Chemical Composition of Bee Pollen and Leishmanicidal Activity of Rhusflavone was written by Gomes, Ayala Nara Pereira;Camara, Celso Amorim;dos Santos Sousa, Alexsandro;de Assis Ribeiro dos Santos, Francisco;de Santana Filho, Paulo Cesar;Dorneles, Gilson Pires;Romao, Pedro Roosevelt Torres;Silva, Tania Maria Sarmento. And the article was included in Revista Brasileira de Farmacognosia in 2021.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:
Bee pollen monofloral from Attalea funifera Mart., Arecaceae, known as piacava, was analyzed with ultra-performance liquid chromatog. coupled with diode array detector and quadrupole time-of-flight mass spectrometry for the profiling and structural characterization of the replicated compounds The principal compound was isolated and tested against Leishmania amazonensis. Fifty-eight compounds were identified, including one sugar, ten flavonoids, two putrescine derivatives, sixteen hydroxycinnamic acid amide derivatives, two coumarate derivatives, and twenty-seven lipids. The isolated compound identified as the biflavonoid rhusflavone showed high leishmanicidal activity against both promastigote (IC50 = 5 μM) and amastigote (76.7% mortality at 2 μM) forms of L. amazonensis, acting via a mechanism involving reactive oxygen species production, mitochondrial dysfunction, and membrane disruption in parasites. The compound showed low toxicity to mammalian cells and human erythrocytes, with selectivity index for erythrocytes >100 and for macrophages (CC50 macrophages/IC50 amastigotes) > 10. These results indicate that rhusflavone is a promising candidate for the development of drugs against L. amazonensis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).
2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem