Heterocyclic Building Block-benzofuran

Synthetic Route of 39581-55-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.39581-55-0, Name is 5-Methoxybenzofuran-3(2H)-one, molecular formula is C9H8O3. In a Patent，once mentioned of 39581-55-0

This invention concerns the compounds (I); the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein X is NR2, O, S, SO, SO2; R1 is hydrogen, cyano, halo, substituted carbonyl, methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; n is 1, 2 or 3; R2 is hydrogen, aryl substituted with a radical -COOR4; or R2 is substituted C1-10alkyl, C2-10alkenyl or C3-7cycloalkyl; or R2 is a radical of formula: (b-1); (b-2); -CpH2p-CH(OR14)-CqH2q-R15 (b-3); -CH2-CH2-(O-CH2-CH2)m-OR14 (b-4); -CH2-CH2-(O-CH2-CH2)m-NR5aR5b (b-5); -a1=a2-a3=a4- is -CH=CH-CH=CH- ; -N=CH-CH=CH- ;-CH=N-CH=CH- ; -CH=CH- N=CH- ; -CH=CH-CH=N- (c-5); wherein one of the hydrogen atoms in (c-1) – (c-5) is replaced by particular radicals; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxycarbonyl, substituted carbonyl, methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy- methanimidamidyl or Het1.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 39581-55-0

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2220O – PubChem

Reference of 4687-25-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4687-25-6, Name is Benzofuran-3-carbaldehyde, molecular formula is C9H6O2. In a Patent，once mentioned of 4687-25-6

The present invention provides compounds of Formula (I) as inhibitors of LMP7 for the treatment of autoimmune and inflammatory diseases. In formula (I), Rb and Rc are independently selected from one another from H or C1-C6-alkyl; whereby Rb and Rc may be linked to form a 5 or 6 membered-ring containing the oxygen atoms to which they are linked; Q denotes Ar, Het or cycloalkyl; R1 R2 independently from each other denotes H, ORa, Hal, C1-C6-alkyl wherein 1 to 5 H atoms may be independently replaced by OH or Hal; Y denotes CR 3R4, preferably CH2 or C(CH3)2; R3, R4 independently of one another denote H or C1-C6-alkyl; L denotes L1 or L2 or alkyl; n is an integer selected from 0 to 3; L 1 is Q1-CO-M- wherein Q1 is Ar or Het, preferably, phenyl, naphthyl or pyridine, optionally substituted with 1 to 5 groups independently selected from ORa, Hal, phenyl, and C1-C6-alkyl wherein 1 to 5H atoms may be independently replaced by OH or Hal; L2 is Q2-M- wherein Q2 is a fused bicyclic system containing 1 nitrogen atom and 1 to 3 additional groups independently selected from O, S, N, or CO, and wherein at least one of the rings is aromatic whereby the fused bicyclic system is optionally substituted with 1 to 5 groups independently selected from ORa, Hal, phenyl, and C1-C6-alkyl wherein 1 to 5 H atoms may be independently replaced by OH or Hal; or Q 2 is unsaturated or aromatic 5 membered-ring system containing 1 to 3 heteroatoms selected from N, O, S and CO, and optionally substituted with a phenyl ring or pyridine ring whereby phenyl ring and pyridine ring are optionally substituted with 1 to 4 groups independently selected from ORa, Hal, phenyl, and C1-C6-alkyl wherein 1 to 5 H atoms may be independently replaced by OH or Hal; M is a linear or branched alkylene having 1 to 5 carbon atoms wherein 1 or 2 H atoms may be replaced by OR a or a phenyl ring optionally substituted with 1 to 5 groups independently selected from Hal, ORa, and C1-C6-alkyl optionally substituted with 1 to 5 groups independently selected from OH, and Hal; or M denotes a cycloalkylene having 3 to 7 carbon atoms; or M denotes a thiazolidinyl group; R a is H or C1-C6-alkyl wherein 1 to 5 H atom may be independently replaced by OH or Hal; Ar denotes a 6 membered-aromatic carbocyclic ring optionally fused with another carbocyclic saturated, unsaturated or aromatic ring having 5 to 8 carbon atoms; Het denotes a 5- or 6-membered saturated, unsaturated or aromatic heterocyclic ring having 1 to 3 heteroatoms independently selected from N, N+O-, O, S, SO, and SO 2, and optionally fused with another saturated, unsaturated or aromatic ring having 5 to 8 atoms and optionally containing 1 to 3 hetero atoms selected from N, O, and S; Hal denotes Cl, Br, I of F; preferably Cl or F

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1157O – PubChem

Application of 4265-25-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.4265-25-2, Name is 2-Methylbenzofuran, molecular formula is C9H8O. In a article，once mentioned of 4265-25-2

Sixteen Orthic Chernozemic surface soil samples, one half from virgin prairie and one half from adjacent cultivated prairie (cultivated for 31 to 94 years), were collected from eight sites throughout Southern Saskatchewan, Canada. Samples were analyzed for total organic C and a number of other chemical and physical properties. The virgin and cultivated soils at site No. 4 were selected for more detailed analysis by CP-MAS 13C NMR, Curie-point-pyrolysis-gas chromatography/mass spectrometry (Cp-Py-GC/MS), and by pyrolysis-field ionization mass spectrometry (Py-FIMS). Long-term cultivation resulted in large significant decreases in total SOM (soil organic matter), as represented by total soil organic C. There were significant increases in aromaticity of the SOM as a result of long-term cultivation as indicated by CP-MAS 13C NMR spectroscopy. This was mainly attributable to the result of cultivation-enhanced degradation of aliphatic C relative to aromatic C. Organic compounds identified in the Cp-Py-GC/MS spectra of the virgin and cultivated soils at site No. 4 consisted of n-alkanes (ranging from C 11 to C22) and alkenes (ranging from C7:1 to C21:1), with the virgin soil being richer in alkenes than the cultivated soil. Other components identified were cyclic aromatics, carbocyclics, N-containing aromatics, N-heterocyclics, benzene and substituted benzenes, phenols and substituted phenols and substituted furans. The compounds identified appeared to originate from long-chain aliphatics, lignins, polyphenols, aromatics, polysaccharides, and N-containing compounds in the two soils. While qualitatively similar compounds were identified by Py-FIMS in the two soils, the total ion intensity (TII) of the virgin soil was almost 2.5 times as high as that of the cultivated soil. This suggests that cultivation made the organic matter less volatile, either by favouring the formation of higher molecular weight organic matter or by promoting the formation of non-volatile metal-organic matter complexes. The Py-FIMS spectra showed that the virgin soil contained relatively more lignin dimers, lipids, sterols, and n-C16 to n-C34 fatty acids than the cultivated soil. Thus, conversely, the cultivated soil was richer in carbohydrates, phenols and lignin monomers, alkyl aromatics and N-containing compounds, including peptides, than the virgin soil.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4265-25-2

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H267O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: Benzofuran-2-carboxylic acid, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 496-41-3, name is Benzofuran-2-carboxylic acid. In an article，Which mentioned a new discovery about 496-41-3

To find novel non-hydroxamate histone deacetylase (HDAC) inhibitors, a series of compounds modeled after suberoylanilide hydroxamic acid (SAHA) was designed and synthesized. In this series, compound 7, in which the hydroxamic acid of SAHA is replaced by a thiol, was found to be as potent as SAHA, and optimization of this series led to the identification of HDAC inhibitors more potent than SAHA. In cancer cell growth inhibition assay, S-isobutyryl derivative 51 showed strong activity, and its potency was comparable to that of SAHA. The cancer cell growth inhibitory activity was verified to be the result of histone hyperacetylation and subsequent induction of p21WAF1/CIP1 by Western blot analysis. Kinetical enzyme assay and molecular modeling suggest the thiol formed by enzymatic hydrolysis within the cell interacts with the zinc ion in the active site of HDACs.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1982O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 496-41-3. Introducing a new discovery about 496-41-3, Name is Benzofuran-2-carboxylic acid

Several phosphonic diethyl esters were synthesized and their calcium antagonistic activity evaluated in vitro.The diethyl phosphonate group was condensed on substituted , <(2-benzofuranyl)phenylmethyl>, <(4-(diphenylmehyl-1-piperazinyl) methyl>, <4-(4-diphenylmethyl-1-piperazinyl methyl) phenylmethyl>, and <4-(3-phenyl-2-propenyl)-1-piperazinyl methyl> groups.Despite the presence of the diethyl phosphonate moiety and the benzhydrylpiperazinyl group, both present in potent calcium antagonist structures, only 1 of the 19 synthesis compounds exhibited a calcium antagonistic profile. diethyl phosphonate / benzhydryl piperazine / calcium antagonist

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 496-41-3, you can also check out more blogs about496-41-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2039O – PubChem

125-20-2, Name is Thymolphthalein, belongs to benzofurans compound, is a common compound. category: benzofuranIn an article, once mentioned the new application about 125-20-2.

The aim of this study was to evaluate the indicators of osteogenesis, cytotoxicity and genotoxicity of an experimental beta tri-calcium phosphate (experimental beta-TCP) compared with two other bone substitutes: bovine hydroxyapatite (HA) (Bio-Oss Geistlich) and beta tri-calcium phosphate (beta-TCP Bionnovation). The cell viability and genotoxicity were measured by MTT and MNT assay, respectively. The indicators of osteogenesis were analyzed by alkaline phosphatase activity, total protein content, and calcium deposition. The MTT and MNT assay showed that none of the tested materials was cytotoxic nor genotoxic. Concerning the indicators of osteogenesis, it was observed that cells in contact with all the materials were able to induce the osteogenesis and this process was influenced by the period of the cell culture in contact with bone substitutes. Based on the results of this study, it was concluded that this experimental beta-TCP appears to be a promising material as a bone substitute.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H4353O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4265-16-1, name is Benzo[b]furan-2-carboxaldehyde, introducing its new discovery. Safety of Benzo[b]furan-2-carboxaldehyde

We report herein an efficient gold(I)-catalyzed post-Ugi domino dearomatization/ipso-cyclization/Michael sequence that enables access to libraries of diverse (hetero)arene-annulated tricyclic heterocycles. This process affords novel complex polycyclic scaffolds in moderate to good yields from readily available acyclic precursors with excellent chemo-, regio-, and diastereoselectivity. The power of this strategy has been demonstrated by the rapid synthesis of 40 highly functionalized polyheterocycles bearing indole, pyrrole, (benzo)furan, (benzo)thiophene, pyrazole, and electron-rich arene groups in two operational steps.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H845O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1563-38-8

In this work the TiO2 solar-photocatalytical degradation of the pesticide carbofuran (CBF) in water, at lab and pilot scale, was studied. At lab scale the evaluation of CBF concentration (14-282mumolL-1) showed that the system followed a Langmuir-Hinshelwood kinetics type. TiO2 concentration (0.05-2gL-1) and initial pH (3-9) were also evaluated and optimized using the surface response methodology and the Pareto diagram. In the range of variables studied, initial pH 7.60 and 1.43gL-1 of TiO2 favoured the efficiency of the process. Under optimal conditions the evolution of substrate, chemical oxygen demand, dissolved organic carbon, toxicity and organics by-products were evaluated. In the pilot scale tests, using direct sunlight, 55mgL-1 of CBF in a commercial formulation was eliminated after 420min; while after 900min of treatment 80% of toxicity (1/E50 on Vibrium Fischeri), 80% of chemical oxygen demand and 60% of dissolved organic carbon were removed. The analysis and evolution of five CBF by-products, as well the evaluation of the treatment in the presence of isopropanol or using acetonitrile as a solvent suggest that the degradation is mainly carried out by OH radical attack. Finally, a schema depicting the main degradation pathway is proposed.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2388O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 496-41-3, name is Benzofuran-2-carboxylic acid, introducing its new discovery. Safety of Benzofuran-2-carboxylic acid

We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 496-41-3, and how the biochemistry of the body works.Safety of Benzofuran-2-carboxylic acid

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1937O – PubChem

Application of 4265-16-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2. In a Article，once mentioned of 4265-16-1

The trans,trans isomers of 2-[2-(4-methylphenyl)ethenyl]-3-(2-phenylethenyl)benzo[b]furan and four derivatives have been synthesized by a sequence of reactions according to known methods. These new conjugated compounds have been characterized spectrally and photophysically. They practically do not react but decay by radiative relaxation. The high fluorescence quantum yields of these photostable compounds make them interesting as good fluorescent probes. The triplet behaviour of the NO2-derivative has been investigated by laser flash photolysis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 4265-16-1. In my other articles, you can also check out more blogs about 4265-16-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H720O – PubChem