond and formation of a CX bond (X=C or heteroatom). This paper reviews the methods for the synthesis of phthalides and ,-butenolides by CH bond functionalization from non-halogenated starting materials. Over 30 methods are reported, mostly developed during the past ten years.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Renzetti, A; Fukumoto, K or concate me.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Rapid Characterization of Chemical Components in Edible Mushroom Sparassis crispa by UPLC-Orbitrap MS Analysis and Potential Inhibitory Effects on Allergic Rhinitis WOS:000482998900037 published article about MASS-SPECTROMETRY; FATTY-ACIDS; A-D; LIQUID-CHROMATOGRAPHY; KINASE INHIBITOR; FRUITING BODY; IDENTIFICATION; ANTIOXIDANT; HANABIRATAKE; METABOLITES in [Wang, Zhixin; Zhong, Xiangjian; Li, Jinjie; Wang, Xin; Ji, Linlin; Shang, Xiaoya] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, 191 Beitucheng West Rd, Beijing 100191, Peoples R China; [Liu, Jingyu] Shanxi Agr Univ, Coll Food Sci & Engn, 1 Mingxian South Rd, Jinzhong 030801, Taigu County, Peoples R China in 2019, Cited 108. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Formula: C8H6O2

Sparassis crispa is a kind of edible fungus widely grows in the north temperate zone, which shows various medicinal properties. Due to the complexity of chemical constitutes of this species, few investigations have acquired a comprehensive configuration for the chemical profile of it. In this study, a strategy based on ultra-high performance liquid chromatography (UPLC) combined with Orbitrap mass spectrometer (MS) was established for rapidly characterizing various chemical components in S. crispa. Through the summarized MS/MS fragmentation patterns of reference compounds and systematic identification strategy, a total of 110 components attributed to six categories were identified for the first time. Moreover, allergic rhinitis (AR) is a worldwide inflammatory disease seriously affecting human health, and the development of drugs to treat AR has been a topic of interest. It has been reported that the extracts of S. crispa showed obvious inhibitory effects on degranulation of mast cell- and allergen-induced IgE and proinflammatory mediators, but the active components and specific mechanism were still not clear. Src family kinases (SFKs) participate in the initial stage of allergy occurrence, which are considered the targets of AR treatment. Herein, on the basis of that self-built chemical database, virtual screening was applied to predict the potential SFKs inhibitors in S. crispa, using known crystal structures of Hck, Lyn, Fyn, and Syk as receptors, followed by the anti-inflammatory activity evaluation for screened hits by intracellular calcium mobilization assay. As results, sparoside A was directly confirmed to have strong anti-inflammatory activity with an IC50 value of 5.06 +/- 0.60 mu M. This study provides a useful elucidation for the chemical composition of S. crispa, and demonstrated its potential inhibitory effects on AR, which could promote the research and development of effective agents from natural resources.

Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, ZX; Liu, JY; Zhong, XJ; Li, JJ; Wang, X; Ji, LL; Shang, XY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Liang, XY; Yu, P; Fu, C; Shen, YC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Liang, Xiayu; Yu, Peng; Fu, Chen; Shen, Yongcun] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 122 Luoshi Rd, Wuhan 430070, Peoples R China in 2021, Cited 31. Safety of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactone with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active molecules tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method. (C) 2021 Elsevier Ltd. All rights reserved.

Safety of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Liang, XY; Yu, P; Fu, C; Shen, YC or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem