Heterocyclic Building Block-benzofuran

An examination of analysis of histamine in food for health risk management was written by Hanaishi, Ryuji;Yamamoto, Akemi. And the article was included in Aomori-ken Kankyo Hoken Senta Kenkyu Hokoku in 2019.Formula: C17H10O4 This article mentions the following:

A rapid anal. method of histamine in food for health risk management cases was explored. As a basic technique, the present authors adopted a method already reported by Kikuchi et al. (Hiroyuki Kikuchi et al., 2012), in which the eluted solution purified by solid-phase extraction using a C18 cartridge and a strongly acidic cation exchange resin cartridge was derivatized with fluorescamine. The method was modified using tetrabutylammonium hydroxide (TBAH) as a base in the eluted solution in the purification step to shorten the time required for anal. At the time of drawing a calibration line based on the results of standard solution measurement, percent differences were calculated and the ranges of the calibration line were determined, and spike recovery rates were calculated using sardine dried whole. Using the TBAH method, sufficient recovery rates were obtained, suggesting that the TBAH method was useful as an anal. method in health risk management. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

All in one theranostic nanoagent based on MoSe₂/Au@PEG hollow nanospheres for the enhanced synergetic antitumor was written by Li, Yang;Wang, Limin;Kang, Keke;Ma, Yajie;Yu, Kai;Lu, Tong;Qu, Fengyu;Lin, Huiming. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.HPLC of Formula: 76-54-0 This article mentions the following:

MoSe2/Au@PEG nanoheterostructure were synthesized to integrate multi-imaging and therapeutic strategies into one nanoplatform. These Au nanoparticles were deposited on the surface of MoSe2 hollow nanospheres (250 nm) to reveal the enhanced NIR harvest owing to localized surface plasma resonance of Au, which could be varied with the particle sizes and the distance of Au nanoparticles. Therefore, MoSe2/Au@PEG nanocomposites revealed the great photothermal conversion efficiency to 73.0 %. In addition, they also exhibited the promoted reactive oxygen species (ROS) generation about 4-times as the pure sample, owing to the plasmon-mediated electron-transfer between the two components. Besides, the peroxidase and catalase activity of MoSe2 could convert the intracellular H2O2 to ·OH and O2 for chemotherapy. In addition, the glucose oxidase activity of Au made the H2O2 supplement for promoted chemodynamic therapy (CDT) and the glucose consumption for starvation therapy. It noted that the MoSe2/Au@PEG heterostructure also increased the nanozyme activity (2 times), ascribing to the decreased resistant of the charge transfer. The photothermal/photodynamic/starvation therapy combined with CDT could bring the immunogenic cell death that was associated with anti-CTLA4 to further arouse immune response to eliminate the primary as well as metastatic tumors. In addition, the novel biodegradation of the nanocomposite made the elimination via urine and feces within 18 d. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0HPLC of Formula: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.HPLC of Formula: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gram scale synthesis of Fe/Fe_xO_y core-shell nanoparticles and their incorporation into matrix-free superparamagnetic nanocomposites was written by Watt, John;Bleier, Grant C.;Romero, Zachary W.;Hance, Bradley G.;Bierner, Jessica A.;Monson, Todd C.;Huber, Dale L.. And the article was included in Journal of Materials Research in 2018.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione This article mentions the following:

Significant reductions recently seen in the size of wide-bandgap power electronics have not been accompanied by a relative decrease in the size of the corresponding magnetic components. To achieve this, a new generation of materials with high magnetic saturation and permeability are needed. Here, we develop gram-scale syntheses of superparamagnetic Fe/Fe_xO_y core-shell nanoparticles and incorporate them as the magnetic component in a strongly magnetic nanocomposite. Nanocomposites are typically formed by the organization of nanoparticles within a polymeric matrix. However, this approach can lead to high organic fractions and phase separation; reducing the performance of the resulting material. Here, we form aminated nanoparticles that are then cross-linked using epoxy chem. The result is a magnetic nanoparticle component that is covalently linked and well separated By using this ‘matrix-free’ approach, we can substantially increase the magnetic nanoparticle fraction, while still maintaining good separation, leading to a superparamagnetic nanocomposite with strong magnetic properties. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Name: 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterization and biological activities of some new azetidin-2-ones and thiazolidin-4-ones bearing benzofuran moiety was written by Tiriapur, Vijay Kumar;Basawaraj, Raga. And the article was included in Indian Journal of Heterocyclic Chemistry in 2012.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

1-(5-Bromo-1-benzofuran-2-yl)ethanone hydrazone (I) was obtained by condensation of 5-bromo-2-acetylbenzofuran with NH₂NH₂. The compound I on treatment with substituted aldehydes in presence of ethanol gave azine compounds The reaction of these azine compounds with chloroacetyl chloride and few drops of Et₃N in presence of dry benzene afforded the corresponding 1-{[1-(5-bromo-1-benzofuran-2-yl)ethylidene]amino}-3-chloro-4-(substituted phenyl)azetidine-2-ones. The treatment of the azine compounds with mercaptoacetic acid in presence of DMF furnished 3-{[1-(5-bromo-1-benzofuran-2-yl)ethylidene]amino}-2-(substituted phenyl)-1,3-thiazolidine-4-ones, resp. All newly synthesized compounds were characterized on the basis of IR, ¹H NMR and mass spectral data and screened for their antitubercular, antibacterial, and antifungal activities. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemical Composition of Bee Pollen and Leishmanicidal Activity of Rhusflavone was written by Gomes, Ayala Nara Pereira;Camara, Celso Amorim;dos Santos Sousa, Alexsandro;de Assis Ribeiro dos Santos, Francisco;de Santana Filho, Paulo Cesar;Dorneles, Gilson Pires;Romao, Pedro Roosevelt Torres;Silva, Tania Maria Sarmento. And the article was included in Revista Brasileira de Farmacognosia in 2021.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Bee pollen monofloral from Attalea funifera Mart., Arecaceae, known as piacava, was analyzed with ultra-performance liquid chromatog. coupled with diode array detector and quadrupole time-of-flight mass spectrometry for the profiling and structural characterization of the replicated compounds The principal compound was isolated and tested against Leishmania amazonensis. Fifty-eight compounds were identified, including one sugar, ten flavonoids, two putrescine derivatives, sixteen hydroxycinnamic acid amide derivatives, two coumarate derivatives, and twenty-seven lipids. The isolated compound identified as the biflavonoid rhusflavone showed high leishmanicidal activity against both promastigote (IC₅₀ = 5 μM) and amastigote (76.7% mortality at 2 μM) forms of L. amazonensis, acting via a mechanism involving reactive oxygen species production, mitochondrial dysfunction, and membrane disruption in parasites. The compound showed low toxicity to mammalian cells and human erythrocytes, with selectivity index for erythrocytes >100 and for macrophages (CC50 macrophages/IC₅₀ amastigotes) > 10. These results indicate that rhusflavone is a promising candidate for the development of drugs against L. amazonensis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Benzofuran derivatives. XVI. Infrared spectra of coumarilic acid esters was written by Goldenberg, C.;Binon, F.. And the article was included in Bulletin des Societes Chimiques Belges in 1966.Electric Literature of C10H8O3 This article mentions the following:

The ir spectra of coumarilic acid esters in CS₂ showed 2 peaks in the carbonyl stretching region. Exptl. it was proved that this splitting was not due to a Fermi resonance or to the existence of dimers. The splitting was ascribed to the link XCCOOR(X = O or N) in a cyclic or acyclic structure, in which 2 rotational isomers were present in equilibrium In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Electric Literature of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Electric Literature of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile access to biaryls and 2-acetyl-5-arylbenzofurans via Suzuki coupling in water under thermal and microwave conditions was written by Darweesh, Ahmed F.;Shaaban, Mohamed R.;Farag, Ahmad M.;Metz, Peter;Dawood, Kamal M.. And the article was included in Synthesis in 2010.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone This article mentions the following:

Phosphine-free Suzuki-Miyaura C-C cross-coupling reactions of activated and deactivated aryl halides and 2-acetyl-5-bromobenzofuran with various aryl- or heteroarylboronic acids were investigated. A benzothiazole-based Pd(II) complex was used as a pre-catalyst for the reactions under both thermal and microwave conditions in air using water as a solvent. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone).

1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Application In Synthesis of 1-(5-Bromobenzofuran-2-yl)ethanone

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Covalent cross-links in polyampholytic chitosan fibers enhances bone regeneration in a rabbit model was written by Ghosh, Paulomi;Rameshbabu, Arun Prabhu;Das, Dipankar;Francis, Nimmy K.;Pawar, Harpreet Singh;Subramanian, Bhuvaneshwaran;Pal, Sagar;Dhara, Santanu. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2015.Formula: C17H10O4 This article mentions the following:

Chitosan fibers were prepared in citric acid bath, pH 7.4 and NaOH solution at pH 13, to form ionotropically cross-linked and uncross-linked fibers, resp. The fibers formed in citric acid bath were further cross-linked via carbodiimide chem.; wherein the pendant carboxyl moieties of citric acid were used for new amide bond formation. Moreover, upon covalent crosslinking in the ionically gelled citrate-chitosan fibers, incomplete conversion of the ion pairs to amide linkages took place resulting in the formation of a dual network structure. The dual cross-linked fibers displayed improved mech. property, higher stability against enzymic degradation, hydrophobicity and superior bio-mineralization compared to the uncross-linked and native citrate cross-linked fibers. Addnl., upon cyclic loading, the ion pairs in the dual cross-linked fibers dissociated by dissipating energy and reformed during the relaxation period. The twin property of elasticity and energy dissipation mechanism makes the dual cross-linked fiber unique under dynamic mech. conditions. The differences in the physico-chem. characteristics were reflected in protein adsorption, which in turn influenced the cellular activities on the fibers. Compared to the uncross-linked and ionotropically cross-linked fibers, the dual cross-linked fibers demonstrated higher proliferation and osteogenic differentiation of the MSCs in vitro as well as better osseous tissue regeneration in a rabbit model. In the experiment, the researchers used many compounds, for example, 4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9Formula: C17H10O4).

4-Phenyl-3H,3’H-spiro[furan-2,1′-isobenzofuran]-3,3′-dione (cas: 38183-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Formula: C17H10O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Pulmonary oxidative stress in wild bats exposed to coal dust: A model to evaluate the impact of coal mining on health was written by Pedroso-Fidelis, Giulia dos Santos;Farias, Hemelin Resende;Mastella, Gustavo Antunes;Boufleur-Niekraszewicz, Liana Appel;Dias, Johnny Ferraz;Alves, Marcio Correa;Silveira, Paulo Cesar Lock;Nesi, Renata Tiscoski;Carvalho, Fernando;Zocche, Jairo Jose;Pinho, Ricardo Aurino. And the article was included in Ecotoxicology and Environmental Safety in 2020.Electric Literature of C20H10Cl2O5 This article mentions the following:

This study aimed to verify possible alterations involving histol. and oxidative stress parameters in the lungs of wild bats in the Carboniferous Basin of Santa Catarina (CBSC) state, Southern Brazil, as a means to evaluate the impact of coal dust on the health of wildlife. Specimens of frugivorous bat species Artibeus lituratus and Sturnira lilium were collected from an area free of coal dust contamination and from coal mining areas. Chem. composition, histol. parameters, synthesis of oxidants and antioxidant enzymes, and oxidative damage in the lungs of bats were analyzed. Levels of Na, Cl, Cu, and Br were higher in both species collected in the CBSC than in the controls. Levels of K and Rb were higher in A. lituratus, and levels of Si, Ca, and Fe were higher in S. lilium collected in the carboniferous basin. Both bat species inhabiting the CBSC areas exhibited an increase in the degree of pulmonary emphysema compared to their counterparts collected from control areas. Sturnira lilium showed increased reactive oxygen species (ROS) and 2′,7′-dichlorofluorescein (DCF) levels, while A. lituratus showed a significant decrease in nitrite levels in the CBSC samples. Superoxide dismutase (SOD) activity did not change significantly; however, the activity of catalase (CAT) and levels of glutathione (GSH) decreased in the A. lituratus group from CBSC compared to those in the controls. There were no differences in NAD(P)H quinone dehydrogenase 1 protein (NQO1) abundance or nitrotyrosine expression among the different groups of bats. Total thiol levels showed a significant reduction in A. lituratus from CBSC, while the amount of malondialdehyde (MDA) was higher in both A. lituratus and S. lilium groups from coal mining areas. Our results suggested that bats, especially A. lituratus, living in the CBSC could be used as sentinel species for harmful effects of coal dust on the lungs. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Electric Literature of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Electric Literature of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice. was written by Rodrigues, Matheus Scarpatto;Pieri, Bruno Luiz da Silva;Silveira, Gustavo de Bem;Zaccaron, Rubya Pereira;Venturini, Ligia Milanez;Comin, Vitor Hugo;Luiz, Karine Damian;Silveira, Paulo Cesar Lock. And the article was included in Einstein (Sao Paulo, Brazil) in 2020.Related Products of 76-54-0 This article mentions the following:

OBJECTIVE: To evaluate the effects of oxidative stress on insulin signaling in cardiac tissue of obese mice. METHODS: Thirty Swiss mice were equally divided (n=10) into three groups: Control Group, Obese Group, and Obese Group Treated with N-acetylcysteine. After obesity and insulin resistance were established, the obese mice were treated with N-acetylcysteine at a dose of 50mg/kg daily for 15 days via oral gavage. RESULTS: Higher blood glucose levels and nitrite and carbonyl contents, and lower protein levels of glutathione peroxidase and phosphorylated protein kinase B were observed in the obese group when compared with their respective control. On the other hand, treatment with N-acetylcysteine was effective in reducing blood glucose levels and nitrite and carbonyl contents, and significantly increased protein levels of glutathione peroxidase and phosphorylated protein kinase B compared to the Obese Group. CONCLUSION: Obesity and/or a high-lipid diet may result in oxidative stress and insulin resistance in the heart tissue of obese mice, and the use of N-acetylcysteine as a methodological and therapeutic strategy suggested there is a relation between them. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem