Analyzing the synthesis route of 10242-10-1

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

10242-10-1, 5-Chlorobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Synthesis Example 69 (0667) (5-Chloro-benzofuran-2-yl)methanol (0668) To a tetrahydrofuran solution (12 mL) of 5-chlorobenzofuran-2-carboxylic acid (620 mg, 3.15 mmol), borane-tetrahydrofuran complex (7.88 mL, 7.88 mmol, tetrahydrofuran solution) was added at 0 C. and the resultant solution was stirred at room temperature for 3 hours, at 60 C. for 1 day, and at room temperature for 1 day. After completion of the reaction, concentration under reduced pressure was carried out three times with adding methanol to the reaction solution and the concentrated solution was purified by silica gel column chromatography (hexane/ethyl acetate=3/1?1/1 (v/v)) to obtain the title compound (268 mg, yield 47%).

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; Saito, Noriko; Egi, Jun; Nagai, Hiroshi; Ueno, Megumi; Shintani, Yusuke; Inaba, Yusuke; Adachi, Michiaki; Hirai, Yuichi; Kawazu, Takeshi; Yasutake, Koichi; Takahashi, Daiki; (220 pag.)US9403798; (2016); B2;,
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Some tips on 77095-51-3

As the paragraph descriping shows that 77095-51-3 is playing an increasingly important role.

77095-51-3, Benzofuran-6-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

77095-51-3, Benzofuran-6-carboxylic acid (VI) (50 gms , 0.3086 moles) was suspended in 250 ml MDC and cooled to l5-20C. 5 ml DMF was added at l5-20C followed by thionyl Chloride ( 34 ml , 0.4629 moles). The temperature was raised to 35-40C and the reaction mixture was further stirred for 2 hours. The solvent was removed under vacuum at 45C. The residue was stirred in 250 ml MDC and the solution was cooled to 5-l0C. The solution of 5,7-dichloro-l,2,3,4-tetrahydroisoquinoline- 6-carboxylic acid HC1 (V) ( 74.12 gms , 0.2623 moles) and tri ethyl amine ( 215 ml , 1.5432 moles) in 500 ml MDC , was cooled to 5-l0C. To this solution was added benzofuran-6-carboxylic chloride (VII) maintaining temperature at 5-l0C. The temperature was raised to 25-30C and the reaction mixture was further stirred for 2 hours. The reaction mixture was quenched in 500 ml of water. The organic layer was separated, washed with water and stirred with 2.5 gms of charcoal for 30 minutes. The reaction mixture was filtered over hyflo and the clear filtrate evaporated under vacuum at 40-45C. The residue was stirred in 250 ml ethyl acetate and stirred for an hour at 25-30C. The solid was isolated by filtration and dried to yield titled compound. Yield: 95-98%

As the paragraph descriping shows that 77095-51-3 is playing an increasingly important role.

Reference£º
Patent; CIPLA LIMITED; PHULL, Manjinder Singh; RAO, Dharmaraj Ramachandra; MALHOTRA, Geena; THOPPIL, Sanoj Jose; PAWAR, Sunil Akaram; (28 pag.)WO2019/97547; (2019); A1;,
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Downstream synthetic route of 16859-59-9

16859-59-9, 16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various.

16859-59-9, 3-Hydroxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Carboxybenzaldehyde (16, 10.00 g, 66.61 mmol) and ferric chloride (0.030 g, 0.185 mmol) were diluted with thionyl chloride (25 mL) and the mixture was heated at reflux for 1 h. The reaction mixture was allowed to cool to room temperature and concentrated to provide a brown oil. The oil was diluted with hexanes (20 mL) and concentrated to provide a brown solid. The solid was extracted with boiling hexanes (5 x 50 mL), and concentration of the extract provided a white solid (10.96 g, 98percent): mp 52-56 0C (Sloan, et al., 1983; mp 57-59 0C). 1H NMR (300 MHz, CDCl3) delta 7.95-7.93 (m, 1 H), 7.82 (t, J= 7.4 Hz, 1 H), 7.68-7.60 (m, 2 H), 7.10 (s, 1 H).

16859-59-9, 16859-59-9 3-Hydroxyisobenzofuran-1(3H)-one 3804259, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; PURDUE RESEARCH FOUNDATION; THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTENT OF HEALTH & HUMAN SERVICES; WO2009/140467; (2009); A1;,
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Some tips on 209256-42-8

209256-42-8, 209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209256-42-8,2,3-Dihydrobenzofuran-4-carbaldehyde,as a common compound, the synthetic route is as follows.

To a solution of the aldehyde A (1.0 g, 6.75 mmol) in dichloromethane (40 mL) was added triphenylphosphoranylidene-2-propanone (3.2 g, 10.12 mmol). The reaction was refluxed for 16 hrs and the solvent was removed in vacuo. The title compound (white solid, 1.86 g, 99% yield) was purified via silica gel chromatography using 5% ethyl acetate in hexanes as the eluent.

209256-42-8, 209256-42-8 2,3-Dihydrobenzofuran-4-carbaldehyde 18787449, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Bristol-Myers Squibb Company; US6887870; (2005); B1;,
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Brief introduction of 115010-11-2

115010-11-2, The synthetic route of 115010-11-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115010-11-2,2,3-Dihydro-1-benzofuran-5-sulfonoylchloride,as a common compound, the synthetic route is as follows.

INTERMEDIATE 55 7-Iodo-2, 3-dihydro-benzofuran-5-sulfonyl chloride A solution of ICl (7.7 g, 47 mmol) in DCM (100 mL) was added dropwise to a solution of 2,3-dihydro-benzofuran-5-sulfonyl chloride (5 g, 23 mmol; Intermediate 54) in DCM (100 mL) at reflux temperature under nitrogen atmosphere. The reaction was heated at reflux overnight. The reaction mixture was cooled at room temperature and acetonitrile (50 mL) was added. The resultant mixture was washed with a saturated solution of NaHC03 and the organic phase was separated followed by elimination of the volatiles under vacuum to give 8 g of brown oil which was used to the next step without further purification. 1H NMR 270 MHz (CDC13) 8 ppm 3.45 (t,. J=8. 91 Hz, 2 H) 4.82 (t, J=8. 91 Hz, 2 H) 7.79 (d, J=1. 48 Hz, 1 H) 8.16 (d, J=1. 98 Hz, 1 H).

115010-11-2, The synthetic route of 115010-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOVITRUM AB; WO2005/58858; (2005); A1;,
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Downstream synthetic route of 4265-16-1

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.,4265-16-1

6-Aminocoumarin (1.0 mmol) and benzofuran-2-carbaldehyde (1.2 mmol) were refluxed in absolute ethanol (15 mL) for 4 hours, then naturally cooled to room temperature, and then hydrobored under ice bath. Sodium (2.5 mmol), after reacting for 3 hours, concentrated under reduced pressure to remove ethanol, extracted with dichloromethane, washed with water, and then evaporated. 1) A pale yellow solid (258 mg, yield: about 88.5%) was obtained as a benzofuran-substituted coumarin amine derivative of the formula I.

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Yangzhou Industry Polytechnic College; Yang Luyu; Chen Huajin; (6 pag.)CN110105345; (2019); A;,
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Downstream synthetic route of 4265-16-1

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Preparative electrolysis experiments were performed using 263 APotentiostat/Galvanostat (Princeton Applied Research, USA). 0.1 MNaClO4-CH3CN solution (10 mL) containing aldehydes (1 mmol),TEMPO (0.1 mmol), HMDS (2.5mmol) and AcOH (2.5mmol) was electrolyzedwith stirring in an undivided cell (30 mL) equipped with twoplatinum sheets as anode (1.5 cm2) and cathode (3.0 cm2) respectivelyat a constant potential of 1.5 V vs Ag/Ag+ (0.1MAgNO3 in acetonitrile).The electrode separation was 1 cm. When the reaction was finished,10mL of saturatedNa2SO3 solution was added into the reactionmixtureand stirred for 15 min. Then the mixture was extracted with CH2Cl2(20 mL ¡Á 3). The organic layer was dried with anhydrous Na2SO4 andconcentrated in a rotary evaporator. The productswere obtained via purificationof column chromatography and their structures were confirmedby 1H NMR, 13C NMR and MS. NMR was performed on a BrukerAvance III spectrometer. GC-MS was performed on the Thermo TraceISQ instrument with TG 5MS capillary column., 4265-16-1

4265-16-1 Benzo[b]furan-2-carboxaldehyde 61341, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Chen, Qiguo; Fang, Chaojie; Shen, Zhenlu; Li, Meichao; Electrochemistry Communications; vol. 64; (2016); p. 51 – 55;,
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New learning discoveries about 123654-26-2

As the paragraph descriping shows that 123654-26-2 is playing an increasingly important role.

123654-26-2, 4-Amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

a) Triethylamine (0.16 mol) was added to a solution of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic acid (0.16 mol) in chloroform (600 ml) at a temperature below 10 C. Ethyl chloroformate (15.3 ml) was added afterwards and the reaction mixture was stirred for 45 minutes, while cooling on an ice-bath. Gaseous ammonia was allowed to bubble through the mixture and the reaction mixture was stirred for 3 hours at RT. The precipitate was filtered off and consecutively washed with water, 5% NaOH solution, and again water, and dried, yielding 23.5 g (69%) of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxamide (intermediate 7)., 123654-26-2

As the paragraph descriping shows that 123654-26-2 is playing an increasingly important role.

Reference£º
Patent; Janssen Pharmaceutica N.V.; US5854261; (1998); A;,
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Some tips on 41717-32-2

The synthetic route of 41717-32-2 has been constantly updated, and we look forward to future research findings.

41717-32-2,41717-32-2, 1-Benzofuran-2-carbonitrile is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

d) preparation of methyl benzofuran-2-carboximidate hydrochloride 2-Cyanobenzofuran (10.7 g) was dissolved in ethereal HCl (150 ml, 5M) and methanol (12 ml). The resulting mixture was kept at 4 C. for 48 hours. The resulting solid was filtered, washed with ether and dried (13.4 g, 85%). 1 H-NMR (DMSO-d6): 4.30 (s,3H), 7.50 (t,1H), 7.70 (t,1H), 7.80 (d,1H), 7.90 (d,1H), 8.40 (s,1H).

The synthetic route of 41717-32-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Societe de Conseils de Recherches et d’Applications Scientifiques (S.C.R.A.S); US5310930; (1994); A;,
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Downstream synthetic route of 42933-43-7

42933-43-7, 42933-43-7 2,3-Dihydrobenzofuran-5-amine 3841102, abenzofuran compound, is more and more widely used in various.

42933-43-7, 2,3-Dihydrobenzofuran-5-amine is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2,3-dihydro-1 -benzofuran-5-amine (33.7 mg, 0.237 mmol) and DIPEA (0.21 mL, 1 .18 mmol) in DCM (1 mL) was cooled to 0¡ãC before crude 2-chloro-benzothiazole-5-carbonyl chloride (92 mg, 0.237 mmol) dissolved in DCM (1 mL) was added. The mixture was stirred at rt for 30 min. The mixture was diluted with DCM (5 mL) and washed with water (5 mL). the organic extract was dried over Na2S04, filtered and concentrated to give the crude title compound (69 mg) as a pale yellow resin; LC-MS: tR= 0.86 min; [M+H]+= 330.97;1H NMR (400 MHz, D6-DMSO): delta 10.28 (s, 1 H), 8.56 (d, J = 1 .1 Hz, 1 H), 8.26 (d, J = 8.5 Hz, 1 H), 8.07 (dd, J, = 1 .5 Hz, J2= 8.5 Hz, 1 H), 7.70 (s, 1 H), 7.45 (dd, J, = 1 .7 Hz, J2= 8.5 Hz, 1 H), 6.76 (d, J = 8.5 Hz, 1 H), 4.54 (t, J = 8.7 Hz, 2 H), 3.21 (t, J = 8.7 Hz, 2 H).

42933-43-7, 42933-43-7 2,3-Dihydrobenzofuran-5-amine 3841102, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOLLI, Martin; BOSS, Christoph; RICHARD-BILDSTEIN, Sylvia; SIEBER, Patrick; (95 pag.)WO2016/207785; (2016); A1;,
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