In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1609071-04-6, name is 5,6-Bis((4-methoxybenzyl)oxy)isobenzofuran-1,3-dione, introducing its new discovery. name: 5,6-Bis((4-methoxybenzyl)oxy)isobenzofuran-1,3-dione
Conformationally constrained ortho- Anilino diaryl ureas: Discovery of 1-(2-(1?-Neopentylspiro[indoline-3,4?-piperidine]-1-yl)phenyl) -3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist
Preclinical antithrombotic efficacy and bleeding models have demonstrated that P2Y1 antagonists are efficacious as antiplatelet agents and may offer a safety advantage over P2Y12 antagonists in terms of reduced bleeding liabilities. In this article, we describe the structural modification of the tert-butyl phenoxy portion of lead compound 1 and the subsequent discovery of a novel series of conformationally constrained ortho-anilino diaryl ureas. In particular, spiropiperidine indoline-substituted diaryl ureas are described as potent, orally bioavailable small-molecule P2Y1 antagonists with improved activity in functional assays and improved oral bioavailability in rats. Homology modeling and rat PK/PD studies on benchmark compound 3l will also be presented. Compound 3l was our first P2Y1 antagonist to demonstrate a robust oral antithrombotic effect with mild bleeding liability in the rat thrombosis and hemostasis models.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1609071-04-6, and how the biochemistry of the body works.name: 5,6-Bis((4-methoxybenzyl)oxy)isobenzofuran-1,3-dione
Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H4242O – PubChem