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Chemistry is traditionally divided into organic and inorganic chemistry. category: benzofuran, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 39581-55-0

Novel 4-hydroxy-3-phenyl-2H-pyrano[3,2-b]benzofuran-2-ones (15a-d), were synthesized in a one-step procedure by the reaction of substituted benzofuran-3-ones 12a-d and (chlorocarbonyl)phenyl ketene. Copyright Taylor & Francis Group, LLC.

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Benzofuran – Wikipedia,
Benzofuran | C8H2231O – PubChem

Related Products of 39581-55-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 39581-55-0, molcular formula is C9H8O3, introducing its new discovery.

3-Piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed. Methods of using the derivatives and compositions containing the derivatives in the prevention and/or treatment of serotonin disorders, such as depression and anxiety, are also disclosed. Additionally, processes for the preparation of 3-piperidin-4-yl-1H-indole and 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole derivatives are disclosed.

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Benzofuran – Wikipedia,
Benzofuran | C8H2217O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C9H8O3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 39581-55-0

The leukotrienes, metabolites of arachidonic acid produced through the action of the enzyme 5-lipoxygenase, are important mediators of immediate hypersensitivity and inflammation.Among the variety of diseases in which the leukotrienes may play a symptomatic or causative role is the dermatological condition psoriasis, a chronic proliferative disease of the skin.This study reports the synthesis and comparative biological activities of various ortho-substituted phenols including 4-methoxyphenols, 6-hydroxy-1,2,3,4-tetrahydrobenzopyrans, 2,3-dihydro-5-benzofuranols, and 5-benzofuranols.The phenols prepared in this study were evaluated for their ability to inhibit the production of leukotriene B4(LTB4) in isolated human polymorphonuclear leukocytes (PMNs) and to inhibit a topical inflammatory response in the topical mouse ear (TME) model.In the former case, when the log IC50 was plotted versus the log of the octanol/water partition coefficient (log P), to eliminate the effect of lipophilicity, the 2,3-dihydro-5-benzofuranol ring system was shown to be more potent than the other ring systems examined throughout the range of partition coefficients studied.The ability to inhibit leukotriene production in vitro in human PMNs can be rationalized on the basis of a model that suggests that the observed inhibition is dependent on the kinetic ability of the inhibitor to reduce a radical species and on the fraction of inhibitor that is partitioned into the cell membrane.While the in vivo antiinflammatory activity as measured by the TME did not correlate with the in vitro data, it was felt that the TME represented a valuable measure of the ability of a compound to penetrate the skin to the site of an ongoing inflammatory response.Of the compounds synthesized in this study, 6-<1-<2-(hydroxymethyl)phenyl>-1-propen-3-yl>-2,3-dihydro-5-benzofuranol (1, L-651896) was chosen for further development.

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Benzofuran – Wikipedia,
Benzofuran | C8H2233O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 39581-55-0, name is 5-Methoxybenzofuran-3(2H)-one, introducing its new discovery. Recommanded Product: 39581-55-0

A new method for the synthesis of benzofuran-3(2H)-ones under microwave conditions was developed. The reaction conditions were screened, and the scope of benzoate substrates was investigated. The results showed that our method could provide rapid access to these important dihydrobenzofuranones in 43% to 58% yields.

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Benzofuran – Wikipedia,
Benzofuran | C8H2234O – PubChem

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3-Oxo-2,3-dihydrobenzo[b]furans, -thiophenes and -selenophenes 1a-c afforded the bromo-aldehydes 2 under Vilsmeier-Haack-Arnold conditions. Palladium-catalysed aryl-aryl coupling of 2 with o-formyl-phenylboronic acid allowed the formation of dialdehydes 3 which underwent McMurry cyclisation or pinacol condensation to yield polycyclic aromatic derivatives 4 or the dihydroxylated compounds 5.

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Benzofuran – Wikipedia,
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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. name: 5-Methoxybenzofuran-3(2H)-one, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 39581-55-0, name is 5-Methoxybenzofuran-3(2H)-one. In an article，Which mentioned a new discovery about 39581-55-0

A series of substituted racemic naphthofurans were synthesized as ‘hybrid’ molecules of the two major prototypical hallucinogenic drug classes, the phenethylamines and the tryptamines/ergolines. Although it was hypothesized that these new agents might possess high affinity for the serotonin 5-HT(2A)/(2C) receptor subtypes, unexpected affinity for muscarinic receptors was observed. The compounds initially synthesized for this study were (±)-anti- and syn-4-amino-6-methoxy-2a,3,4,5-tetrahydro-2H-naphtho[1,8- bc]furan (4a,b), respectively, and their 8-bromo derivatives 4c,d, respectively. The brominated primary mines 4c,d were assayed initially for activity in the two-lever drug discrimination (DD) paradigm in rats trained to discriminate saline from LSD tartrate (0.08 mg/kg). Also, 4c,d were evaluated for their ability to compete against agonist and antagonist radioligands at cloned human 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors. After the syn diastereomers were found to have the highest activity in these preliminary assays, the N-alkylated analogues syn-N,N-dimethyl-4-amino-6- methoxy-2a,3,4,5-tetrahydro-2H-naphtho[1,8-bc]furan (4e) and syn-N,N- dipropyl-4-amino-6-methoxy-2a,3,4,5-tetrahydro-2H-naphtho[1,8-bc]furan (4f) were prepared and assayed for their affinities at [3H]ketanserin-labeled 5- HT(2A) and [3H]-8-OH-DPAT-labeled 5-HT(1A) sites. All of the molecules tested had relatively low affinity for serotonin receptors, yet a preliminary screen indicated that compound 4d had affinity for muscarinic receptors. Thus, 4b,d,e were evaluated for their affinity at muscarinic M1-M5 receptors and also assessed for their functional characteristics at the M1 and M2 isoforms. Compound 4d had affinities of 12-33 nM at all of the muscarinic sites, with 4b,e having much lower affinity. All three compounds fully antagonized the effects of carbachol at the M1 receptor, while only 4d completely antagonized carbachol at the M2 receptor. The fact that the naphthofurans lack LSD-like activity suggests that they do not bind to the serotonin receptor in a way such that the tricyclic naphthofuran nucleus is bioisosteric with, and directly superimposable upon, the A, B, and C rings of LSD. This also implies, therefore, that the hallucinogenic phenethylamines cannot be directly superimposed on LSD in a common binding orientation for these two chemical classes, contrary to previous hypotheses.

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Benzofuran – Wikipedia,
Benzofuran | C8H2240O – PubChem

Reference of 39581-55-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 39581-55-0, molcular formula is C9H8O3, introducing its new discovery.

A new series of (Z)-2-(1-methyl-5-nitroimidazole-2-ylmethylene)-3(2 H)-benzofuranones (11a-p) and (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2 H)-benzofuranones (12a-m) were synthesized and assayed for their antibacterial activity against Gram-positive and Gram-negative bacteria. Most of the 5-nitroimidazole analogues (11a-p) showed a remarkable inhibition of a wide spectrum of Gram-positive bacteria (Staphylococcus aureus, Streptococcus epidermidis, MRSA, and Bacillus subtilis) and Gram-negative Klebsiella pneumoniae, whereas 4-nitroimidazole analogues (12a-m) were not effective against selected bacteria. The quantitative structure-activity relationship investigations were applied to find out the correlation between the experimentally evaluated activities with various parameters of the compounds studied. The QSAR models built in this work had reasonable predictive power and could be explained by the observed trends in activities.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2232O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 5-Methoxybenzofuran-3(2H)-one, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 39581-55-0, name is 5-Methoxybenzofuran-3(2H)-one. In an article，Which mentioned a new discovery about 39581-55-0

Two 99mTc/Re complexes based on flavone and aurone were tested as potential probes for imaging beta-amyloid plaques using single photon emission computed tomography. Both 99mTc-labeled derivatives showed higher affinity for Abeta(1-42) aggregates than did 99mTc-BAT. In sections of brain tissue from an animal model of AD, the Re-flavone derivative 9 and Re-aurone derivative 19 intensely stained beta-amyloid plaques. In biodistribution experiments using normal mice, 99mTc-labeled flavone and aurone displayed similar radioactivity pharmacokinetics. With additional modifications to improve their brain uptake, 99mTc complexes based on the flavone or aurone scaffold may serve as probes for imaging cerebral beta-amyloid plaques.

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Benzofuran – Wikipedia,
Benzofuran | C8H2242O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 39581-55-0, name is 5-Methoxybenzofuran-3(2H)-one, introducing its new discovery. HPLC of Formula: C9H8O3

In this study, the Aldol condensation between benzofuran-3(2H)-ones and ketones or aldehydes mediated by alumina was developed. This simple protocol facilitated the synthesis of various 2-(2-hydroxypropan-2-yl)benzofuran-3(2H)-ones in moderate-to-high yields under mild conditions.

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Benzofuran – Wikipedia,
Benzofuran | C8H2230O – PubChem

Application of 39581-55-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 39581-55-0, Name is 5-Methoxybenzofuran-3(2H)-one, molecular formula is C9H8O3. In a Article，once mentioned of 39581-55-0

Three sets of antibacterial nitrofuran derivatives [set I, 5-R-substituted (Z)-2-(5-nitrofuran-2-ylmethylene)-3(2H)-benzofuranones (R = OCH3, H, CH3, C2H5, nC3H7, Cl, Br, CN, and NO2) and their 2-hydroxyphenyl and 2-acetoxyphenyl analogues; set TT, 5-R-substituted (E)-1-(2-hydroxyphenyl)-3-(5-nitrofuryl)-2-propen-1-ones (R = H, CH3, C2H5, Cl, and NO2); and set III, 5-R-substituted (E)-l-(2-acetoxyphenyl)-3-(5-nitrofuryl)-2-propen-l-ones (R = H, CH3; C2H5, Cl, and NO2)] were prepared and tested against a Gram-positive (Staphylococcus aureus, strain ATCC-25923) and a Gram-negative bacterium (Caulobacter crescentus, strain NA 1000). QSAR equations derived for the IC50 values against both bacteria show negative contributions of two terms: An electronic one, expressed either by sigma, the Hammett substituent constant, or by E, the cyclic voltametric reduction potential. Another term described by an indicator variable, Iabs, is assigned the value of 0 for set I compounds and the value of 1 for sets II and III. No important contribution of the hydrophobic factor was found. For the three sets, the QSAR regressions suggest that the same structural features describe the activities for both bacteria and that, although reduction is a necessary step, it should not be the determining one. These results agree with those found for the QSAR of 5-nitroimidazole analogues.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2243O – PubChem