Heterocyclic Building Block-benzofuran

Synthesis of Chalcone Derivatives Containing Furan or/and Pyran Ring as Neuraminidase Inhibitors was written by Chen, Aiyu;Liang, Yongdong;Ye, Jiao;Hu, Aixi;Lian, Wenwen;Liu, Ailin;Du, Guanhua. And the article was included in Chemical Research in Chinese Universities in 2019.Name: 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol This article mentions the following:

Twenty-seven novel chalcone derivatives were designed and synthesized as neuraminidase(NA) inhibitors. A concise suitable synthetic strategy was employed in the target compounds’ synthesis with relatively high yields. The synthesized compounds were evaluated for their inhibitory activities against the NA of influenza A virus in vitro. The results show that compound 9b possesses the most potent NA inhibitory activity. Structure-activity relationship studies indicate that the chalcone system and hydrogen bond donor substituent are significant for the NA inhibitory activity. And the chalcone derivatives containing pyran ring have better NA inhibitory activity than those without the pyran ring. In addition, mol. docking studies reveal that compounds 9b and 9u are in the good binding mode with Zanamivir binding sites. This study indicates that compound 9b could be selected as a potent compound for further structural optimization and development of novel NA inhibitors. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Name: 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Name: 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An overview of the efficacy and safety of prucalopride for the treatment of chronic idiopathic constipation was written by Daniali, Marzieh;Nikfar, Shekoufeh;Abdollahi, Mohammad. And the article was included in Expert Opinion on Pharmacotherapy in 2019.Synthetic Route of C18H26ClN3O3 This article mentions the following:

: Chronic idiopathic constipation (CIC) is a kind of constipation in which the patient experiences constipation more than 3 mo without any identifiable cause. Prucalopride is one such treatment considered for relieving symptoms of CIC regarding due to its selectivity for the 5HT4 receptor.: This article is based on a PubMed and clinicaltrials.gov search for studies undertaken over the past 19 years (2000-2019) using the following keywords either alone or in combination: Prucalopride, chronic idiopathic constipation, chronic constipation, 5HT4 receptor, Resolor and Motegrity.: Prucalopride should be considered as one of the safe options for the treatment of CIC especially when previous treatments have failed. It can be helpful in the treatment of constipation caused by irritable bowel syndrome or spinal cord injury, opioid-induced constipation, post-operative ileus, and intestinal/colonic pseudo-obstruction. The major drawback of prucalopride is its high cost, which makes it less accessible to all patients. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8Synthetic Route of C18H26ClN3O3).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Synthetic Route of C18H26ClN3O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An unnatural base pair system for efficient PCR amplification and functionalization of DNA molecules was written by Kimoto, Michiko;Kawai, Rie;Mitsui, Tsuneo;Yokoyama, Shigeyuki;Hirao, Ichiro. And the article was included in Nucleic Acids Research in 2009.COA of Formula: C25H15NO9 This article mentions the following:

Toward the expansion of the genetic alphabet, we present an unnatural base pair system for efficient PCR amplification, enabling the site-specific incorporation of extra functional components into DNA. This system can be applied to conventional PCR protocols employing DNA templates containing unnatural bases, natural and unnatural base triphosphates, and a 3’→5′ exonuclease-proficient DNA polymerase. For highly faithful and efficient PCR amplification involving the unnatural base pairing, we identified the natural-base sequences surrounding the unnatural bases in DNA templates by an in vitro selection technique, using a DNA library containing the unnatural base. The system facilitates the site-specific incorporation of a variety of modified unnatural bases, linked with functional groups of interest, into amplified DNA. DNA fragments (0.15 amol) containing the unnatural base pair can be amplified 10⁷-fold by 30 cycles of PCR, with <1% total mutation rate of the unnatural base pair site. Using the system, we demonstrated efficient PCR amplification and functionalization of DNA fragments for the extremely sensitive detection of zeptomol-scale target DNA mols. from mixtures with excess amounts (pmol scale) of foreign DNA species. This unnatural base pair system will be applicable to a wide range of DNA/RNA-based technologies. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7COA of Formula: C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.COA of Formula: C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca²⁺ channel blockers was written by Yu, Sheu Meei;Ko, Feng Nien;Su, Ming Jai;Wu, Tian Shung;Wang, Meei Ling;Huang, Tur Fu;Teng, Che Ming. And the article was included in Naunyn-Schmiedeberg’s Archives of Pharmacology in 1992.Related Products of 28808-62-0 This article mentions the following:

The components of D. dasycarpus Turcz were tested for their vasorelaxing effect on the rat aorta, and fraxinellone (I) and dictamine (II) were shown to be effective vasorelaxants. In high K⁺ (60 mmol/L) medium, Ca²⁺ (0.03 to 3 mmol/L)-induced vasoconstriction was inhibited concentration-dependently by both agents. The IC₅₀ for I and II were calculated to be about 25 μmol/L and 15 μmol/L (for Ca²⁺ concentration of 1 mmol/L), resp. Cromakalim (0.2-10 μmol/L) relaxed aortic rings precontracted with 15 but not 60 mmol/L of K⁺. I and verapamil were more potent and effective in producing relaxation in 60 mmol/L than in 15 mmol/L K⁺-induced contraction. However, II was more potent in producing relaxation in 15 mmol/L K⁺-induced contraction. Nifedipine (1 μmol/L), II (100 μmol/L) and I (100 μmol/L) relaxed the aortic contraction caused by KCl or Bay K 8644. The tonic contraction elicited by noradrenaline (NA, 3 μmol/L) was also relaxed by II (500 μmol/L), but not by I (500 μmol/L) in the nifedipine (1 μmol/L)-treated aorta. This relaxing effect of II persisted in endothelium-denuded aorta. Glibenclamide (10 μmol/L) shifted the concentration-relaxation curve of cromakalim, but not that of II, to the right in rat aortic rings precontracted with NA. II (500 μmol/L) did not affect tonic contraction of NA which are reduced by H-7 (1 μmol/L) in Ca²⁺-depleted medium. In conclusion, I is a selective blocker of voltage-dependent Ca²⁺ channel, while II relaxes the rat aorta by suppressing the Ca²⁺ influx through both voltage-dependent and receptor-operated Ca²⁺ channels. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Related Products of 28808-62-0).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 28808-62-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Selective Enzymatic Degradation of Self-Assembled Particles from Amphiphilic Block Copolymers Obtained by the Combination of N-Carboxyanhydride and Nitroxide-Mediated Polymerization was written by Habraken, Gijs J. M.;Peeters, Marloes;Thornton, Paul D.;Koning, Cor E.;Heise, Andreas. And the article was included in Biomacromolecules in 2011.Quality Control of 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate This article mentions the following:

Combining controlled radical polymerizations and a controlled polypeptide synthetic technique, such as N-carboxyanhydride (NCA) ring-opening polymerization, enables the generation of well-defined block copolymers to be easily accessible. Here we combine NCA polymerization with the nitroxide-mediated radical polymerization of poly(Bu acrylate) (PBA) and polystyrene (PS), using a TIPNO and SG1-based bifunctional initiator to create a hybrid block copolymer. The polypeptide block consists of (block) copolymers of poly(L-glutamic acid) embedded with various quantities of L-alanine. The formed superstructures (vesicles and micelles) of the block copolymers possessed varying degrees of enzyme responsiveness when exposed to elastase and thermolysin, resulting in controlled enzymic degradation dictated by the polypeptide composition The PBA containing block copolymers possessing 50% L-alanine in the polypeptide block showed a high degradation response compared to polymers containing lower L-alanine quantities. The particles stabilized by copolypeptides with L-alanine near the hydrophobic block showed full degradation within 4 days. Particles containing polystyrene blocks revealed no appreciable degradation under the same conditions, highlighting the specificity of the system and the importance of synthetic polymer selection. However, when the degradation temperature was increased to 70 °C, degradation could be achieved due to the higher block copolymer exchange between the particle and the solution A number of novel biohybrid structures are disclosed that show promise as enzyme-responsive materials with potential use as payload release vehicles, following their controlled degradation by specific, target, enzymes. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Quality Control of 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Quality Control of 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Establishment of HPLC fingerprint of Sophora tonkinensis var. polyphylla from Guangxi and comparison of concordance with HPLC fingerprint of S. tonkinensis was written by Liu, Ji-cheng;Lu, Sen-hua;Xie, Wei;Lu, Wen-jie. And the article was included in Zhongguo Shiyan Fangjixue Zazhi in 2014.Formula: C22H22O10 This article mentions the following:

Objective: To establish the HLPC fingerprint method of Sophora tonkinensis var. polyphylla, to provide the reference for scientific evaluation and quality control of S. tonkinensis var. polyphylla herb, and to provide the reference data for the homol. study of Sophora tonkinensis var. polyphylla and S. tonkinensis through comparing the fingerprints. Method: An HPLC method was used. An Agilent Eclipse XDB-C₁₈ (4.6 mm × 250 mm, 5 μm) column was adopted, and the mobile phase consisted of acetonitrile and 0.05 mol·L^-1 potassium dihydrogen phosphate solution (adjusted with triethylamine pH 6.4) with a gradient elution. The flow rate was 1.0 mL·min^-1, the column temperature was 30°C, and the detection wavelength was 215 nm. A ‘Chromatog. Fingerprint Evaluation System 2004A Edition’ software was used for data processing. Result: The establishment fingerprint of S. tonkinensis var. polyphylla had 14 common peaks and 7 peaks of them were identified using the reference retention time and UV-DAD detector extracted spectra dual qual. indicators. Most of the compare similarities of fingerprints of each batch herb were above 0.90, in line with the requirements of fingerprint technol. research. Compared with the fingerprint of S. tonkinensis var. polyphylla and S. tonkinensis, the similarity was above 0.90. Conclusion: The precision, stability and reproducibility of the established method were good. The method could be effectively used for the quality control of S. tonkinensis var. polyphylla herb and provide a scientific basis for the development and use of the herb. It could be inferred that S. tonkinensis var. polyphylla and S. tonkinensis had similar ingredients and close relationships from the comparison study of their fingerprints. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Formula: C22H22O10).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Formula: C22H22O10

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enhanced photo-catalytic efficiency through dual-functional ZIF based materials: Fabrication and application as a degradation of organic dyes was written by Li, Xuelian;Raza, Saleem;Liu, Changkun. And the article was included in Journal of the Taiwan Institute of Chemical Engineers in 2021.Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) This article mentions the following:

Photocatalytic technol. is considered the most promising green technol. for the degradation and removal of organic pollutants. In this paper, an innovative multifunctional photocatalytic material has been successfully prepared The zeolitic-imidazolate-framework-67 (ZIF-67) was first synthesized by an easy and green approach. Then, a polydopamine (PDA) mid-layer was incorporated on its surface via dopamine self-polymerization, which not only serves as a stable linking agent, but also increases the amount of visible light captured and reduces the recombination of photogenerated electron-hole pairs. After the hydrolysis and hydrothermal process of tetra-Bu orthotitanate, the TiO₂ nanoparticles were uniformly grafted on the surface, and finally, the hollow ZIF-67@PDA@TiO₂ was successfully obtained. The prepared H-ZIF-67@PDA@TiO₂ photocatalyst was characterized by various techniques, and further used for the photo degradation of a variety of dyes in wastewater in the presence of visible light. A degradation rate of almost 100% was achieved for Acid Fuchsin and Congo Red within 40 min, followed by Erythrosine B and Rose Bengal with a 99% degradation rate within 150 min. Moreover, the ZIF-67-based photocatalyst exhibited high stability and recyclability and maintained an excellent photocatalytic performance during continued cycling. Furthermore, the superoxide radical (•O^–₂) and the hydroxyl radical (•OH) were the primary and secondary reactive species during photodegradation Overall, the excellent performance of this simple photocatalyst was clearly demonstrated, and its numerous advantages, such as low energy consumption, low cost, non-toxicity, and environmental friendliness, showing promising potential for its practical implementation. In the experiment, the researchers used many compounds, for example, Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)).

Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate) (cas: 16423-68-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: Sodium 2′,4′,5′,7′-tetraiodo-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-3′,6′-bis(olate)

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Additive manufactured macroporous chambers facilitate large volume soft tissue regeneration from adipose-derived extracellular matrix was written by Zhang, Guo;Ci, Hai;Ma, Chenggong;Li, Zhipeng;Jiang, Wenbin;Chen, Lifeng;Wang, Zhenxing;Zhou, Muran;Sun, Jiaming. And the article was included in Acta Biomaterialia in 2022.HPLC of Formula: 1461-15-0 This article mentions the following:

Breast tissue engineering is a promising alternative intervention for breast reconstruction. Due to their low immunogenicity and well-preserved adipogenic microenvironment, decellularized adipose tissue (DAT) can potentially regenerate adipose tissue in vivo. However, the volume of adipose tissue regenerated from DAT can hardly satisfy the demand for breast reconstruction. Tissue engineering chamber (TEC) is an effective technique for generation of large adipose tissue volumes However, TEC applications necessitate reoperation to remove non-degradable plastic chambers and harvest autologous tissue flaps, which prolongs the operation time and causes potential damage to donor sites. We improved the TEC strategy by combining bioresorbable polycaprolactone (PCL) chambers and decellularized adipose tissues (DAT). A miniaturized porous PCL chamber was fabricated based on scaling differences between human and rabbit chests, and basic fibroblast growth factor (bFGF)-loaded DAT successfully prepared In rabbit models, a highly vascularized adipose tissue that nearly filled up the PCL chamber (5 mL) was generated de novo from 0.5 mL bFGF-loaded DAT. The newly formed tissue had significantly high expressions of adipogenic genes, compared to the endogenous adipose tissue. The concept described here can be exploited for breast tissue engineering. Decellularized adipose tissue (DAT), which provides infiltrated cells adipogenic microenvironment, can potentially regenerate adipose tissue in vivo. Nevertheless, the volume of regenerated adipose tissue is insufficient to repair large sized tissue defect. Tissue engineering chamber (TEC) could provide a protective space for in situ regeneration of large volume tissue. Herein, a new strategy by combining biodegradable polycaprolactone chambers and basic fibroblast growth factor-loaded decellularized adipose tissue is proposed. In rabbit model, newly formed adipose tissue regenerated from DAT successfully filled the dome shaped chamber with ten folds higher volume than DAT, which is proportionally similar to women breast. This work highlighted the importance of adipogenic microenvironment and protective space for adipose tissue regeneration. In the experiment, the researchers used many compounds, for example, 2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0HPLC of Formula: 1461-15-0).

2,2′,2”,2”’-(((3′,6′-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-2′,7′-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (cas: 1461-15-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.HPLC of Formula: 1461-15-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Metabolomics reveals inosine 5′-monophosphate is increased during mice adipocyte browning was written by Takahashi, Haruya;Tokura, Motohiro;Kawarasaki, Satoko;Nagai, Hiroyuki;Iwase, Mari;Nishitani, Kento;Okaze, Haruka;Mohri, Shinsuke;Ito, Tetsuro;Ara, Takeshi;Jheng, Huei-Fen;Nomura, Wataru;Kawada, Teruo;Inoue, Kazuo;Goto, Tsuyoshi. And the article was included in Journal of Biological Chemistry in 2022.Related Products of 24280-93-1 This article mentions the following:

Adipocyte browning is one of the potential strategies for the prevention of obesity-related metabolic syndromes, but it is a complex process. Although previous studies make it increasingly clear that several transcription factors and enzymes are essential to induce browning, it is unclear what dynamic and metabolic changes occur in induction of browning. Here, we analyzed the effect of a beta-adrenergic receptor agonist (CL316243, accelerator of browning) on metabolic change in mice adipose tissue and plasma using metabolome anal. and speculated that browning is regulated partly by IMP (IMP) metabolism To test this hypothesis, we investigated whether Ucp-1, a functional marker of browning, mRNA expression is influenced by IMP metabolism using immortalized adipocytes. Our study showed that mycophenolic acid, an IMP dehydrogenase inhibitor, increases the mRNA expression of Ucp-1 in immortalized adipocytes. Furthermore, we performed a single administration of mycophenolate mofetil, a prodrug of mycophenolic acid, to mice and demonstrated that mycophenolate mofetil induces adipocyte browning and miniaturization of adipocyte size, leading to adipose tissue weight loss. These findings showed that IMP metabolism has a significant effect on adipocyte browning, suggesting that the regulator of IMP metabolism has the potential to prevent obesity. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Related Products of 24280-93-1).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Related Products of 24280-93-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction was written by Shino, Michael Y.;Todd, Jamie L.;Neely, Megan L.;Kirchner, Jerry;Frankel, Courtney W.;Snyder, Laurie D.;Pavlisko, Elizabeth N.;Fishbein, Gregory A.;Schaenman, Joanna M.;Mason, Kristen;Kesler, Karen;Martinu, Tereza;Singer, Lianne G.;Tsuang, Wayne;Budev, Marie;Shah, Pali D.;Reynolds, John M.;Williams, Nikki;Robien, Mark A.;Palmer, Scott M.;Weigt, S. Sam;Belperio, John A.. And the article was included in American Journal of Transplantation in 2022.Formula: C17H20O6 This article mentions the following:

Histopathol. lung allograft injuries are putative harbingers for chronic lung allograft dysfunction (CLAD). However, the mechanisms responsible are not well understood. CXCL9 and CXCL10 are potent chemoattractants of mononuclear cells and potential propagators of allograft injury. We hypothesized that these chemokines would be quantifiable in plasma, and would associate with subsequent CLAD development. In this prospective multicenter study, we evaluated 721 plasma samples for CXCL9/CXCL10 levels from 184 participants at the time of transbronchial biopsies during their first-year post-transplantation. We determined the association between plasma chemokines, histopathol. injury, and CLAD risk using Cox proportional hazards models. We also evaluated CXCL9/CXCL10 levels in bronchoalveolar lavage (BAL) fluid and compared plasma to BAL with respect to CLAD risk. Plasma CXCL9/CXCL10 levels were elevated during the injury patterns associated with CLAD, acute rejection, and acute lung injury, with a dose-response relationship between chemokine levels and CLAD risk. Importantly, there were strong interactions between injury and plasma CXCL9/CXCL10, where histopathol. injury associated with CLAD only in the presence of elevated plasma chemokines. We observed similar associations and interactions with BAL CXCL9/CXCL10 levels. Elevated plasma CXCL9/CXCL10 during allograft injury may contribute to CLAD pathogenesis and has potential as a minimally invasive immune monitoring biomarker. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Formula: C17H20O6).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Formula: C17H20O6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem