Heterocyclic Building Block-benzofuran

4687-25-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4687-25-6, Name is Benzofuran-3-carbaldehyde, molecular formula is C9H6O2. In a Article, authors is Paul, Noel M.£¬once mentioned of 4687-25-6

Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol

Discovering dopamine D2-like receptor subtype-selective ligands has been a focus of significant investigation. The D2R-selective antagonist 3-[4-(4-chlorophenyl)-4-hydroxypiperidinyl]methylindole (1, L741,626; K i(D2R/D3R) = 11.2:163 nM) has previously provided a lead template for chemical modification. Herein, analogues have been synthesized where the piperidine was replaced by a tropane ring that reversed the selectivity seen in the parent compound, in human hD2LR- or hD3R-transfected HEK 293 cells (31, Ki(D2R/D3R) = 33.4: 15.5 nM). Further exploration of both N-substituted and aryl ring-substituted analogues resulted in the discovery of several high affinity D2R/D3R ligands with 3-benzofurylmethyl-substituents (e.g., 45, Ki(D2R/D3R) = 1.7:0.34 nM) that induced high affinity not achieved in similarly N-substituted piperidine analogues and significantly (470-fold) improved D3R binding affinity compared to the parent ligand 1. X-ray crystallographic data revealed a distinctive spatial arrangement of pharmacophoric elements in the piperidinol vs tropine analogues, providing clues for the diversity in SAR at the D2 and D3 receptor subtypes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.4687-25-6. In my other articles, you can also check out more blogs about 4687-25-6

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1201O – PubChem

4265-25-2, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4265-25-2, name is 2-Methylbenzofuran. In an article£¬Which mentioned a new discovery about 4265-25-2

Gold-Catalyzed Controllable C2-Functionalization of Benzofurans with Aryl Diazoesters

A ligand-controlled gold-catalyzed chemoselective C2-functionalization of benzofuran substrates with aryl diazoesters has been developed. The use of IPrAu(PhCN)BArF provides unprecedented dearomatization products bearing a newly formed carbon-carbon double bond at the C2 position of benzofurans. In contrast, the C2-alkylation products have been isolated as the major products for phosphite gold catalysis.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4265-25-2 is helpful to your research. 4265-25-2

Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H329O – PubChem

In an article, published in an article,authors is Bonse, Gerhard, once mentioned the application of 66826-78-6, Name is 5-Bromo-2,3-dihydrobenzofuran,molecular formula is C8H7BrO, is a conventional compound. this article was the specific content is as follows. 66826-78-6

Acylation of Amines with Dichloromaleoyl Chloride

The reaction of dichloromaleoyl chloride (2) with ammonia in ether yields the ammonium salt of (Z)-2,3-dichloro-3-cyanoacrylic acid (6) and with aqueous ammonia the ammonium salt of (Z)-2-amino-3-chloro-3-cyanoacrylic acid (1).With primary aliphatic and aromatic amines dichloromaleamides 8 are obtained, the two chlorine atoms of which can be replaced with other amines to form after cis/trans isomerization diaminofumaramides 11.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3356O – PubChem

4265-25-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4265-25-2, Name is 2-Methylbenzofuran, molecular formula is C9H8O. In a article£¬once mentioned of 4265-25-2

Direct conversion of glycerol into bio-oil via hydrotreatment using supported metal catalysts

Hydrotreatment of glycerol (a byproduct of bio-diesel production) was conducted in the presence of a number of different supported metal catalysts at a temperature of 300 C under 5 MPa initial pressure of H2. The bio-oil products were comprehensively characterized to determine their physical/chemical properties. Experiments with supported catalyst metals revealed a positive correlation between support acidity and bio-oil yield. It was determined that MoCoP is the most effective combination of catalyst metals, and the bio-oil yield from hydro-treatment of glycerol with the MoCoP catalysts is strongly dependent on the support materials, following the trend of MgO < AC < Al2O3 < zeolite. With the MoCoP/zeolite catalyst, a maximum yield of ?40 wt.% bio-oil, and >90% glycerol conversion was achieved for 60 min reaction. The volatile components of the bio-oil were found to consist mostly of substituted phenols and ketones in the C6-C9 range. The bio-oils obtained had a maximum HHV of 33 MJ/kg and the majority (?95%) of the compounds present was found to have boiling points lower than 165 C, making these bio-oils potential oxygenated fuel additives.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 4265-25-2, In my other articles, you can also check out more blogs about 4265-25-2

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Benzofuran – Wikipedia,
Benzofuran | C8H298O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 90843-31-5, In a patent£¬Which mentioned a new discovery about 90843-31-5

Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents

This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein A is C 1-6 alkylene or ?NR1?; Z is C(=L)R2, or SO2R3; U is CH or N; W and Y are independently selected from ?CH2?, O, S and ?N?R1; m is 1, 2 or 3; q and r are independently 0, 1 or 2; X is independently selected from halogen, C1-4 alkyl, halo-substituted C1-4 alkyl, hydroxy, C1-4 alkoxy, halo-substituted C1-4 alkoxy or the like; n is 1 or 2; L is oxygen or sulfur; R1 is hydrogen or C1-4 alkyl; R2 is hydroxy, C1-6alkyl, halo-substituted C1-6 alkyl, C1-6 alkoxy, halo-substituted C1-6 alkoxy, C3-7 cycloalkoxy, C1-4 alkyl(C3-7 cycloalkoxy), ?NR4R5 or the like; R3 is C1-6 alkyl or halo-substituted C1-6 alkyl; and R4 and R5 are independently selected from hydrogen, C1-6 alkyl and halo-substituted C1-6alkyl.This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

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Benzofuran – Wikipedia,
Benzofuran | C8H2058O – PubChem

4687-25-6, Benzofuran-3-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of benzofuran-3-carbaldehyde (5 g, 33.8 mmol) in methanol (50 mL) was cooled with ice and sodium borohydride (1.9 g, 50.7 mmol) was added portionwise. The reaction mixture was stirred at rt for 1 h. The mixture was concentrated and the residue was partitioned between saturated ammonium chloride and DCM. The organic layer was separated, dried over sodium sulfate and concentrated. The crude benzofuran-3-ylmethanol (4.6 g, 92%) was taken as such for next step without further purification.

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Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (302 pag.)WO2019/99582; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

209256-42-8, 2,3-Dihydrobenzofuran-4-carbaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1050 mL (1.05 mol) of a 1.0 M solution of vinyl magnesium bromide in tetrahydrofuran was added to the reaction flask, the stirring was started, the reaction solution was cooled to -10 to -5 C, and 2,3-dihydrobenzofuran-4 was added dropwise. -A solution of formaldehyde (148.2 g, 1.00 mol) in tetrahydrofuran (500 mL), and the temperature of the reaction solution is controlled to not exceed -5 C. After the completion of the dropwise addition, the reaction was maintained at a temperature of -10 to -5 C for half an hour, and then slowly warmed to room temperature to continue the reaction. After 6 hours, 300 mL of a saturated ammonium chloride aqueous solution was added, and after stirring for 30 minutes, extraction was performed with ethyl acetate three times (800 mL ¡Á 3). The organic phase was washed once with a saturated sodium chloride solution (300 mL) and water (300 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated to dryness under reduced pressure to obtain 173.6 g of a yellow oil with a yield of 98.5%., 209256-42-8

The synthetic route of 209256-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Changzhou Yabang Pharmaceutical Co., Ltd.; Chen Zaixin; Ji Xiaolong; Xia Zhengjun; Zang Lujie; Xia Lingxian; Hao Jinxing; Wang Fan; (12 pag.)CN104926763; (2019); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

4265-16-1,4265-16-1, Benzo[b]furan-2-carboxaldehyde is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

10242-10-1, 5-Chlorobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-chlorobenzofuran-2-carboxylic acid (0.274 g, 1.4 mmol, 1.5 equiv) in DMF (10 mL) was added DIPEA (0.5 mL, 2.7 mmol, 3.0 equiv) followed by the addition of HATU (0.706 g, 1.8 mmol, 2.0 equiv) and the resultant reaction mixture was stirred for 30 min. Trans-tert-butyl (4-aminocyclohexyl)carbamate (0.200 g, 0.90 mmol, 1.0 equiv) was added and the reaction mixture was allowed to stir overnight at RT and the resulting precipitate was filtered off and washed with excess methanol to obtain trans-tert-butyl (4-(5-chlorobenzofuran-2-carboxamido)cyclohexyl)carbamate (350 mg, 64% Yield) as an off-white solid. LCMS: 393 [M+H]+., 10242-10-1

10242-10-1 5-Chlorobenzofuran-2-carboxylic acid 937838, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Praxis Biotech LLC; BERNALES, Sebastian; DELGADO OYARZO, Luz Marina; NUNEZ VASQUEZ, Gonzalo Esteban; URETA DIAZ, Gonzalo Andres; PUJALA, Brahmam; PANPATIL, Dayanand; BHATT, Bhawana; CHAKRAVARTY, Sarvajit; US2019/177310; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

35700-40-4, 2,3-Dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 2,3-dihydro-l-benzofuran-7-ylmethanol [00878] Added BH3 (1M in THF, 9 mL) to a solution of 2,3-dihydro-l-benzofuran-7- carboxylic acid (481 mg, 2.93 mmol) in THF (7 mL) drop wise at 0C, thereto, the mixture was stirred at room temperature overnight. Extracted with ethyl acetate twice, and washed the organic phase with brine and dried with anhydrous Na2S04, concentrated to give the title compound (340 mg, 77%). 1H NMR (400 MHz, CDC13): delta 2.09 (1H, s), 3.22 (2H, t, J= 8.8 Hz), 4.61 (2H, t, J= 8.8 Hz), 4.67 (2H, s), 6.83 (1H, t, J= 7.6 Hz), 7.08 (1H, d, J= 7.2 Hz), 7.14 (1H, d, J= 7.2 Hz)., 35700-40-4

The synthetic route of 35700-40-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; QUANTICEL PHARMACEUTICALS, INC; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan; WO2014/89364; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem