Extracurricular laboratory: Synthetic route of Isobenzofuran-1(3H)-one

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Li, X; Shi, MQ; Chen, C; Du, JR or concate me.. HPLC of Formula: C8H6O2

HPLC of Formula: C8H6O2. Li, X; Shi, MQ; Chen, C; Du, JR in [Li, Xin; Shi, Meng-Qi; Du, Jun-Rong] Sichuan Univ, Educ Minist, Sichuan Engn Lab Plant Sourced Drug, Dept Pharmacol,Key Lab Drug Targeting & Drug Deli, Chengdu 610041, Peoples R China; [Li, Xin; Shi, Meng-Qi; Du, Jun-Rong] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Chengdu 610041, Peoples R China published Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3 in 2020, Cited 43. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The activation of NLRP3 inflammasome is closely related to ischemic brain injury and inhibition of NLRP3 inflammasome activation may be a new therapeutic strategy for ischemic stroke. Our previous studies showed that ligustilide (LIG) had a dose-dependent neuroprotective effect on various models of cerebral ischemia and dementia in vivo and in vitro. CD21, a kind of phthalide derivative, was modified from LIG. In this study, we established a global cerebral ischemia-reperfusion model in mice by bilateral common carotid artery ligation (2VO), and explored the neuroprotective effect of CD21 and its anti-inflammatory mechanism on cerebral ischemia mice. CD21 significantly improved weight loss, neurobehavioral deficits and neurons loss in hippocampal CA1 and caudate putamen (CPu) subregions, which were induced by 2VO in mice. CD21 significantly inhibited the overactivation of astrocyte and microglia, and decreased the mRNA level of IL-6, TNF-alpha and IL-1 beta. Moreover, CD21 significantly inhibited the activation of TLR4/NF-kappa B signaling pathway mediated by HMGB1 and NLRP3/ASC/Caspase-1 signaling pathway mediated by Cathepsin B, thus inhibiting the activation of NLRP3 inflammasome. Our results demonstrated that CD21 may exert a neuroprotection by inhibiting NLRP3 inflammasome activation after cerebral ischemia. These findings provide a new strategy for the treatment of ischemic stroke.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Li, X; Shi, MQ; Chen, C; Du, JR or concate me.. HPLC of Formula: C8H6O2

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A new application aboutIsobenzofuran-1(3H)-one

Recommanded Product: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lv, F; Xiao, J; Xiang, JC; Guo, FZ; Tang, ZL; Han, LB or concate me.

An article Conversion of Aryl Aldehydes to Benzyl Iodides and Diarylmethanes by H3PO3/I-2 WOS:000618540600061 published article about FRIEDEL-CRAFTS ALKYLATION; CYCLIZATION; HALIDES; ARENES; ACID; NUCLEOPHILES; ALCOHOLS; BROMIDES in [Lv, Fang; Xiao, Jing; Xiang, Junchun; Guo, Fengzhe; Tang, Zi-Long] Hunan Univ Sci & Technol, Minist Educ, Key Lab Theoret Organ Chem & Funct Mol, Sch Chem & Chem Engn, Xiangtan 411201, Peoples R China; [Han, Li-Biao] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058565, Japan in 2021, Cited 61. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: 87-41-2

For the first time, H3PO3 was used as both the reducing reagent and the promotor in the reductive benzylation reactions with aryl aldehydes. By using a H3PO3/I-2 combination, various aromatic aldehydes underwent iodination reactions and Friedel-Crafts type reactions with arenes via benzyl iodide intermediates, readily producing benzyl iodides and diarylmethanes in good yields. Intramolecular cyclization reactions also took place, giving the corresponding cyclic compounds. This new strategy features easy-handling, low-cost, and metal-free conditions.

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An update on the compound challenge: 87-41-2

Safety of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF or concate me.

Safety of Isobenzofuran-1(3H)-one. Recently I am researching about NF-KAPPA-B; TNF-ALPHA PRODUCTION; HEME OXYGENASE-1; INNATE IMMUNITY; INFLAMMATION; PATHWAY; NRF2; MACROPHAGES; ACTIVATION; INDUCTION, Saw an article supported by the National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [21977001]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalide is a promising chemical scaffold and has been proved to show potent anti-inflammatory efficacy. In this study, three series, total of 31 novel phthalide derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. The anti-inflammatory activity of all the compounds were screened on LPS induced NO production to evaluating their inhibitory effects. Structure-activity relationship has been concluded, and finally 3-((4-((4-ufluorobenzyl)oxy)phenyl)(-hydroxy)methyl)-5,7-dimethoxyisobenzofuran-1 (3H)-one (compound 9o) was found to be the active one with low toxicity, which showed 95.23% inhibitory rate at 10 mu M with IC50 value of 0.76 mu M against LPS-induced NO over expression. Preliminary mechanism studies indicated that compound 9o activated Nrf2/HO-1 signaling pathway via accumulation ROS and blocks the NF-kappa B/MAPK signaling pathway. The in vivo anti-inflammatory activity shown that compound 90 had obvious therapeutic effect against the adjuvant-induced rat arthritis model. (C) 2020 Elsevier Masson SAS. All rights reserved.

Safety of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

What kind of challenge would you like to see in a future of compound:C8H6O2

SDS of cas: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Sakurai, M; Kawakami, R; Kihara, N or concate me.

SDS of cas: 87-41-2. I found the field of Chemistry very interesting. Saw the article TBSOTf-promoted versatile N-formylation using DMF at room temperature published in 2019, Reprint Addresses Kihara, N (corresponding author), Kanagawa Univ, Fac Sci, Dept Chem, 2946 Tsuchiya, Hiratsuka, Kanagawa 2591293, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Hydrazides and amines were N-formylated by DMF in the presence of tert-butyldimethylsilyl triflate (TBSOTf) at room temperature, in good to excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.

SDS of cas: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Sakurai, M; Kawakami, R; Kihara, N or concate me.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

What I Wish Everyone Knew About 87-41-2

Quality Control of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Rangel-Montoya, EA; Paolinelli, M; Rolshausen, P; Hernandez-Martinez, R or concate me.

Quality Control of Isobenzofuran-1(3H)-one. In 2020 PHYTOPATHOL MEDITERR published article about LATENT PATHOGENS; FUNGAL MELANINS; BIOSYNTHESIS; BOTRYOSPHAERIACEAE; TRICYCLAZOLE; IDENTIFICATION; PENETRATION; GROWTH; MELANIZATION; APPRESSORIA in [Airam Rangel-Montoya, Edelweiss; Hernandez-Martinez, Rufina] Ctr Invest Cient & Educ Super Ensenada CICESE, Dept Microbiol, Ensenada 22860, Baja California, Mexico; [Paolinelli, Marcos] Inst Nacl Tecnol Agr INTA, Estn Expt Agr Mendoza, San Martin 3853, RA-5534 Mendoza, Argentina; [Paolinelli, Marcos] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina; [Rolshausen, Philippe] Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA in 2020, Cited 69. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Lasiodiplodia (Botryosphaeriaceae) includes fungi that are considered among the most aggressive to grapevine, capable of causing cankers and necrotic lesions which eventually lead to death of host plants. A common characteristic of this genus is the presence of melanin in conidia and mycelium. Melanin is produced by the oxidation of phenolic and/or indolic compounds. For some fungi, this pigment is an essential factor for pathogenicity. This study characterized the types and the roles of melanin produced by Lasiodiplodia gilanensis. Using specific melanin inhibitors, L. gilanensis was shown to synthesize DOPA-melanin, DHN-melanin, and pyomelanin. DOPA-melanin was shown to be involved in production of aerial mycelium and protection against enzymatic lysis and oxidative stress; DHN-melanin to be involved in ramification of mycelium when exposed to nutrient deficiency; and pyomelanin to be related with hyphae development. The fungus used tyrosine as a precursor of DOPA-melanin and as carbon and nitrogen sources, and produced melanin inside the piths of infected plants. Genes involved in melanin synthesis were conserved among the Botryosphaeriaceae, highlighting the importance of melanin in this family.

Quality Control of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Rangel-Montoya, EA; Paolinelli, M; Rolshausen, P; Hernandez-Martinez, R or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Let`s talk about compound :Isobenzofuran-1(3H)-one

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tian, XZ; Cheng, XQ; Yang, XZ; Ren, YL; Yao, KS; Wang, HY; Wang, JJ or concate me.. Recommanded Product: 87-41-2

Authors Tian, XZ; Cheng, XQ; Yang, XZ; Ren, YL; Yao, KS; Wang, HY; Wang, JJ in ROYAL SOC CHEMISTRY published article about METAL-FREE; SELECTIVE OXIDATION; MOLECULAR-OXYGEN; GRAPHENE OXIDE; IONIC LIQUID; FUNCTIONALIZATION; ACTIVATION; KETONES; AIR; DEHYDROGENATION in [Tian, Xinzhe] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China; [Wang, Huiyong; Wang, Jianji] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China; [Tian, Xinzhe; Cheng, Xinqiang; Ren, Yun-Lai; Yao, Kaisheng] Henan Univ Sci & Technol, Sch Chem Engn & Pharmaceut, Luoyang 471003, Henan, Peoples R China; [Yang, Xinzheng] Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China in 2019, Cited 84. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Catalyst-free, additive-free and light-free aerobic conversion of benzylic C-H to C?O bonds is reported. A series of C-H bonds in diphenylmethanes and benzyl ethers underwent this transformation to give the targeted products in low to high yields. The reaction mechanism was also investigated using radical trapping, DFT calculations and O-18-labelled experiments, and the results suggested that the present reaction relied on an activation of oxygen by the bond of the benzene ring.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tian, XZ; Cheng, XQ; Yang, XZ; Ren, YL; Yao, KS; Wang, HY; Wang, JJ or concate me.. Recommanded Product: 87-41-2

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Benzofuran – Wikipedia,
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The important role of C8H6O2

Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Qian, SQ; Li, ZQ; Li, MY; Wisniewski, SR; Qiao, JX; Richter, JM; Ewing, WR; Eastgate, MD; Chen, JS; Yu, JQ or concate me.

In 2020 ORG LETT published article about C-H FUNCTIONALIZATION; DERIVATIVES; ARYLATION; OXIDATION; ACTIVATION; BONDS in [Qian, Shaoqun; Li, Zi-Qi; Li, Minyan; Yu, Jin-Quan] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA; [Wisniewski, Steven R.; Eastgate, Martin D.] Bristol Myers Squibb, Chem & Synthet Dev, New Brunswick, NJ 08903 USA; [Chen, Jason S.] Scripps Res Inst, Automated Synth Facil, La Jolla, CA 92037 USA; [Qiao, Jennifer Xiaoxin; Ewing, William R.] Bristol Myers Squibb, Discovery Chem, Princeton, NJ 08543 USA; [Richter, Jeremy M.] Bristol Myers Squibb, Res & Dev, Hopewell, NJ 08534 USA in 2020, Cited 41. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biologically important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing.

Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Qian, SQ; Li, ZQ; Li, MY; Wisniewski, SR; Qiao, JX; Richter, JM; Ewing, WR; Eastgate, MD; Chen, JS; Yu, JQ or concate me.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Awesome Chemistry Experiments For C8H6O2

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Suwannarach, N; Kumla, J; Watanabe, B; Matsui, K; Lumyong, S or concate me.. Name: Isobenzofuran-1(3H)-one

Suwannarach, N; Kumla, J; Watanabe, B; Matsui, K; Lumyong, S in [Suwannarach, Nakarin; Kumla, Jaturong; Lumyong, Saisamorn] Chiang Mai Univ, Dept Biol, Fac Sci, Chiang Mai, Thailand; [Suwannarach, Nakarin; Kumla, Jaturong; Lumyong, Saisamorn] Chiang Mai Univ, Ctr Excellence Microbial Divers & Sustainable Uti, Chiang Mai, Thailand; [Watanabe, Bunta] Kyoto Univ, Inst Chem Res, Kyoto, Japan; [Matsui, Kenji] Yamaguchi Univ, Grad Sch Sci & Technol Innovat Agr, Yamaguchi, Japan; [Lumyong, Saisamorn] Royal Soc Thailand, Acad Sci, Bangkok, Thailand published Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319 in 2019, Cited 61. Name: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Melanin is a natural pigment that is produced by filamentous fungi. In this study, the endophytic species, Spissiomyces endophytica (strain SDBR-CMU319), produced a brownblack pigment in the mycelia. Consequently, the pigment was extracted from the dried fungal biomass. This was followed by pigment purification, characterization and identification. Physical and chemical characteristics of the pigment showed acid precipitation, alkali solubilization, decolorization with oxidizing agents, and insolubility in most organic solvents and water. The pigment was confirmed as melanin based on ultraviolet-visible spectroscopy, Fourier-transform infrared, and electron paramagnetic resonance spectra analyses. The analyses of the elemental composition indicated that the pigment possessed a low percentage of nitrogen, and therefore, was not 3,4-dihydroxyphenylalanine melanin. Inhibition studies involving specific inhibitors, both tricyclazole and phthalide, and suggest that fungal melanin could be synthesized through the 1,8-dihydroxynaphthalene pathway. The optimum conditions for fungal pigment production from this species were investigated. The highest fungal pigment yield was observed in glucose yeast extract peptone medium at an initial pH value of 6.0 and at 25 degrees C over three weeks of cultivation. This is the first report on the production and characterization of melanin obtained from the genus Spissiomyces.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Suwannarach, N; Kumla, J; Watanabe, B; Matsui, K; Lumyong, S or concate me.. Name: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

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Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Hassan, AY; Mohamed, MA; Abdel-Aziem, A; Hussain, AO or concate me.

In 2020 POLYCYCL AROMAT COMP published article about NATIONAL-CANCER-INSTITUTE; DRUG DISCOVERY; CELL-LINES in [Hassan, A. Y.; Abdel-Aziem, A.; Hussain, A. O.] Al Azhar Univ, Chem Dept, Fac Sci, Girls Branch, POB 11754,Yousef Abbas Str, Cairo, Egypt; [Mohamed, M. A.] Al Azhar Univ, Girls Branch, Fac Sci, Biochem Div,Chem Dept, Cairo, Egypt in 2020, Cited 25. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: Isobenzofuran-1(3H)-one

5-Amino-1-phenyl-1H-pyrazole-4-carbohydraizde(1) was used as a key to synthesize new imidazopyrazol-5(1H)-one 5, pyrazolopyrimidines 7 and 9. Furthermore, imidazopyrazoles 13, 15, pyrazolopyridine 16 and pyrazolopyrazolopyridopyrimidine 17 were prepared from pyrazoles 10 and 11. The structure of the new compounds was confirmed by spectral data as well as elemental analysis. Some compounds were selected by the national cancer institute NCI (USA) for anticancer activity against different human cancer cell lines. The results indicated that compound 12 exhibited strong anticancer activity toward Renal Cancer UO-31(GI, 42.81%), while compound 3 was strong active against Breast Cancer MCF7 (GI, 49.88%) and moderate against T-47D (GI, 38.15%) cell lines. However, compound 17 showed strong activity against Leukemia CCRF-CEM (GI, 41.37%) and SR (GI, 44.95%), whereas, compound 9 showed weak activity toward all tested cancer cell lines.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemical Properties and Facts of 87-41-2

Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Fang, X; Ma, Q; Zhang, KX; Yao, SY; Feng, Y; Jin, YS; Liang, S or concate me.

An article Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities WOS:000497933800001 published article about ENDOTHELIAL-CELLS; OXIDATIVE STRESS; SENKYUNOLIDE I; Z-LIGUSTILIDE; CHUANXIONG; INJURY; STROKE in [Fang, Xin; Ma, Qiang; Feng, Yi; Liang, Shuang] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China; [Zhang, Kai-Xia; Yao, Song-Yun; Jin, Yong-Sheng] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China in 2020, Cited 25. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

As part of our continuing efforts to discover structurally interesting bioactive phthalide derivatives, 23 of them with a structure incorporating thiophen or halogens were designed and synthesized, 17 of which are previously unreported. In vitro antiplatelet aggregation activity screening showed that 14b could significantly inhibit platelet aggregation induced by arachidonic acid, compared with edaravone (p < 0.01). Meanwhile, oxidative damage models using SH-SY5Y and PC12 cells induced by H2O2 were built to evaluate the antioxidant activity of the phthalide derivatives. In SH-SY5Y cells, compared with aspirin, 1a significantly increased the relative cell survival rate (p < 0.05). Compared with edaravone, 1a (p < 0.01) and 15b (p < 0.05) significantly increased the relative cell survival rate. In PC12 cells, 1a (p < 0.01), 15b (p < 0.01), and 12a (p < 0.05) remarkably increased the cell survival rate compared with edaravone. The present study identified lead structures to develop potential anti-ischemic stroke agents. Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Fang, X; Ma, Q; Zhang, KX; Yao, SY; Feng, Y; Jin, YS; Liang, S or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem