I found the field of Chemistry very interesting. Saw the article A chloroacetate based ratiometric fluorescent probe for cysteine detection in biosystems published in 2019. COA of Formula: C8H6O2, Reprint Addresses Dong, SL (corresponding author), Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China.; Dong, SL (corresponding author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tianshui South Rd, Lanzhou 730000, Gansu, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one
The specific detection of cysteine (Cys) over homocysteine (Hcy), glutathione (GSH) and other amino acids is of great significance for studying its biological functions as well as for the diagnosis of related diseases. Chloroacetyl group was often used as a reaction site for cysteine fluorescent probes for its sensitivity and selectivity. However, high background fluorescence and low stability are common problems encountered by such probes. Here, four chloroacetyl group based fluorescent probes (C1, C2, C3, and H4) was synthesized for a comparative study. We found that the inefficient quenching ability of chloroacetyl group turned into an advantage when connected with a ratiometric fluorophore. With the modification of chloroacetyl group, probe H4 displayed excellent ratiometric property and great selectivity for Cys, the stability was also improved. Additionally, the probe was successfully applied for quantitative detection of Cys in fetal bovine serum and real-time imaging in living HeLa cells with low toxicity. (C) 2019 Elsevier Ltd. All rights reserved.
COA of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Liu, ZK; Wang, QQ; Wang, H; Su, WT; Dong, SL or concate me.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem